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European Journal of Applied Physiology

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Open Access 01-03-2020 | Original Article

The impact of acute remote ischaemic preconditioning on cerebrovascular function

Authors: Howard H. Carter, Joseph D. Maxwell, Ylva Hellsten, Andrew Thompson, Dick H. J. Thijssen, Helen Jones

Published in: European Journal of Applied Physiology | Issue 3/2020

Abstract

Purpose

Remote ischaemic preconditioning (RIPC) refers to the protection conferred to tissues and organs via brief periods of ischaemia in a remote vascular territory, including the brain. Recent studies in humans report that RIPC provides neuroprotection against recurrent (ischaemic) stroke. To better understand the ability of RIPC to improve brain health, the present study explored the potential for RIPC to acutely improve cerebrovascular function.

Methods

Eleven young healthy (females n = 6, age; 28.1 ± 3.7 years) and 9 older individuals (females n = 4, age 52.5 ± 6.7 years) at increased risk for stroke (cardiovascular disease risk factors) underwent assessments of cerebrovascular function, assessed by carbon dioxide (CO₂) reactivity and cerebral autoregulation during normo- and hypercapnia (5% CO₂) following 40 mins of bilateral arm RIPC or a sham condition. Squat-to-stand manoeuvres were performed to induce changes in blood pressure to assess cerebral autoregulation (0.10 Hz) and analysed via transfer function.

Results

We found no change in middle cerebral artery velocity or blood pressure across 40 mins of RIPC. Application of RIPC resulted in no change in CO₂ reactivity slopes (sham vs RIPC, 1.97 ± 0.88 vs 2.06 ± 0.69 cm/s/mmHg P = 0.61) or parameters of cerebral autoregulation during normocapnia (sham vs RIPC, normalised gain%, 1.27 ± 0.25 vs 1.22 ± 0.35, P = 0.46).

Conclusion

This study demonstrates that a single bout of RIPC does not influence cerebrovascular function acutely in healthy individuals, or those at increased cardiovascular risk. Given the previously reported protective role of RIPC on stroke recurrence in humans, it is possible that repeated bouts of RIPC may be necessary to impart beneficial effects on cerebrovascular function.

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Title: The impact of acute remote ischaemic preconditioning on cerebrovascular function
Authors: Howard H. Carter
Joseph D. Maxwell
Ylva Hellsten
Andrew Thompson
Dick H. J. Thijssen
Helen Jones
Publication date: 01-03-2020
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 3/2020
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-019-04297-1

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Springer Medicine

The impact of acute remote ischaemic preconditioning on cerebrovascular function

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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