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01-05-2005 | Review Article

NF-kB in development and progression of human cancer

Authors: Xavier Dolcet, David Llobet, Judit Pallares, Xavier Matias-Guiu

Published in: Virchows Archiv | Issue 5/2005

Abstract

The nuclear factor kB (NF-kB) comprises a family of transcription factors involved in the regulation of a wide variety of biological responses. NF-kB plays a well-known function in the regulation of immune responses and inflammation, but growing evidences support a major role in oncogenesis. NF-kB regulates the expression of genes involved in many processes that play a key role in the development and progression of cancer such as proliferation, migration and apoptosis. Aberrant or constitutive NF-kB activation has been detected in many human malignancies. In recent years, numerous studies have focused on elucidating the functional consequences of NF-kB activation as well as its signaling mechanisms. NF-kB has turned out to be an interesting therapeutic target for treatment of cancer.

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Title: NF-kB in development and progression of human cancer
Authors: Xavier Dolcet
David Llobet
Judit Pallares
Xavier Matias-Guiu
Publication date: 01-05-2005
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 5/2005
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-005-1264-9

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NF-kB in development and progression of human cancer

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