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01-06-2012 | Rapid Communication

Evaluation of selected cognitive functions before and after surgery for primary hyperparathyroidism

Authors: Dominika Babińska, Marcin Barczyński, Tomasz Stefaniak, Tomasz Osęka, Anna Babińska, Dariusz Babiński, Krzysztof Sworczak, Andrzej J. Łachiński, Wojciech Nowak, Zbigniew Śledziński

Published in: Langenbeck's Archives of Surgery | Issue 5/2012

Abstract

Background and aims

Cognitive functions have been reported to be impaired in patient with primary hyperparathyroidism (pHPT). The aim of this psychological study was to evaluate cognitive disturbances in pHPT in relation to serum calcium levels before and after surgery.

Patients and methods

A prospective, case–control study with 1-year follow-up of 35 pHPT patients versus 35 matched controls was undertaken. All patients were tested before surgery and at 12–18 months following surgery with a battery of selected cognitive function psychological tools: Benton Visual Retention Test (BVRT), Wisconsin Card Sorting Test (WCST), Memory Verbal Learning Test (DCS), The Rey's Auditory Verbal Learning Test (RAVLT), Trail Making Test A & B, Verbal Fluency Test, and Beck Depression Inventory. In addition to psychological testing, serum calcium, parathyroid hormone and phosphate levels were evaluated.

Results

The following cognitive functions of pHPT patients versus controls were deteriorated before surgery: impaired concentration, decreased nonverbal learning process, difficulties in using direct memory, verbal fluency and visual constructive abilities. However, no correlation was found between serum calcium levels and the results of neuropsychological tests. In longitudinal comparison of pHPT patients before and 1 year after surgery, there was a significant improvement in visual memory, visual–constructive abilities and direct memory.

Conclusions

pHPT patients have significantly decreased concentration level, nonverbal learning process, access to verbal resources and constructional and visual memory ability. Thus, neuropsychological testing may be useful in the decision making for early surgery in patients with mild asymptomatic disease in order to avoid further deterioration of cognitive functions.

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Title: Evaluation of selected cognitive functions before and after surgery for primary hyperparathyroidism
Authors: Dominika Babińska
Marcin Barczyński
Tomasz Stefaniak
Tomasz Osęka
Anna Babińska
Dariusz Babiński
Krzysztof Sworczak
Andrzej J. Łachiński
Wojciech Nowak
Zbigniew Śledziński
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 5/2012
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-011-0885-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Evaluation of selected cognitive functions before and after surgery for primary hyperparathyroidism

Abstract

Background and aims

Patients and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background and aims

Patients and methods

Results

Conclusions

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