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Langenbeck's Archives of Surgery
Published in: Langenbeck's Archives of Surgery 6/2022

20-05-2022 | Ascites | Original Article

Risk factors of chylous ascites and its relationship with long-term prognosis in laparoscopic D3 lymphadenectomy for right colon cancer

Authors: Wei Qin, Dechang Diao, Kai Ye, Ximo Xu, Duohuo Shu, Hao Zhong, Yanyan Hu, Xiao Yang, Batuer Aikemu, Leqi Zhou, Sen Zhang, Pei Xue, Zhenghao Cai, Minhua Zheng, Jianwen Li, Quan Wang, Yueming Sun, Bo Feng

Published in: Langenbeck's Archives of Surgery | Issue 6/2022

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Abstract

Background

Chylous ascites (CA) after laparoscopic D3 lymphadenectomy for right colon cancer is not rare. However, the risk factors for CA have not been fully explored. Few studies have investigated the effect of CA on long-term prognosis.

Methods

The clinical data of patients with right colon cancer who underwent laparoscopic D3 lymphadenectomy in five centers from January 2013 to December 2018 were retrospectively collected. Univariate and multivariate analyses were performed to determine the clinicopathological factors associated with CA. Then, the long-term prognosis of patients with and without CA was compared by propensity score matching and Kaplan–Meier survival analysis.

Results

The incidence of CA was 4.4% (48/1090). Pathological T stage (p = 0.025), dissection along the left side of the superior mesenteric artery (p < 0.001) and the number of retrieved lymph nodes (p < 0.001) were independent risk factors for CA. After propensity score matching, 48 patients in the CA group and 353 patients in the non-CA group were enrolled. Kaplan–Meier survival analysis indicated that CA was not associated with overall survival (p = 0.454) and disease-free survival (p = 0.163). In patients with stage III right colon cancer, there were no significant differences in overall survival (p = 0.501) and disease-free survival (p = 0.254).

Conclusions

Pathological T stage, number of retrieved lymph nodes, and left side dissection along the superior mesenteric artery were independent risk factors for CA after laparoscopic D3 lymphadenectomy. CA does not impair the oncological outcomes of patients.
Appendix
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Metadata
Title
Risk factors of chylous ascites and its relationship with long-term prognosis in laparoscopic D3 lymphadenectomy for right colon cancer
Authors
Wei Qin
Dechang Diao
Kai Ye
Ximo Xu
Duohuo Shu
Hao Zhong
Yanyan Hu
Xiao Yang
Batuer Aikemu
Leqi Zhou
Sen Zhang
Pei Xue
Zhenghao Cai
Minhua Zheng
Jianwen Li
Quan Wang
Yueming Sun
Bo Feng
Publication date
20-05-2022
Publisher
Springer Berlin Heidelberg
Published in
Langenbeck's Archives of Surgery / Issue 6/2022
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-022-02527-3

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