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01-05-2020 | Review

What we can learn from the complex architecture of single axons

Author: Kathleen S. Rockland

Published in: Brain Structure and Function | Issue 4/2020

Abstract

Anterogradely labeled connections at the single-axon level provide unparalleled spatial and quantitative data as well as a novel perspective on laminar, columnar, hierarchical and other aspects of cortical organization. Here, I briefly summarize single-axon results from representative examples of thalamocortical, corticocortical, callosal, and lateral intrinsic connections, with attention to implications for cortical organization. Particularly worth emphasizing is the intricate spatial configuration and striking morphometric heterogeneity of individual axons even within the same system of connections. A short section touches on patterns of axonal trajectories in the distal, preterminal few millimeters. Emphasis is on studies in nonhuman primates from about 1983 to present, with non-viral tracers and 2-D reconstruction (i.e., compressed z-axis) in the early visual cortical pathway. The last section recapitulates what this approach can tell us about inter-areal communication and cortical organization, and possible implications for dynamics and effective connectivity, and concludes with comments on open questions and future directions.

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Title: What we can learn from the complex architecture of single axons
Author: Kathleen S. Rockland
Publication date: 01-05-2020
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 4/2020
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-019-02023-3

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What we can learn from the complex architecture of single axons

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