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Published in: Langenbeck's Archives of Surgery 4/2008

01-07-2008 | Case Management and Clinical Consequences

Solitary fibrous tumour of the liver with IGF-II-related hypoglycaemia. A case report

Authors: F. Famà, Yves Le Bouc, G. Barrande, A. Villeneuve, M. G. Berry, R. R. Pidoto, O. Saint Marc

Published in: Langenbeck's Archives of Surgery | Issue 4/2008

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Abstract

Introduction

We report a rare case of solitary fibrous tumour (SFT) of the liver associated with non-islet cell tumour hypoglycaemia (NICTH), which caused a hypoglycaemic coma due to over-production of big-insulin-like growth factor-II.

Discussion

Although generally benign, SFTs are better characterised, lately due to Western blot, but less than 40 cases have been reported where the liver is the target organ. In only two benign cases has hypoglycaemia been a feature.

Conclusion

We report for the first time a demonstrable relationship between benign liver SFT and NICTH.
Literature
1.
go back to reference Klemperer P, Rabin CB (1931) Primary neoplasms of the pleura. A report of five cases. Arch Pathol 11:385–412 Klemperer P, Rabin CB (1931) Primary neoplasms of the pleura. A report of five cases. Arch Pathol 11:385–412
2.
go back to reference Fletcher CDM (2006) The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology 48:3–12PubMedCrossRef Fletcher CDM (2006) The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology 48:3–12PubMedCrossRef
3.
go back to reference Strom EH, Skjorten F, Aarseth LB, Haug E (1991) Solitary fibrous tumor of the pleura. An immunohistochemical, electron microscopic and tissue culture study of a tumor producing insulinlike growth factor I in a patient with hypoglycemia. Pathol Res Pract 187:109–113 discussion 114–116PubMed Strom EH, Skjorten F, Aarseth LB, Haug E (1991) Solitary fibrous tumor of the pleura. An immunohistochemical, electron microscopic and tissue culture study of a tumor producing insulinlike growth factor I in a patient with hypoglycemia. Pathol Res Pract 187:109–113 discussion 114–116PubMed
4.
go back to reference Khalifa MA, Montgomery EA, Azumi N, Gomes MN, Zeman RK, Min KW, Lack EE (1997) Solitary fibrous tumors: a series of lesions, some in unusual sites. South Med J 90:793–799PubMedCrossRef Khalifa MA, Montgomery EA, Azumi N, Gomes MN, Zeman RK, Min KW, Lack EE (1997) Solitary fibrous tumors: a series of lesions, some in unusual sites. South Med J 90:793–799PubMedCrossRef
5.
go back to reference Vallat-Decouvelaere AV, Dry SM, Fletcher CD (1998) Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol 22:1501–1511PubMedCrossRef Vallat-Decouvelaere AV, Dry SM, Fletcher CD (1998) Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol 22:1501–1511PubMedCrossRef
6.
7.
go back to reference Saint-Marc O, Pozzo A, Causse X, Heitzmann A, Debillon G (2002) Solitary fibrous liver tumor: clinical, radiological and pathological characteristics. Gastroenterol Clin Biol 26:171–173PubMed Saint-Marc O, Pozzo A, Causse X, Heitzmann A, Debillon G (2002) Solitary fibrous liver tumor: clinical, radiological and pathological characteristics. Gastroenterol Clin Biol 26:171–173PubMed
8.
go back to reference Guglielmi A, Frameglia M, Iuzzolino P, Martignoni G, De Manzoni G, Laterza E, Veraldi GF, Girlanda R (1998) Solitary fibrous tumor of the liver with CD 34 positivity and hypoglycemia. J Hepatobiliary Pancreat Surg 5:212–216PubMedCrossRef Guglielmi A, Frameglia M, Iuzzolino P, Martignoni G, De Manzoni G, Laterza E, Veraldi GF, Girlanda R (1998) Solitary fibrous tumor of the liver with CD 34 positivity and hypoglycemia. J Hepatobiliary Pancreat Surg 5:212–216PubMedCrossRef
9.
go back to reference Chithriki M, Jaibaji M, Vandermolen R (2004) Solitary fibrous tumor of the liver with presenting symptoms of hypoglycemic coma. Am Surg 70:291–293PubMed Chithriki M, Jaibaji M, Vandermolen R (2004) Solitary fibrous tumor of the liver with presenting symptoms of hypoglycemic coma. Am Surg 70:291–293PubMed
10.
go back to reference Nevius DB, Friedman NB (1959) Mesotheliomas and extraovarian thecomas with hypoglycemic and nephritic syndromes. Cancer 12:1263–1269PubMedCrossRef Nevius DB, Friedman NB (1959) Mesotheliomas and extraovarian thecomas with hypoglycemic and nephritic syndromes. Cancer 12:1263–1269PubMedCrossRef
11.
go back to reference Apostolopoulos A, Ling WS (1982) Hypoglycemia associated with a large histiocytic lymphoma: case presentation and literature review. Mt Sinai J Med 49:318–322PubMed Apostolopoulos A, Ling WS (1982) Hypoglycemia associated with a large histiocytic lymphoma: case presentation and literature review. Mt Sinai J Med 49:318–322PubMed
12.
go back to reference Bessell EM, Selby C, Ellis IO (1999) Severe hypoglycaemia caused by raised insulin-like growth factor II in disseminated breast cancer. J Clin Pathol 52:780–781PubMedCrossRef Bessell EM, Selby C, Ellis IO (1999) Severe hypoglycaemia caused by raised insulin-like growth factor II in disseminated breast cancer. J Clin Pathol 52:780–781PubMedCrossRef
13.
go back to reference Macaulay VM (1992) Insulin-like growth factors and cancer. Br J Cancer 65:311–320PubMed Macaulay VM (1992) Insulin-like growth factors and cancer. Br J Cancer 65:311–320PubMed
14.
go back to reference Werner H, LeRoith D (1996) The role of the insulin-like growth factor system in human cancer. Adv Cancer Res 68:183–223PubMed Werner H, LeRoith D (1996) The role of the insulin-like growth factor system in human cancer. Adv Cancer Res 68:183–223PubMed
15.
go back to reference Asakawa K, Hizuka N, Takano K, Fukuda I, Sukegawa I, Demura H, Shizume K (1990) Radioimmunoassay for insulin-like growth factor II (IGF-II). Endocrinol Jpn 37:607–614PubMed Asakawa K, Hizuka N, Takano K, Fukuda I, Sukegawa I, Demura H, Shizume K (1990) Radioimmunoassay for insulin-like growth factor II (IGF-II). Endocrinol Jpn 37:607–614PubMed
16.
go back to reference Fehmann HC, Jehle P, Markus U, Goke B (1996) Functional active receptors for insulin-like growth factors-I (IGF-I) and IGF-II on insulin-, glucagon-, and somatostatin-producing cells. Metabolism 45:759–766PubMedCrossRef Fehmann HC, Jehle P, Markus U, Goke B (1996) Functional active receptors for insulin-like growth factors-I (IGF-I) and IGF-II on insulin-, glucagon-, and somatostatin-producing cells. Metabolism 45:759–766PubMedCrossRef
17.
go back to reference Hanau CA, Miettinen M (1995) Solitary fibrous tumor: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol 26:440–449PubMedCrossRef Hanau CA, Miettinen M (1995) Solitary fibrous tumor: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol 26:440–449PubMedCrossRef
18.
go back to reference Moran CA, Ishak KG, Goodman ZD (1998) Solitary fibrous tumor of the liver: a clinicopathologic and immunohistochemical study of nine cases. Ann Diagn Pathol 2:19–24PubMedCrossRef Moran CA, Ishak KG, Goodman ZD (1998) Solitary fibrous tumor of the liver: a clinicopathologic and immunohistochemical study of nine cases. Ann Diagn Pathol 2:19–24PubMedCrossRef
19.
go back to reference Yilmaz S, Kirimlioglu V, Ertas E, Hilmioglu F, Yildirim B, Katz D, Mizrak B (2000) Giant solitary fibrous tumor of the liver with metastasis to the skeletal system successfully treated with trisegmentectomy. Dig Dis Sci 45:168–174PubMedCrossRef Yilmaz S, Kirimlioglu V, Ertas E, Hilmioglu F, Yildirim B, Katz D, Mizrak B (2000) Giant solitary fibrous tumor of the liver with metastasis to the skeletal system successfully treated with trisegmentectomy. Dig Dis Sci 45:168–174PubMedCrossRef
20.
go back to reference Chan G, Horton PJ, Thyssen S, Lamarche M, Nahal A, Hill DJ, Marliss EB, Metrakos P (2007) Malignant transformation of a solitary fibrous tumor of the liver and intractable hypoglycemia. J Hepatobiliary Pancreat Surg 14:595–599PubMedCrossRef Chan G, Horton PJ, Thyssen S, Lamarche M, Nahal A, Hill DJ, Marliss EB, Metrakos P (2007) Malignant transformation of a solitary fibrous tumor of the liver and intractable hypoglycemia. J Hepatobiliary Pancreat Surg 14:595–599PubMedCrossRef
21.
go back to reference Kahn CR (1980) The riddle of tumour hypoglycaemia revisited. Clin Endocrinol Metab 9:335–360PubMed Kahn CR (1980) The riddle of tumour hypoglycaemia revisited. Clin Endocrinol Metab 9:335–360PubMed
22.
go back to reference Sato R, Tsujino M, Nishida K, Otani Y, Minami T, Shichiri M, Hizuka N, Aiba M, Hitara Y (2004) High molecular weight form insulin-like growth factor II-producing mesenteric sarcoma causing hypoglycemia. Intern Med 43:967–971PubMedCrossRef Sato R, Tsujino M, Nishida K, Otani Y, Minami T, Shichiri M, Hizuka N, Aiba M, Hitara Y (2004) High molecular weight form insulin-like growth factor II-producing mesenteric sarcoma causing hypoglycemia. Intern Med 43:967–971PubMedCrossRef
23.
go back to reference Kageyama K, Moriyama T, Hizuka N, Sakihara S, Takayasu S, Tamasawa N, Suda T (2003) Hypoglycemia associated with big insulin-like growth factor II produced during development of malignant fibrous histiocytoma. Endocr J 50:753–758PubMedCrossRef Kageyama K, Moriyama T, Hizuka N, Sakihara S, Takayasu S, Tamasawa N, Suda T (2003) Hypoglycemia associated with big insulin-like growth factor II produced during development of malignant fibrous histiocytoma. Endocr J 50:753–758PubMedCrossRef
24.
go back to reference Daughaday WH, Emanuele MA, Brooks MH, Barbato AL, Kapadia M, Rotwein P (1988) Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia. N Engl J Med 319:1434–1440PubMed Daughaday WH, Emanuele MA, Brooks MH, Barbato AL, Kapadia M, Rotwein P (1988) Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia. N Engl J Med 319:1434–1440PubMed
25.
go back to reference Goya L, de la Puente A, Ramos S, Martin MA, Escriva F, Pascual-Leone AM (1999) Regulation of insulin-like growth factor-I and -II by glucose in primary cultures of fetal rat hepatocytes. J Biol Chem 274:24633–24640PubMedCrossRef Goya L, de la Puente A, Ramos S, Martin MA, Escriva F, Pascual-Leone AM (1999) Regulation of insulin-like growth factor-I and -II by glucose in primary cultures of fetal rat hepatocytes. J Biol Chem 274:24633–24640PubMedCrossRef
26.
go back to reference Nielsen FC, Christiansen J (1995) Posttranscriptional regulation of insulin-like growth factor II mRNA. Scand J Clin Lab Invest Suppl 220:37–46PubMed Nielsen FC, Christiansen J (1995) Posttranscriptional regulation of insulin-like growth factor II mRNA. Scand J Clin Lab Invest Suppl 220:37–46PubMed
27.
go back to reference Scharf JG, Dombrowski F, Ramadori G (2001) The IGF axis and hepatocarcinogenesis. Mol Pathol 54:138–144PubMedCrossRef Scharf JG, Dombrowski F, Ramadori G (2001) The IGF axis and hepatocarcinogenesis. Mol Pathol 54:138–144PubMedCrossRef
28.
go back to reference Daughaday WH, Trivedi B, Kapadia M (1981) Measurement of insulin-like growth factor II by a specific radioreceptor assay in serum of normal individuals, patients with abnormal growth hormone secretion, and patients with tumor-associated hypoglycemia. J Clin Endocrinol Metab 53:289–294PubMed Daughaday WH, Trivedi B, Kapadia M (1981) Measurement of insulin-like growth factor II by a specific radioreceptor assay in serum of normal individuals, patients with abnormal growth hormone secretion, and patients with tumor-associated hypoglycemia. J Clin Endocrinol Metab 53:289–294PubMed
29.
go back to reference Marks V, Teale JD (1991) Tumours producing hypoglycaemia. Diabetes Metab Rev 7:79–91PubMed Marks V, Teale JD (1991) Tumours producing hypoglycaemia. Diabetes Metab Rev 7:79–91PubMed
30.
go back to reference Shapiro ET, Bell GI, Polonsky KS, Rubenstein AH, Kew MC, Tager HS (1990) Tumor hypoglycemia: relationship to high molecular weight insulin-like growth factor-II. J Clin Invest 85:1672–1679PubMedCrossRef Shapiro ET, Bell GI, Polonsky KS, Rubenstein AH, Kew MC, Tager HS (1990) Tumor hypoglycemia: relationship to high molecular weight insulin-like growth factor-II. J Clin Invest 85:1672–1679PubMedCrossRef
Metadata
Title
Solitary fibrous tumour of the liver with IGF-II-related hypoglycaemia. A case report
Authors
F. Famà
Yves Le Bouc
G. Barrande
A. Villeneuve
M. G. Berry
R. R. Pidoto
O. Saint Marc
Publication date
01-07-2008
Publisher
Springer-Verlag
Published in
Langenbeck's Archives of Surgery / Issue 4/2008
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-008-0329-z

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