Published in:
01-07-2007 | Case Report
Hodgkin’s lymphoma in a patient with Jo-1 syndrome
Authors:
Alexander C. Adam, Christian Grohé, Sebastian Stier, Stefan Gattenlöhner, Zeynep Balta, Reinhard Büttner, Ines Gütgemann
Published in:
Virchows Archiv
|
Issue 1/2007
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Abstract
Jo-1 syndrome is an autoimmune disease with autoantibodies against the histidyl tRNA synthetase. Characteristic clinical findings include inflammatory myopathy and interstitial lung disease. We present the first case of a patient with Jo-1 syndrome (positive Jo-1 autoantibodies, myositis, interstitial alveolitis) who developed Hodgkin’s lymphoma of nodular-sclerosing type. Thus, patients with Jo-1 syndrome and immunosuppressive therapy similar to other patients with autoimmune disease are at risk to develop lymphomas and should therefore be monitored carefully.