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Langenbeck's Archives of Surgery

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01-12-2011 | Original Article

Impact of CT-based diagnostic imaging on management and outcome of nonfunctioning pancreatic tumors

Authors: Katja Maschuw, Volker Fendrich, Peter Langer, C. Volland, Annette Ramaswamy, Detlef K. Bartsch

Published in: Langenbeck's Archives of Surgery | Issue 8/2011

Abstract

Background

Sporadic malignant non-functioning pancreatic endocrine tumors (NF-PETs) are an important subset of pancreatic neoplasms. The aim of this study was to assess the impact of improved imaging on these features in a tertiary referral centre within a 20-year follow-up.

Patients and methods

From 1988 to 2009, 51 patients were treated for sporadic malignant NF-PETs. Forty-one patients who underwent tumor resection were retrospectively attributed according to the date of the initial diagnosis, group 1: 1988–1999 vs. group 2: 2000–2009.

Results

Cross-sectional imaging led to positive prediction of NF-PETs in all patients. Curative resection was achieved in 76%. Synchronous metastases were present in 56% with a positive prediction of 43%. In group 1, the mean reported CT-determined tumor size was 56 vs. 54 mm in group 2 (p = 0.89). Synchronous metastases were present in 61% in group 1 vs. 57% (p = 0.99) in group 2. Metachronous metastases were recorded in 39% in group 1 vs. 43% (p = 0.84) in group 2. The mean interval from initial resection to diagnosis of metastatic disease was significantly shorter (p = 0.01) in patients from group 1 (14 vs. 61 months). Cumulative 5- and 10-year survival rates were 77% and 72% in group 1 vs. a 5-year survival rate of 66% in group 2.

Conclusion

So far, improved CT-based imaging has no impact on earlier detection of initial synchronous metastases in sporadic malignant NF-PETs, while metachronous metastases are detected earlier.

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Title: Impact of CT-based diagnostic imaging on management and outcome of nonfunctioning pancreatic tumors
Authors: Katja Maschuw
Volker Fendrich
Peter Langer
C. Volland
Annette Ramaswamy
Detlef K. Bartsch
Publication date: 01-12-2011
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 8/2011
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-011-0748-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impact of CT-based diagnostic imaging on management and outcome of nonfunctioning pancreatic tumors

Abstract

Background

Patients and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Patients and methods

Results

Conclusion

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