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01-06-2011 | Review

Morphological changes in nerve cells during normal aging

Author: Ennio Pannese

Published in: Brain Structure and Function | Issue 2/2011

Abstract

During normal aging, widespread loss of nerve cells does not occur. Neuronal loss is limited to restricted regions of the nervous system and is slight (probably no more than 10%). The commonest age-related structural changes undergone by nerve cells are as follows: dendrites decrease in number and length and many dendritic spines are lost; axons decrease in number and their myelin sheaths may become less compact and undergo segmental demyelination followed by remyelination; and significant loss of synapses occurs. These changes probably make a significant contribution to the behavioral impairment and cognitive decline that often accompany normal aging.

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Title: Morphological changes in nerve cells during normal aging
Author: Ennio Pannese
Publication date: 01-06-2011
Publisher: Springer-Verlag
Published in: Brain Structure and Function / Issue 2/2011
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-011-0308-y

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Morphological changes in nerve cells during normal aging

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