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01-01-2016 | Original Article

Local corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb

Authors: Isabella Garcia, Paramjit K. Bhullar, Burak Tepe, Joshua Ortiz-Guzman, Longwen Huang, Alexander M. Herman, Lesley Chaboub, Benjamin Deneen, Nicholas J. Justice, Benjamin R. Arenkiel

Published in: Brain Structure and Function | Issue 1/2016

Abstract

Neuropeptides play important physiological functions during distinct behaviors such as arousal, learning, memory, and reproduction. However, the role of local, extrahypothalamic neuropeptide signaling in shaping synapse formation and neuronal plasticity in the brain is not well understood. Here, we characterize the spatiotemporal expression profile of the neuropeptide corticotropin-releasing hormone (CRH) and its receptor CRHR1 in the mouse OB throughout development. We found that CRH-expressing interneurons are present in the external plexiform layer, that its cognate receptor is expressed by granule cells, and show that both CRH and CRHR1 expression enriches in the postnatal period when olfaction becomes important towards olfactory-related behaviors. Further, we provide electrophysiological evidence that CRHR1-expressing granule cells functionally respond to CRH ligand, and that the physiological circuitry of CRHR1 knockout mice is abnormal, leading to impaired olfactory behaviors. Together, these data suggest a physiologically relevant role for local CRH signaling towards shaping the neuronal circuitry within the mouse OB.

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Title: Local corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb
Authors: Isabella Garcia
Paramjit K. Bhullar
Burak Tepe
Joshua Ortiz-Guzman
Longwen Huang
Alexander M. Herman
Lesley Chaboub
Benjamin Deneen
Nicholas J. Justice
Benjamin R. Arenkiel
Publication date: 01-01-2016
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 1/2016
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-014-0888-4

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Local corticotropin releasing hormone (CRH) signals to its receptor CRHR1 during postnatal development of the mouse olfactory bulb

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