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European Journal of Applied Physiology

Published in:

01-09-2018 | Original Article

Impact of 60 days of 6° head down tilt bed rest on muscular oxygen uptake and heart rate kinetics: efficacy of a reactive sledge jump countermeasure

Authors: J. Koschate, L. Thieschäfer, U. Drescher, U. Hoffmann

Published in: European Journal of Applied Physiology | Issue 9/2018

Abstract

Purpose

The effects of 60 days of head down tilt bed rest (HDBR) with and without the application of a reactive jump countermeasure were investigated, using a method which enables to discriminate between pulmonary (\(\dot{\text{V}}\)O₂pulm) and muscular (\(\dot{\text{V}}\)O₂musc) oxygen uptake kinetics to control for hemodynamic influences.

Methods

22 subjects were randomly allocated to either a group performing a reactive jumps countermeasure (JUMP; n = 11, male, 29 ± 7 years, 23.9 ± 1.3 kg m^− 2) or a control group (CTRL; n = 11, male, 29 ± 6 years, 23.3 ± 2.0 kg m^− 2). Heart rate (HR) and \(\dot{\text{V}}\)O₂pulm were measured in response to repeated changes in work rate between 30 and 80 W before (BDC-9) and two times after HDBR (R+ 2, R+ 13). Kinetic responses of HR, \(\dot{\text{V}}\)O₂pulm, and \(\dot{\text{V}}\)O₂musc were assessed applying time series analysis. Higher maxima in cross-correlation functions (CCF_max(x)) between work rate and the respective parameter indicate faster kinetics responses. Statistical analysis was performed applying multifactorial analysis of variance.

Results

CCF_max(\(\dot{\text{V}}\)O₂musc) and CCF_max(\(\dot{\text{V}}\)O₂pulm) were not significantly different before and after HDBR (P > 0.05). CCF_max(HR) decreased following bed rest (JUMP: BDC-9: 0.30 ± 0.09 vs. R+ 2: 0.28 ± 0.06 vs. R+13: 0.28 ± 0.07; CTRL: 0.35 ± 0.09 vs. 0.27 ± 0.06 vs. 0.33 ± 0.07 P = 0.025). No significant differences between the groups were observed (P > 0.05). Significant alterations were found for CCF_max of mean arterial blood pressure (mBP) after HDBR (JUMP: BDC-9: 0.21 ± 0.07 vs. R+ 2: 0.30 ± 0.13 vs. R+ 13: 0.28 ± 0.08; CTRL: 0.25 ± 0.07 vs. 0.38 ± 0.13 vs. 0.28 ± 0.08; P = 0.008).

Conclusions

Despite hemodynamic changes, \(\dot{\text{V}}\)O₂ kinetics seem to be preserved for a longer period of HDBR, even without the application of a countermeasure.

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Title: Impact of 60 days of 6° head down tilt bed rest on muscular oxygen uptake and heart rate kinetics: efficacy of a reactive sledge jump countermeasure
Authors: J. Koschate
L. Thieschäfer
U. Drescher
U. Hoffmann
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 9/2018
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-018-3915-y

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Impact of 60 days of 6° head down tilt bed rest on muscular oxygen uptake and heart rate kinetics: efficacy of a reactive sledge jump countermeasure

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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