Top

Published in:

01-01-2013 | Original Article

Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem

Authors: Ewing Duque, Arturo Mangas, Pablo Salinas, Zaida Díaz-Cabiale, José Angel Narváez, Rafael Coveñas

Published in: Brain Structure and Function | Issue 1/2013

Abstract

We have studied the distribution of alpha-neo-endorphin- or neurokinin B-immunoreactive fibres and cell bodies in the adult human brainstem with no prior history of neurological or psychiatric disease. A low density of alpha-neo-endorphin-immunoreactive cell bodies was only observed in the medullary central gray matter and in the spinal trigeminal nucleus (gelatinosa part). Alpha-neo-endorphin-immunoreactive fibres were moderately distributed throughout the human brainstem. A high density of alpha-neo-endorphin-immunoreactive fibres was found only in the solitary nucleus (caudal part), in the spinal trigeminal nucleus (caudal part), and in the gelatinosa part of the latter nucleus. Neurokinin B-immunoreactive cell bodies (low density) were found in the periventricular central gray matter, the reticular formation of the pons and in the superior colliculus. The distribution of the neurokinin-immunoreactive fibres was restricted. In general, for both neuropeptides the density of the immunoreactive fibres was low. In the human brainstem, the proenkephalin system was more widely distributed than the prodynorphin system, and the preprotachykinin A system (neurokinin A) was more widely distributed than the preprotachykinin B system (neurokinin B).

Bouras C, Taban CH, Constantinidis J (1984) Mapping of enkephalins in the human brain. Neuroscience 12:179–190PubMedCrossRef

Chigr F, Najimi M, Leduque P, Charnay Y, Jordan D, Chayvialle JA, Tohyama M, Kopp N (1989) Anatomical distribution of somatostatin immunoreactivity in the infant brainstem. Neuroscience 29:615–628PubMedCrossRef

Cone RI, Weber E, Barchas JD, Goldstein A (1983) Regional distribution of dynorphin and neo-endorphin peptides in rat brain, spinal cord, and pituitary. J Neurosci 3:2146–2152PubMed

Coveñas R, de León M, Narváez JA, Aguirre JA, Tramu G, González-Barón S (1999) Anatomical distribution of beta-endorphin (1–27) in the cat brainstem: an immunocytochemical study. Anat Embryol 199:161–167PubMedCrossRef

Coveñas R, Martín F, Belda M, Smith V, Salinas P, Rivada E, Díaz-Cabiale Z, Narváez JA, Marcos P, Tramu G, González-Barón S (2003) Mapping of neurokinin-like immunoreactivity in the human brainstem. BMC Neurosci 4:3PubMedCrossRef

Coveñas R, Martín F, Salinas P, Rivada E, Smith V, Aguilar LA, Díaz-Cabiale Z, Narváez JA, Tramu G (2004) An immunocytochemical mapping of methionine-enkephalin-Arg⁶-Gly⁷-Leu⁸ in the human brainstem. Neuroscience 128:843–859PubMedCrossRef

Coveñas R, Mangas A, Narváez JA (2007) Introduction to neuropeptides. In: Coveñas R, Mangas A, Narváez JA (eds) Focus on neuropeptide research. Transworld Research Network, Trivandrum, pp 1–26

Coveñas R, Duque E, Mangas A, Marcos P, Narváez JA (2008) Neuropeptides in the monkey (Macaca fascicularis) brainstem. In: Mangas A, Coveñas R, Geffard M (eds) Brain molecules: from vitamins to molecules for axonal guidance, Transworld Research Network, Trivandrum, pp 131–156

Cuadrado I, Coveñas R, Aguilar LA, Aguirre JA, Rioja J, Narváez JA (2005) Mapping of neurokinin B in the cat brainstem. Anat Embryol 210:133–143PubMedCrossRef

del Fiacco M, Dessi ML, Levanti MC (1984) Topographical localization of substance P in the human post-mortem brainstem. An immunohistochemical study in the newborn and adult tissue. Neuroscience 12:591–611PubMedCrossRef

Guntern R, Vallet PG, Bouras C, Constantinidis J (1989) An improved immunohistostaining procedure for peptides in human brain. Experientia 45:159–161PubMedCrossRef

Haines DE (1987) Neuroanatomy: an atlas of structures, sections and systems. Urban and Schwarzenberg, Baltimore

Lucas LR, Hurley DL, Krause JE, Harlan RE (1992) Localization of the tachykinin neurokinin B precursor peptide in rat brain by immunocytochemistry and in situ hybridization. Neuroscience 51:317–345PubMedCrossRef

Mai JK, Stephens PH, Hopf A, Cuello AC (1986) Substance P in the human brain. Neuroscience 17:709–739PubMedCrossRef

Mai JK, Triepel J, Metz J (1987) Neurotensin in the human brain. Neuroscience 22:499–524PubMedCrossRef

Mangas A, Coveñas R, Bodet D, Duleu S, Marcos P, Geffard M (2009) Vitamins in the monkey brain: an immunocytochemical study. J Chem Neuroanat 38:1–8PubMedCrossRef

Marcos P, Coveñas R, Narváez JA, Tramu G, Aguirre JA, González- Barón S (1993) Alpha-neo-endorphin-like immunoreactivity in the cat brain stem. Peptides 14:1263–1269PubMedCrossRef

Marksteiner J, Sperk G, Krause JE (1992) Distribution of neurons expressing neurokinin B in the rat brain: immunocytochemistry and in situ hybridization. J Comp Neurol 317:341–356PubMedCrossRef

Maysinger D, Höllt V, Seizinger BR, Mehraein P, Pasi A, Herz A (1982) Parallel distribution of immunoreactive alpha-neo-endorphin and dynorphin in rat and human tissue. Neuropeptides 2:211–225CrossRef

Mazzone SB, Geraghty DP (2000) Respiratory actions of tachykinins in the nucleus of the solitary tract: characterization of receptors using selective agonists and antagonists. Br J Pharmacol 129:1121–1131PubMedCrossRef

Merchenthaler I, Maderdrut JL, O’Harte F, Conlon JM (1992) Localization of neurokinin B in the central nervous system of the rat. Peptide 13:815–829

Mileusnic D, Lee JM, Magnuson DJ, Hejna MJ, Krause JE, Lorens JB, Lorens SA (1999a) Neurokinin-3 receptor distribution in rat and human brain: an immunohistochemical study. Neuroscience 89:1269–1290PubMedCrossRef

Mileusnic D, Magnuson DJ, Hejna MJ, Lorens JB, Lorens SA, Lee JM (1999b) Age and species-dependent differences in the neurokinin B system in rat and human brain. Neurobiol Aging 20:19–35PubMedCrossRef

Nomura H, Shiosaka S, Tohyama M (1987) Distribution of substance P-like immunoreactive structures in the brainstem of the adult human brain: an immunocytochemical study. Brain Res 24:365–370CrossRef

Palkovits M (1988) Neuropeptides in the brain. In: Martini L, Ganong WF (eds) Frontiers in neuroendocrinology, vol 10. Raven Press, New York, pp 1–44

Palkovits M, Browstein MJ, Zamir N (1983) Immunoreactive dynorphyn and alpha-neo-endorphin in rat hypothalamo-neurohypophyseal system. Brain Res 278:258–261PubMedCrossRef

Pesini P, Pego-Reigosa R, Tramu G, Coveñas R (2001) Distribution of alpha- neo-endorphin immunoreactivity in the diencephalon and the brainstem of the dog. J Chem Neuroanat 22:251–262PubMedCrossRef

Picard P, Regoli D, Couture R (1994) Cardiovascular and behavioural effect of centrally administered tachykinins in the rat: characterization of receptors with selective antagonists. Br J Pharmacol 112:240–249PubMedCrossRef

Rance NE, Krajewski SJ, Smith MA, Cholanian M, Dacks PA (2010) Neurokinin B and the hypothalamic regulation of reproduction. Brain Res 1364:116–128PubMedCrossRef

Rikard-Bell GC, Törk I, Sullivan C, Scheibner T (1990) Distribution of substance P-like immunoreactive fibres and terminals in the medulla oblongata of the human infant. Neuroscience 34:133–148PubMedCrossRef

Sánchez L, Coveñas R, Aguirre JA, Narváez JA, Gómez A, Tramu G (2005) Mapping of tachykinins in the cat spinal cord. Arch Ital Biol 143:29–50PubMed

Schwarzer C (2009) 30 years of dynorphins—new insights on their functions in neuropsychiatric diseases. Pharmacol Ther 123:353–370PubMedCrossRef

Smialowska M, Lason W, Bal A, Przewlocki R (1985) Distribution of immunoreactive α-neo-endorphin in the rat brain. Neurosci Lett 62:359–364PubMedCrossRef

Tateishi K, Matsuoka Y, Hamaoka T (1989) Establishment of highly specific radioimmunoassays for neurokinin A and neurokinin B and determination of tissue distribution of these peptides in rat central nervous system. Regul Peptides 24:245–257CrossRef

Topaloglu AK, Semple RK (2011) Neurokinin B signalling in the human reproductive axis. Mol Cell Endocrinol 346:57–64PubMedCrossRef

Warden MK, Young WS III (1988) Distribution of cells containing mRNAs encoding substance P and neurokinin B in the rat central nervous system. J Comp Neurol 272:90–113PubMedCrossRef

Weber E, Roth KA, Barchas JD (1982) Immunohistochemical distribution of alpha-neo-endorphin/dynorphin neuronal systems in rat brain. Evidence for colocalization. Proc Natl Acad Sci USA 79:3062–3066PubMedCrossRef

Wittmann W, Schunk E, Rosskothen I, Gaburro S, Singewald N, Herzog H, Schwarzer C (2009) Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone. Neuropsychopharmacology 34:775–785PubMedCrossRef

Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (1991) Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain. Brain Res Bull 26:99–111PubMedCrossRef

Title: Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem
Authors: Ewing Duque
Arturo Mangas
Pablo Salinas
Zaida Díaz-Cabiale
José Angel Narváez
Rafael Coveñas
Publication date: 01-01-2013
Publisher: Springer-Verlag
Published in: Brain Structure and Function / Issue 1/2013
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-012-0388-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2013

Cytoarchitectonic mapping of the human dorsal extrastriate cortex

Myelination deficits in schizophrenia: evidence from diffusion tensor imaging

The effects of maternal diabetes on expression of insulin-like growth factor-1 and insulin receptors in male developing rat hippocampus

Structure–function relationship of working memory activity with hippocampal and prefrontal cortex volumes

Common and distinct neural inputs to the medial central nucleus of the amygdala and anterior ventrolateral bed nucleus of stria terminalis in rats

Pyramidal neurons in the superficial layers of rat retrosplenial cortex exhibit a late-spiking firing property