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Virchows Archiv

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Open Access 01-02-2010 | Review and Perspective

Running GAGs: myxoid matrix in tumor pathology revisited

What’s in it for the pathologist?

Authors: Stefan M. Willems, Malgorzata Wiweger, J. Frans Graadt van Roggen, Pancras C. W. Hogendoorn

Published in: Virchows Archiv | Issue 2/2010

Abstract

Ever since Virchow introduced the entity myxoma, abundant myxoid extracellular matrix (ECM) has been recognized in various reactive and neoplastic lesions. Nowadays, the term “myxoid” is commonly used in daily pathological practice. But what do today’s pathologists mean by it, and what does the myxoid ECM tell the pathologist? What is known about the exact composition and function of the myxoid ECM 150 years after Virchow? Here, we give an overview of the composition and constituents of the myxoid ECM as known so far and demonstrate the heterogeneity of the myxoid ECM among different tumors. We discuss the possible role of the predominant constituents of the myxoid ECM and attempt to relate them to differences in clinical behavior. Finally, we will speculate on the potential relevance of this knowledge in daily pathological practice.

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Title: Running GAGs: myxoid matrix in tumor pathology revisited
What’s in it for the pathologist?
Authors: Stefan M. Willems
Malgorzata Wiweger
J. Frans Graadt van Roggen
Pancras C. W. Hogendoorn
Publication date: 01-02-2010
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 2/2010
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-009-0822-y

Keynote webinar | Spotlight on medication adherence

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Running GAGs: myxoid matrix in tumor pathology revisited

What’s in it for the pathologist?

Abstract

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Abstract

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