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01-10-2003 | Original Article

CD34⁺ fibrocytes in tubular carcinomas and radial scars of the breast

Authors: Annette Ramaswamy, Roland Moll, Peter J. Barth

Published in: Virchows Archiv | Issue 4/2003

Abstract

The present study was undertaken to analyze whether and to what extent CD34⁺ fibrocytes and α-smooth muscle actin (α-SMA)-positive myofibroblasts occur in the stroma of radial scars and tubular carcinoma of the breast. We investigated a total of 24 radial scars obtained from 23 females and a total of 43 tubular carcinomas. All tubular carcinomas showed a virtually complete loss of CD34⁺ fibrocytes paralleled by a gain of α-SMA-positive myofibroblasts. The peripheral parts of radial scars harbored CD34⁺ fibrocytes comparable to normal breast tissue. In 23 of 24 radial scars, the central core was characterized by a loss of CD34⁺ fibrocytes accompanied by the presence of α-SMA-positive myofibroblasts in six cases, a pattern that up to now has only been described in malignant breast lesions. This finding underlines the close relationship between tubular carcinomas and radial scars. We conclude CD34- and α-SMA immunohistochemistry to be valuable adjunctive tools in distinguishing radial scars from tubular carcinomas. In the present study, the presence of CD34⁺ fibrocytes excluded malignancy. The absence of CD34⁺ fibrocytes paralleled by the presence of α-SMA myofibroblasts indicated malignancy in most cases, although it has to be carefully considered that in a minority of cases (6 of 24) the central core of radial scars may disclose this stromal composition.

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Title: CD34+ fibrocytes in tubular carcinomas and radial scars of the breast
Authors: Annette Ramaswamy
Roland Moll
Peter J. Barth
Publication date: 01-10-2003
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 4/2003
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-003-0855-6

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CD34⁺ fibrocytes in tubular carcinomas and radial scars of the breast

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