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01-04-2006 | Original Article

Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas

Authors: Phyu Phyu Aung, Yoshitsugu Mitani, Yuichi Sanada, Hirofumi Nakayama, Keisuke Matsusaki, Wataru Yasui

Published in: Virchows Archiv | Issue 4/2006

Abstract

Claudins are involved in the formation of tight junctions in epithelial and endothelial cells. Claudins form a family of 24 members displaying organ- and tissue-specific patterns of expression. In the present study, we evaluated the specificity of the claudin-2 expression in various normal human tissues and gastrointestinal cancers by quantitative reverse transcriptase–polymerase chain reaction and immunohistochemistry. In 14 various normal tissues, claudin-2 mRNA was expressed in the kidney, liver, pancreas, stomach, and small intestine; the highest level of which was detected in the kidney. Colorectal cancers (CRCs) expressed claudin-2 mRNA at high levels. Immunohistochemical analysis of claudin-2 in 146 gastric cancers (GCs) and 99 CRCs demonstrated claudin-2 expression in 2.1% of GCs and 25.3% of CRCs, respectively. There was no obvious correlation between claudin-2 expression and clinicopathological parameters of CRCs. These results suggest that the expression of claudin-2 may involve organ specificity, and increased expression of claudin-2 may participate in colorectal carcinogenesis.

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Title: Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas
Authors: Phyu Phyu Aung
Yoshitsugu Mitani
Yuichi Sanada
Hirofumi Nakayama
Keisuke Matsusaki
Wataru Yasui
Publication date: 01-04-2006
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 4/2006
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-005-0120-2

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Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas

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