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European Journal of Applied Physiology

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01-09-2014 | Original Article

The separate and combined effects of hypoxia and sustained recumbency/inactivity on sleep architecture

Authors: Bojan Rojc, Shawnda A. Morrison, Ola Eiken, Igor B. Mekjavic, Leja Dolenc-Grošelj

Published in: European Journal of Applied Physiology | Issue 9/2014

Abstract

Purpose

The objective was to determine the separate and combined effects of hypoxia and inactivity/unloading on sleep architecture during a 10-day period of confinement.

Methods

Ten subjects participated in three 10-day trials in random order: hypoxic ambulatory (HAMB), hypoxic bedrest (HBR), and normoxic bedrest (NBR). During the HAMB and HBR trials, subjects were confined to a hypoxic facility. The hypoxia profile was: simulated altitude of 2,990 m on day 1, 3,380 m on day 2, and 3,881 m on day 3. In the NBR and HBR trials, subjects maintained a horizontal position throughout the confinement period. During each trial, sleep polysomnography was conducted one night prior to (baseline; altitude of facility is 940 m) and on the first (NT1, altitude 2,990 m) and tenth (NT10, altitude 3,881 m) night of the 10-day intervention.

Results

Average time in sleep stage 1 decreased from NT1 to NT10 irrespective of trial. Overall incidence and time spent in periodic breathing increased from NT1 to NT10 in both HAMB and HBR. During NT1, both HAMB and HBR reduced slow-wave sleep and increased light sleep, whereas NBR and HBR increased the number of awakenings/night. There were fewer awakenings during HAMB than NBR.

Conclusions

Acute exposure to both hypoxia and bedrest (HBR) results in greater sleep fragmentation due to more awakenings attributed to bedrest, and lighter sleep as a result of reduced slow wave sleep caused by the hypoxic environment.

Bartsch P, Saltin B (2008) General introduction to altitude adaptation and mountain sickness. Scand J Med Sci Sports 18(Suppl 1):1–10. doi:10.1111/j.1600-0838.2008.00827.x PubMed

Berssenbrugge AD, Dempsey JA, Skatrud JB (1984) Effects of sleep state on ventilatory acclimatization to hypoxia in humans. J Appl Physiol 57(4):1089–1096PubMed

Bodkin DK, Escalera P, Bocam KJ (2006) A human Lunar surface base and infrastructure solution (AIAA 2006-7336). In: 2nd International Space Architecture Symposium (SAS 2006), AIAA Space 2006 Conference & Exposition, San Jose, California, USA. American Institute of Aeronautics and Astronautics, Reston, Virginia

de Aquino Lemos V, Antunes HK, dos Santos RV, Lira FS, Tufik S, de Mello MT (2012) High altitude exposure impairs sleep patterns, mood, and cognitive functions. Psychophysiology 49(9):1298–1306. doi:10.1111/j.1469-8986.2012.01411.x PubMedCrossRef

Debevec T, McDonnell AC, MacDonald IA, Eiken O, Mekjavic IB (2014) Whole body and regional body composition changes following 10-day hypoxic confinement and unloading-inactivity. Appl Physiol Nutr Metab 39:386–395. doi:10.1139/apnm-2013-0278 PubMedCrossRef

Dijk DJ, Neri DF, Wyatt JK, Ronda JM, Riel E, Ritz-De Cecco A, Hughes RJ, Elliott AR, Prisk GK, West JB, Czeisler CA (2001) Sleep, performance, circadian rhythms, and light–dark cycles during two space shuttle flights. Am J Physiol Regul Integr Comp Physiol 281(5):R1647–R1664PubMed

Frost JD Jr, Shumate WH, Salamy JG, Booher CR (1976) Sleep monitoring: the second manned Skylab mission. Aviat Space Environ Med 47(4):372–382PubMed

Gundel A, Polyakov VV, Zulley J (1997) The alteration of human sleep and circadian rhythms during spaceflight. J Sleep Res 6(1):1–8PubMedCrossRef

Hoshikawa M, Uchida S, Sugo T, Kumai Y, Hanai Y, Kawahara T (2007) Changes in sleep quality of athletes under normobaric hypoxia equivalent to 2,000-m altitude: a polysomnographic study. J Appl Physiol 103(6):2005–2011. doi:10.1152/japplphysiol.00315.2007 PubMedCrossRef

Iber C, Ancoli-Israel S, Chesson AL, Quan SF, for the American Academy of Sleep Medicine (2007) The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specification. AASM, Westchester

Jafarian S, Gorouhi F, Taghva A, Lotfi J (2008) High-altitude sleep disturbance: results of the Groningen Sleep Quality Questionnaire survey. Sleep Med 9(4):446–449. doi:10.1016/j.sleep.2007.06.017 PubMedCrossRef

Johnson PL, Edwards N, Burgess KR, Sullivan CE (2010) Sleep architecture changes during a trek from 1,400 to 5,000 m in the Nepal Himalaya. J Sleep Res 19(1 Pt 2):148–156. doi:10.1111/j.1365-2869.2009.00745.x PubMedCrossRef

Karinen H, Peltonen J, Tikkanen H (2008) Prevalence of acute mountain sickness among Finnish trekkers on Mount Kilimanjaro, Tanzania: an observational study. High Alt Med Biol 9(4):301–306. doi:10.1089/ham.2008.1008 PubMedCrossRef

Komada Y, Inoue Y, Mizuno K, Tanaka H, Mishima K, Sato H, Shirakawa S (2006) Effects of acute simulated microgravity on nocturnal sleep, daytime vigilance, and psychomotor performance: comparison of horizontal and 6 degrees head-down bed rest. Percept Mot Skills 103(2):307–317PubMedCrossRef

Kushida CA (2006) Countermeasures for sleep loss and deprivation. Curr Treat Options Neurol 8(5):361–366PubMedCrossRef

Miller JC, Horvath SM (1977) Sleep at altitude. Aviat Space Environ Med 48(7):615–620PubMed

Mizuno K, Asano K, Okudaira N (1993) Sleep and respiration under acute hypobaric hypoxia. Jpn J Physiol 43(2):161–175PubMedCrossRef

Monk TH, Buysse DJ, Billy BD, Kennedy KS, Kupfer DJ (1997) The effects on human sleep and circadian rhythms of 17 days of continuous bedrest in the absence of daylight. Sleep 20(10):858–864PubMed

Monk TH, Buysse DJ, Billy BD, Kennedy KS, Willrich LM (1998) Sleep and circadian rhythms in four orbiting astronauts. J Biol Rhythm 13(3):188–201CrossRef

Nussbaumer-Ochsner Y, Ursprung J, Siebenmann C, Maggiorini M, Bloch KE (2012) Effect of short-term acclimatization to high altitude on sleep and nocturnal breathing. Sleep 35(3):419–423. doi:10.5665/sleep.1708 PubMedCentralPubMed

Pavy-Le Traon A, Heer M, Narici MV, Rittweger J, Vernikos J (2007) From space to Earth: advances in human physiology from 20 years of bed rest studies (1986–2006). Eur J Appl Physiol 101(2):143–194. doi:10.1007/s00421-007-0474-z PubMedCrossRef

Reite M, Jackson D, Cahoon RL, Weil JV (1975) Sleep physiology at high altitude. Electroencephalogr Clin Neurophysiol 38(5):463–471PubMedCrossRef

Salvaggio A, Insalaco G, Marrone O, Romano S, Braghiroli A, Lanfranchi P, Patruno V, Donner CF, Bonsignore G (1998) Effects of high-altitude periodic breathing on sleep and arterial oxyhaemoglobin saturation. Eur Respir J 12(2):408–413. doi:10.1183/09031936.98.12020408 PubMedCrossRef

Scheuring R, Conkin J, Jones JA, Gernhard ML (2008) Risk assessment of physiological effects of atmospheric composition and pressure in Constellation vehicles. Acta Astronaut 63:727–739. doi:10.1016/j.actaastro.2008.02.009 CrossRef

Szymczak RK, Sitek EJ, Slawek JW, Basinski A, Sieminski M, Wieczorek D (2009) Subjective sleep quality alterations at high altitude. Wilderness Environ Med 20(4):305–310. doi:10.1580/1080-6032-020.004.0305 PubMedCrossRef

Windsor JS, Rodway GW (2012) Sleep disturbance at altitude. Curr Opin Pulm Med 18(6):554–560. doi:10.1097/MCP.0b013e328359129f PubMedCrossRef

Title: The separate and combined effects of hypoxia and sustained recumbency/inactivity on sleep architecture
Authors: Bojan Rojc
Shawnda A. Morrison
Ola Eiken
Igor B. Mekjavic
Leja Dolenc-Grošelj
Publication date: 01-09-2014
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 9/2014
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-014-2909-7

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The separate and combined effects of hypoxia and sustained recumbency/inactivity on sleep architecture

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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