Top

European Journal of Applied Physiology

Published in:

01-09-2018 | Original Article

Temporal dissociation between muscle and pulmonary oxygen uptake kinetics: influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs

Authors: U. Drescher, J. Koschate, L. Thieschäfer, S. Schneider, U. Hoffmann

Published in: European Journal of Applied Physiology | Issue 9/2018

Abstract

Purpose

The aim of the study was to test whether or not the arteriovenous oxygen concentration difference (avDO₂) kinetics at the pulmonary (avDO₂pulm) and muscle (avDO₂musc) levels is significantly different during dynamic exercise.

Methods

A re-analysis involving six publications dealing with kinetic analysis was utilized with an overall sample size of 69 participants. All studies comprised an identical pseudorandom binary sequence work rate (WR) protocol—WR changes between 30 and 80 W—to analyze the kinetic responses of pulmonary (\(\dot {V}{{\text{O}}_2}{\text{pulm}}\)) and muscle (\(\dot {V}{{\text{O}}_2}{\text{musc}}\)) oxygen uptake kinetics as well as those of avDO₂pulm and avDO₂musc.

Results

A significant difference between \(\dot {V}{{\text{O}}_2}{\text{musc}}\) (0.395 ± 0.079) and \(\dot {V}{{\text{O}}_2}{\text{pulm}}\) kinetics (0.330 ± 0.078) was observed (p < 0.001), where the variables showed a significant relationship (r_SP = 0.744, p < 0.001). There were no significant differences between avDO₂musc (0.446 ± 0.077) and avDO₂pulm kinetics (0.451 ± 0.075), which are highly correlated (r = 0.929, p < 0.001).

Conclusion

It is suggested that neither avDO₂pulm nor avDO₂musc kinetic responses seem to be responsible for the differences between estimated \(\dot {V}{{\text{O}}_2}{\text{musc}}\) and measured \(\dot {V}{{\text{O}}_2}{\text{pulm}}\) kinetics. Obviously, the conflation of avDO₂ and perfusion (\({\dot {Q}}\) ) at different points in time and at different physiological levels drive potential differences in \(\dot {V}{{\text{O}}_2}{\text{pulm}}\) and \(\dot {V}{{\text{O}}_2}{\text{musc}}\) kinetics. Therefore, \({\dot {Q}}\) should, in general, be considered whenever oxygen uptake kinetics are analyzed or discussed.

Barstow TJ, Molé PA (1987) Simulation of pulmonary O₂ uptake during exercise transients in humans. J Appl Physiol 63:2253–2261CrossRefPubMed

Barstow TJ, Molé PA (1991) Linear and nonlinear characteristics of oxygen uptake kinetics during heavy exercise. J Appl Physiol 71:2099–2106CrossRefPubMed

Barstow TJ, Lamarra N, Whipp BJ (1990) Modulation of muscle and pulmonary O2 uptakes by circulatory dynamics during exercise. J Appl Physiol 68:979–989CrossRefPubMed

Barstow TJ, Buchthal S, Zanconato S, Cooper DM (1994) Muscle energetics and pulmonary oxygen uptake kinetics during moderate exercise. J Appl Physiol 77:1742–1749CrossRefPubMed

Bearden SE, Moffatt RJ (2001) V′O2 and heart rate kinetics in cycling: transitions from an elevated baseline. J Appl Physiol 90:2081–2087CrossRefPubMed

Beaver WL, Lamarra N, Wasserman K (1981) Breath-by-breath measurement of true alveolar gas exchange. J Appl Physiol 51:1662–1675CrossRefPubMed

Benson AP, Grassi B, Rossiter HB (2013) A validated model of oxygen uptake and circulatory dynamic interactions at exercise onset in humans. J Appl Physiol 115:743–755CrossRefPubMed

Buchheit M, Laursen PB, Ahmaidi S (2009) Effect of prior exercise on pulmonary O2 uptake and estimated muscle capillary blood flow kinetics during moderate-intensity field running in men. J Appl Physiol 107:460–470CrossRefPubMed

Cautero M, Di Prampero PE, Capelli C (2003) New acquisitions in the assessment of breath-by-breath alveolar gas transfer in humans. Eur J Appl Physiol 90:231–241CrossRefPubMed

Cochrane JE, Hughson RL (1992) Computer simulation of O2 transport and utilization mechanisms at the onset of exercise. J Appl Physiol 73:2382–2388CrossRefPubMed

Drescher U, Koschate J, Hoffmann U (2015) Oxygen uptake and heart rate kinetics during dynamic upper and lower body exercise: an investigation by time-series analysis. Eur J Appl Physiol 115:1665–1672CrossRefPubMed

Drescher U, Koschate J, Schiffer T, Hoffmann U (2016) Analysis of cardio-pulmonary and respiratory kinetics in different body positions: impact of venous return on pulmonary measurements. Eur J Appl Physiol 116:1343–1353CrossRefPubMed

Drescher U, Koschate J, Hoffmann U, Schneider S, Werner A (2017a) Effect of acute ambient temperature exposure on cardio-pulmonary and respiratory kinetics in men. Int J Hyperth 34(4):442–454. https://doi.org/10.1080/02656736.2017.1354402 CrossRef

Drescher U, Koschate J, Schiffer T, Schneider S, Hoffmann U (2017b) Analysis of heart rate and oxygen uptake kinetics studied by two different pseudo-random binary sequence work rate amplitudes. Respir Physiol Neurobiol 240:70–80CrossRefPubMed

Drescher U, Schmale R, Koschate J, Thieschäfer L, Schiffer T, Schneider S, Hoffmann U (2018a) Non-invasive estimation of muscle oxygen uptake kinetics with pseudorandom binary sequence and step exercise responses. Eur J Appl Physiol 118(2):429–438CrossRefPubMed

Drescher U, Schefter T, Koschate J, Schiffer T, Brixius K, Schneider S, Hoffmann U (2018b) Oxygen uptake kinetics following six weeks of interval and continuous endurance exercise training—an explorative pilot study. Respir Physiol Neurobiol 247:156–166CrossRefPubMed

Eßfeld D, Hoffmann U, Stegemann J (1991) A model for studying the distortion of muscle oxygen uptake patterns by circulation parameters. Eur J Appl Physiol 62:83–90CrossRef

Fick A (1870) Ueber die Messung des Blutquantums in den Herzventrikeln. Sitz der Physik-Med Ges Wurzburg 2:16

Fortin J, Habenbacher W, Heller A, Hacker A, Grüllenberger R, Innerhofer J, Passatzh H, Wagner C, Haitchi G, Flotzinger D, Pacher R, Wach P (2006) Non-invasive beat-to-beat cardiac output monitoring by an improved method of transthoracic bioimpedance measurement. Comput Biol Med 36:1185–1203CrossRefPubMed

Geigy Scientific Tables (1990) Heart and circulation. Basel, Switzerland

Grassi B, Poole DC, Richardson RS, Knight DR, Erickson BK, Wagner PD (1996) Muscle O2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol 80:988–998CrossRefPubMed

Grassi B, Pogliaghi S, Rampichini S, Quaresima V, Ferrari M, Marconi C, Cerretelli P (2003) Muscle oxygenation and pulmonary gas exchange kinetics during cycling on-transitions in humans. J Appl Physiol 95:149–158CrossRefPubMed

Hoffmann U, Drescher U, Benson AP, Rossiter HB, Eßfeld D (2013) Skeletal muscle VO2 kinetics from cardio-pulmonary measurements: assessing distortions through O2 transport by means of stochastic work-rate signals and circulatory modelling. Eur J Appl Physiol 113:1745–1754CrossRefPubMed

Jones AM, Poole DC (2013) Oxygen uptake kinetics in sport, exercise and medicine. Routledge, Abingdon

Koga S, Poole DC, Shiojiri T, Kondo N, Fukuba Y, Miura A, Barstow TJ (2005) Comparison of oxygen uptake kinetics during knee extension and cycle exercise. Am J Physiol Regul Integr Comp Physiol 288:R212–R220CrossRefPubMed

Krustrup P, Jones AM, Wilkerson DP, Calbet JA, Bangsbo J (2009) Muscular and pulmonary O2 uptake kinetics during moderate- and high-intensity sub-maximal knee-extensor exercise in humans. J Physiol 587:1843–1856CrossRefPubMedPubMedCentral

Lador F, Kenfack MA, Moia C, Cautero M, Morel DR, Capelli C, Feretti G (2006) Simultaneous determination of the kinetics of cardiac output, systemic O2 delivery, and lung O2 uptake at exercise onset in men. Am J Physiol Regul Integr Comp Physiol 290:R1071–R1079CrossRefPubMed

Lai N, Camesasca M, Saidel G, Dash RK, Cabrera ME (2007) Linking pulmonary oxygen uptake, muscle oxygen utilization and cellular metabolism during exercise. Ann Biomed Eng 35:956–969CrossRefPubMedPubMedCentral

Mezzani A, Grassi B, Giordano A, Corrà U, Colombo S, Giannuzzi P (2010) Age-related prolongation of phase I of VO₂ on-kinetics in healthy humans. Am J Physiol Regul Integr Comp Physiol 299:R968–R976CrossRefPubMed

Murias JM, Kowalchuk JM, Paterson DH (2010) Speeding of V′O₂ kinetics with endurance training in old and young men is associated with improved matching of local O₂ delivery to muscle O₂ utilization. J Appl Physiol 108:913–922CrossRefPubMedPubMedCentral

Murias JM, Spencer MD, Kowalchuk JM, Paterson DH (2011) Influence of phase I duration on phase II VO₂ kinetics parameter estimates in older and young adults. Am J Physiol Regul Integr Comp Physiol 301:R218–R224CrossRef

Rossiter HB, Ward SA, Kowalchuk JM, Howe FA, Griffiths JR, Whipp BJ (2002) Dynamic asymmetry of phosphocreatine concentration and O₂ uptake between the on- and off- transients of moderate- and high-intensity exercise in humans. J Physiol 541:991–1002CrossRefPubMedPubMedCentral

Rühle K, Fischer J, Matthys H (1983) Norm values in spiroergometry. Atemwegs- Lungenkrankheiten 9:157–173

Whipp BJ, Ward SA, Lamarra N, Davies JA, Wasserman K (1982) Parameters of ventilatory and gas exchange dynamics during exercise. J Appl Physiol 52:1506–1513CrossRefPubMed

Whipp BJ, Higgenbotham MB, Cobb FC (1996) Estimating exercise stroke volume from asymptotic oxygen pulse in humans. J Appl Physiol 81:2674–2679CrossRefPubMed

Title: Temporal dissociation between muscle and pulmonary oxygen uptake kinetics: influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs
Authors: U. Drescher
J. Koschate
L. Thieschäfer
S. Schneider
U. Hoffmann
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 9/2018
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-018-3916-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Temporal dissociation between muscle and pulmonary oxygen uptake kinetics: influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 9/2018

Methodological issues related to maximal fat oxidation rate during exercise

Comparison of peak oxygen uptake and exercise efficiency between upper-body poling and arm crank ergometry in trained paraplegic and able-bodied participants

Change in VO2max and time trial performance in response to high-intensity interval training prescribed using ventilatory threshold

Influence of full range of motion vs. equalized partial range of motion training on muscle architecture and mechanical properties

Mitigating the bilateral deficit: reducing neural deficits through residual force enhancement and activation reduction

Breathing valve resistance alters physiological responses during a graded exercise test