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01-01-2009 | Original Article

Prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer: impact of patterns of pelvic recurrence on curative resection

Authors: Jea-Kun Park, Young-Wan Kim, Hyuk Hur, Nam-Kyu Kim, Byung-Soh Min, Seung-Kook Sohn, Young-Deuk Choi, Young-Tae Kim, Jung-Bai Ahn, Jae-Kyung Roh, Ki-Chang Keum, Jin-Sil Seong

Published in: Langenbeck's Archives of Surgery | Issue 1/2009

Abstract

Background

The purpose of this study is to investigate prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer and determine whether recurrence patterns influence curative resection of recurrent tumor.

Materials and methods

We examined 62 patients with isolated local recurrence following total mesorectal excision (TME) of the primary rectal cancer. Recurrence patterns were classified as central, anterior, posterior, lateral, and perineal with respect to the intra-pelvic tumor location. Prognostic factors affecting oncologic outcomes were analyzed, and the rate of curative resection was analyzed according to recurrence patterns.

Results

The mean follow-up period was 49.0 ± 29.0 months, and the mean time to recurrence after TME was 27.9 ± 23.3 months. Twenty-three patients underwent curative resection, and the remaining 39 patients received palliative treatment. Patients with a central recurrence had the highest rate of curative resection (p = 0.006). The overall 5-year survival rate was 13.9% and significantly higher in those treated with curative resection (35.1%; p = 0.0002). Multivariate analysis demonstrated that disease-free survival less than 1 year and curative resection of local recurrence were independent prognostic factors influencing 5-year survival.

Conclusion

Patients with central recurrences have a high probability of curative resection. Disease-free survival less than 1 year and curative resection of local recurrence were independent prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer.

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Title: Prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer: impact of patterns of pelvic recurrence on curative resection
Authors: Jea-Kun Park
Young-Wan Kim
Hyuk Hur
Nam-Kyu Kim
Byung-Soh Min
Seung-Kook Sohn
Young-Deuk Choi
Young-Tae Kim
Jung-Bai Ahn
Jae-Kyung Roh
Ki-Chang Keum
Jin-Sil Seong
Publication date: 01-01-2009
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 1/2009
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-008-0391-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer: impact of patterns of pelvic recurrence on curative resection

Abstract

Background

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Materials and methods

Results

Conclusion

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