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Langenbeck's Archives of Surgery

Published in:

01-10-2013 | Original Article

Local tissue ischemia is not necessary for suture-induced adhesion formation

Authors: Taufiek Konrad Rajab, Christoph Brochhausen, Markus Wallwiener

Published in: Langenbeck's Archives of Surgery | Issue 7/2013

Abstract

Background

We investigated the hypothesis that local tissue ischemia is responsible for suture-induced adhesion formation.

Methods

A total of 160 interrupted sutures were placed in the parietal peritoneum of 20 Wistar rats. The animals were randomized into an ischemia group, where the sutures were pulled tight and a non-ischemia group, where the sutures were tied as loose loops with air knots to avoid any local ischemia. The midline laparotomy was closed with a running suture. On postoperative day 10, adhesions to the sutures were counted.

Results

There was no statistically significant difference in the number of adhesions forming to sutures with local ischemia (n = 66/80) versus sutures without local ischemia (n = 69/80).

Conclusion

We conclude that local tissue ischemia is not necessary for suture-induced adhesion formation and propose an additional mechanical mechanism to explain how suture knots can predispose to adhesiogenesis.

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Title: Local tissue ischemia is not necessary for suture-induced adhesion formation
Authors: Taufiek Konrad Rajab
Christoph Brochhausen
Markus Wallwiener
Publication date: 01-10-2013
Publisher: Springer Berlin Heidelberg
Published in: Langenbeck's Archives of Surgery / Issue 7/2013
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-013-1084-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Local tissue ischemia is not necessary for suture-induced adhesion formation

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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