Published in:
01-05-2013 | Original Article
Low total haemoglobin mass, blood volume and aerobic capacity in men with type 1 diabetes
Authors:
Anne S. Koponen, Juha E. Peltonen, Marja K. Päivinen, Jyrki M. Aho, Harriet J. Hägglund, Arja L. Uusitalo, Harri J. Lindholm, Heikki O. Tikkanen
Published in:
European Journal of Applied Physiology
|
Issue 5/2013
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Abstract
Blood O2 carrying capacity affects aerobic capacity (VO2max). Patients with type 1 diabetes have a risk for anaemia along with renal impairment, and they often have low VO2max. We investigated whether total haemoglobin mass (tHb-mass) and blood volume (BV) differ in men with type 1 diabetes (T1D, n = 12) presently without complications and in healthy men (CON, n = 23) (age-, anthropometry-, physical activity-matched), to seek an explanation for low VO2max. We determined tHb-mass, BV, haemoglobin concentration ([Hb]), and VO2max in T1D and CON. With similar (mean ± SD) [Hb] (144 vs. 145 g l−1), T1D had lower tHb-mass (10.1 ± 1.4 vs. 11.0 ± 1.1 g kg−1, P < 0.05), BV (76.8 ± 9.5 vs. 83.5 ± 8.3 ml kg−1, P < 0.05) and VO2max (35.4 ± 4.8 vs. 44.9 ± 7.5 ml kg−1 min−1, P < 0.001) than CON. VO2max correlated with tHb-mass and BV both in T1D (r = 0.71, P < 0.01 and 0.67, P < 0.05, respectively) and CON (r = 0.54, P < 0.01 and 0.66, P < 0.001, respectively), but not with [Hb]. Linear regression slopes were shallower in T1D than CON both between VO2max and tHb-mass (2.4 and 3.6 ml kg−1 min−1 vs. g kg−1, respectively) and VO2max and BV (0.3 and 0.6 ml kg−1 min−1 vs. g kg−1, respectively), indicating that T1D were unable to reach similar VO2max than CON at a given tHb-mass and BV. In conclusion, low tHb-mass and BV partly explained low VO2max in T1D and may provide early and more sensitive markers of blood O2 carrying capacity than [Hb] alone.