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European Journal of Applied Physiology

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19-07-2023 | Hyperglycemia | Original Article

Skipping breakfast does not accelerate the hyperglycemia-induced endothelial dysfunction but reduces blood flow of the brachial artery in young men

Authors: Tatsuki Kamoda, Rintaro Sakamoto, Masaki Katayose, Saki Yamamoto, Toru Neki, Kohei Sato, Erika Iwamoto

Published in: European Journal of Applied Physiology | Issue 1/2024

Abstract

Purpose

Postprandial hyperglycemia is assumed to have a negative impact on flow-mediated dilation (FMD), an index of endothelial function, and blood flow of the peripheral conduit arteries. This study aimed to determine whether the enhancement of postprandial hyperglycemia by skipping breakfast accelerates endothelial dysfunction and reduces the blood flow in the brachial artery in young men.

Methods

Using a randomized cross-over design, ten healthy men completed two trials: with and without breakfast (Eating and Fasting trials, respectively). Venous blood sampling and brachial FMD tests were conducted before, 30, 60, 90, and 120 min after a 75-g oral glucose tolerance test (OGTT).

Results

Skipping breakfast boosted post-OGTT glucose levels than having breakfast (P = 0.01). The magnitude of the decrease in FMD via OGTT did not vary between trials (main effect of trial P = 0.55). Although brachial blood flow tended to decrease after OGTT in both trials (interaction and main effect of time P = 0.61 and P = 0.054, respectively), the decrease in blood flow following OGTT was greater in the Fasting trial than in the Eating trial (main effect of trial, mean difference = − 15.8 mL/min [95%CI = − 25.6 to − 6.0 mL/min], P < 0.01).

Conclusion

Skipping breakfast did not enhance the magnitude of the decrease in FMD following glucose loading, but did accelerate hyperglycemia-induced reduction in brachial blood flow. Current findings suggest that even missing one breakfast has negative impacts on the blood flow regulation of the peripheral conduit arteries in young men who habitually eat breakfast.

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Title: Skipping breakfast does not accelerate the hyperglycemia-induced endothelial dysfunction but reduces blood flow of the brachial artery in young men
Authors: Tatsuki Kamoda
Rintaro Sakamoto
Masaki Katayose
Saki Yamamoto
Toru Neki
Kohei Sato
Erika Iwamoto
Publication date: 19-07-2023
Publisher: Springer Berlin Heidelberg
Keywords: Hyperglycemia
Insulins
Insulins
Published in: European Journal of Applied Physiology / Issue 1/2024
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-023-05273-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Skipping breakfast does not accelerate the hyperglycemia-induced endothelial dysfunction but reduces blood flow of the brachial artery in young men

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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