Skip to main content
Top
Published in: European Journal of Applied Physiology 4/2013

01-04-2013 | Original Article

Long-term creatine supplementation improves muscular performance during resistance training in older women

Authors: Andreo Fernando Aguiar, Renata Selvatici Borges Januário, Raymundo Pires Junior, Aline Mendes Gerage, Fábio Luiz Cheche Pina, Matheus Amarante do Nascimento, Carlos Roberto Padovani, Edilson Serpeloni Cyrino

Published in: European Journal of Applied Physiology | Issue 4/2013

Login to get access

Abstract

This study examined the effects of long-term creatine supplementation combined with resistance training (RT) on the one-repetition maximum (1RM) strength, motor functional performance (e.g., 30-s chair stand, arm curl, and getting up from lying on the floor tests) and body composition (e.g., fat-free mass, muscle mass, and % body fat using DEXA scans) in older women. Eighteen healthy women (64.9 ± 5.0 years) were randomly assigned in a double-blind fashion to either a creatine (CR, N = 9) or placebo (PL, N = 9) group. Both groups underwent a 12-week RT program (3 days week−1), consuming an equivalent amount of either creatine (5.0 g day−1) or placebo (maltodextrin). After 12 week, the CR group experienced a greater (P < 0.05) increase (Δ%) in training volume (+164.2), and 1RM bench press (+5.1), knee extension (+3.9) and biceps curl (+8.8) performance than the PL group. Furthermore, CR group gained significantly more fat-free mass (+3.2) and muscle mass (+2.8) and were more efficient in performing submaximal-strength functional tests than the PL group. No changes (P > 0.05) in body mass or % body fat were observed from pre- to post-test in either group. These results indicate that long-term creatine supplementation combined with RT improves the ability to perform submaximal-strength functional tasks and promotes a greater increase in maximal strength, fat-free mass and muscle mass in older women.
Literature
go back to reference Baechle TR, Earle RW (2008) Resistance training and spotting techniques. In: Earle R, Baechle T (eds) Essentials of strength and conditioning: national strength and conditioning association, 3rd edn. Human Kinetics, Champaign, pp 326–376 Baechle TR, Earle RW (2008) Resistance training and spotting techniques. In: Earle R, Baechle T (eds) Essentials of strength and conditioning: national strength and conditioning association, 3rd edn. Human Kinetics, Champaign, pp 326–376
go back to reference Bamman MM, Hill VJ, Adams GR, Haddad F, Wetzstein CJ, Gower BA, Ahmed A, Hunter GR (2003) Gender differences in resistance-training-induced myofiber hypertrophy among older adults. J Gerontol A Biol Sci Med Sci 58(2):108–116PubMedCrossRef Bamman MM, Hill VJ, Adams GR, Haddad F, Wetzstein CJ, Gower BA, Ahmed A, Hunter GR (2003) Gender differences in resistance-training-induced myofiber hypertrophy among older adults. J Gerontol A Biol Sci Med Sci 58(2):108–116PubMedCrossRef
go back to reference Beltran B, Cuadrado C, Martin ML, Carbajal A, Moreiras O (2001) Activities of daily living in the Spanish elderly. Association with mortality. J Nutr Health Aging 5(4):259–260PubMed Beltran B, Cuadrado C, Martin ML, Carbajal A, Moreiras O (2001) Activities of daily living in the Spanish elderly. Association with mortality. J Nutr Health Aging 5(4):259–260PubMed
go back to reference Bermon S, Venembre P, Sachet C, Valour S, Dolisi C (1998) Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults. Acta Physiol Scand 164(2):147–155PubMedCrossRef Bermon S, Venembre P, Sachet C, Valour S, Dolisi C (1998) Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults. Acta Physiol Scand 164(2):147–155PubMedCrossRef
go back to reference Bohannon RW (1995) Sit-to-stand test for measuring performance of lower extremity muscles. Percept Mot Skills 80(1):163–166PubMedCrossRef Bohannon RW (1995) Sit-to-stand test for measuring performance of lower extremity muscles. Percept Mot Skills 80(1):163–166PubMedCrossRef
go back to reference Brose A, Parise G, Tarnopolsky MA (2003) Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J Gerontol A Biol Sci Med Sci 58(1):11–19PubMedCrossRef Brose A, Parise G, Tarnopolsky MA (2003) Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J Gerontol A Biol Sci Med Sci 58(1):11–19PubMedCrossRef
go back to reference Campbell WW, Crim MC, Young VR, Evans WJ (1994) Increased energy requirements and changes in body composition with resistance training in older adults. Am J Clin Nutr 60(2):167–175PubMed Campbell WW, Crim MC, Young VR, Evans WJ (1994) Increased energy requirements and changes in body composition with resistance training in older adults. Am J Clin Nutr 60(2):167–175PubMed
go back to reference Canete S, San Juan AF, Perez M, Gomez-Gallego F, Lopez-Mojares LM, Earnest CP, Fleck SJ, Lucia A (2006) Does creatine supplementation improve functional capacity in elderly women? J Strength Cond Res 20(1):22–28PubMed Canete S, San Juan AF, Perez M, Gomez-Gallego F, Lopez-Mojares LM, Earnest CP, Fleck SJ, Lucia A (2006) Does creatine supplementation improve functional capacity in elderly women? J Strength Cond Res 20(1):22–28PubMed
go back to reference Casey A, Greenhaff PL (2000) Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance? Am J Clin Nutr 72(2):607S–617SPubMed Casey A, Greenhaff PL (2000) Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance? Am J Clin Nutr 72(2):607S–617SPubMed
go back to reference Charette SL, McEvoy L, Pyka G, Snow-Harter C, Guido D, Wiswell RA, Marcus R (1991) Muscle hypertrophy response to resistance training in older women. J Appl Physiol 70(5):1912–1916PubMed Charette SL, McEvoy L, Pyka G, Snow-Harter C, Guido D, Wiswell RA, Marcus R (1991) Muscle hypertrophy response to resistance training in older women. J Appl Physiol 70(5):1912–1916PubMed
go back to reference Chodzko-Zajko WJ, Proctor DN, Fiatarone Singh MA, Minson CT, Nigg CR, Salem GJ, Skinner JS (2009) American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc 41(7):1510–1530PubMedCrossRef Chodzko-Zajko WJ, Proctor DN, Fiatarone Singh MA, Minson CT, Nigg CR, Salem GJ, Skinner JS (2009) American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc 41(7):1510–1530PubMedCrossRef
go back to reference Chrusch MJ, Chilibeck PD, Chad KE, Davison KS, Burke DG (2001) Creatine supplementation combined with resistance training in older men. Med Sci Sports Exerc 33(12):2111–2117PubMedCrossRef Chrusch MJ, Chilibeck PD, Chad KE, Davison KS, Burke DG (2001) Creatine supplementation combined with resistance training in older men. Med Sci Sports Exerc 33(12):2111–2117PubMedCrossRef
go back to reference Cribb PJ, Hayes A (2006) Effects of supplement timing and resistance exercise on skeletal muscle hypertrophy. Med Sci Sports Exerc 38(11):1918–1925PubMedCrossRef Cribb PJ, Hayes A (2006) Effects of supplement timing and resistance exercise on skeletal muscle hypertrophy. Med Sci Sports Exerc 38(11):1918–1925PubMedCrossRef
go back to reference Csuka M, McCarty DJ (1985) Simple method for measurement of lower extremity muscle strength. Am J Med 78(1):77–81PubMedCrossRef Csuka M, McCarty DJ (1985) Simple method for measurement of lower extremity muscle strength. Am J Med 78(1):77–81PubMedCrossRef
go back to reference Doherty TJ (2003) Invited review: aging and sarcopenia. J Appl Physiol 95(4):1717–1727PubMed Doherty TJ (2003) Invited review: aging and sarcopenia. J Appl Physiol 95(4):1717–1727PubMed
go back to reference Eijnde BO, Van Leemputte M, Goris M, Labarque V, Taes Y, Verbessem P, Vanhees L, Ramaekers M, Vanden Eynde B, Van Schuylenbergh R, Dom R, Richter EA, Hespel P (2003) Effects of creatine supplementation and exercise training on fitness in men 55–75 yr old. J Appl Physiol 95(2):818–828PubMed Eijnde BO, Van Leemputte M, Goris M, Labarque V, Taes Y, Verbessem P, Vanhees L, Ramaekers M, Vanden Eynde B, Van Schuylenbergh R, Dom R, Richter EA, Hespel P (2003) Effects of creatine supplementation and exercise training on fitness in men 55–75 yr old. J Appl Physiol 95(2):818–828PubMed
go back to reference Esmarck B, Andersen JL, Olsen S, Richter EA, Mizuno M, Kjaer M (2001) Timing of postexercise protein intake is important for muscle hypertrophy with resistance training in elderly humans. J Physiol 535(1):301–311PubMedCrossRef Esmarck B, Andersen JL, Olsen S, Richter EA, Mizuno M, Kjaer M (2001) Timing of postexercise protein intake is important for muscle hypertrophy with resistance training in elderly humans. J Physiol 535(1):301–311PubMedCrossRef
go back to reference Ferguson TB, Syrotuik DG (2006) Effects of creatine monohydrate supplementation on body composition and strength indices in experienced resistance trained women. J Strength Cond Res 20(4):939–946PubMed Ferguson TB, Syrotuik DG (2006) Effects of creatine monohydrate supplementation on body composition and strength indices in experienced resistance trained women. J Strength Cond Res 20(4):939–946PubMed
go back to reference Forsberg AM, Nilsson E, Werneman J, Bergström J, Hultman E (1991) Muscle composition in relation to age and sex. Clin Sci 81(2):249–256PubMed Forsberg AM, Nilsson E, Werneman J, Bergström J, Hultman E (1991) Muscle composition in relation to age and sex. Clin Sci 81(2):249–256PubMed
go back to reference Gotshalk LA, Volek JS, Staron RS, Denegar CR, Hagerman FC, Kraemer WJ (2002) Creatine supplementation improves muscular performance in older men. Med Sci Sports Exerc 34(3):537–543PubMedCrossRef Gotshalk LA, Volek JS, Staron RS, Denegar CR, Hagerman FC, Kraemer WJ (2002) Creatine supplementation improves muscular performance in older men. Med Sci Sports Exerc 34(3):537–543PubMedCrossRef
go back to reference Gotshalk LA, Kraemer WJ, Mendonca MA, Vingren JL, Kenny AM, Spiering BA, Hatfield DL, Fragala MS, Volek JS (2008) Creatine supplementation improves muscular performance in older women. Eur J Appl Physiol 102(2):223–231PubMedCrossRef Gotshalk LA, Kraemer WJ, Mendonca MA, Vingren JL, Kenny AM, Spiering BA, Hatfield DL, Fragala MS, Volek JS (2008) Creatine supplementation improves muscular performance in older women. Eur J Appl Physiol 102(2):223–231PubMedCrossRef
go back to reference Green AL, Hultman E, Macdonald IA, Sewell DA, Greenhaff PL (1996a) Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 271(5):821–826 Green AL, Hultman E, Macdonald IA, Sewell DA, Greenhaff PL (1996a) Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 271(5):821–826
go back to reference Green AL, Simpson EJ, Littlewood JJ, Macdonald IA, Greenhaff PL (1996b) Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acta Physiol Scand 158(2):195–202PubMedCrossRef Green AL, Simpson EJ, Littlewood JJ, Macdonald IA, Greenhaff PL (1996b) Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acta Physiol Scand 158(2):195–202PubMedCrossRef
go back to reference Harris RC, Soderlund K, Hultman E (1992) Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci 83(3):367–374PubMed Harris RC, Soderlund K, Hultman E (1992) Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci 83(3):367–374PubMed
go back to reference Hunter GR, McCarthy JP, Bamman MM (2004) Effects of resistance training on older adults. Sports Med 34(5):329–348PubMedCrossRef Hunter GR, McCarthy JP, Bamman MM (2004) Effects of resistance training on older adults. Sports Med 34(5):329–348PubMedCrossRef
go back to reference Jakobi JM, Rice CL, Curtin SV, Marsh GD (2001) Neuromuscular properties and fatigue in older men following acute creatine supplementation. Eur J Appl Physiol 84(4):321–328PubMedCrossRef Jakobi JM, Rice CL, Curtin SV, Marsh GD (2001) Neuromuscular properties and fatigue in older men following acute creatine supplementation. Eur J Appl Physiol 84(4):321–328PubMedCrossRef
go back to reference Johnson RA, Wichern DW (2002) Applied multivariate analysis, 5th edn. Prentice-Hall, Upper Saddle River Johnson RA, Wichern DW (2002) Applied multivariate analysis, 5th edn. Prentice-Hall, Upper Saddle River
go back to reference Kim J, Heshka S, Gallagher D, Kotler DP, Mayer L, Albu J, Shen W, Freda PU, Heymsfield SB (2004) Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults. J Appl Physiol 97(2):655–660PubMedCrossRef Kim J, Heshka S, Gallagher D, Kotler DP, Mayer L, Albu J, Shen W, Freda PU, Heymsfield SB (2004) Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults. J Appl Physiol 97(2):655–660PubMedCrossRef
go back to reference Kuriansky JB, Gurland B (1976) Performance tests of activities of daily living. Int J Aging Hum Dev 7:343–352CrossRef Kuriansky JB, Gurland B (1976) Performance tests of activities of daily living. Int J Aging Hum Dev 7:343–352CrossRef
go back to reference Mesa JL, Ruiz JR, González-Gross MM, Gutiérrez Sáinz A, Castillo Garzón MJ (2002) Oral creatine supplementation and skeletal muscle metabolism in physical exercise. Sports Med 32(14):903–944PubMedCrossRef Mesa JL, Ruiz JR, González-Gross MM, Gutiérrez Sáinz A, Castillo Garzón MJ (2002) Oral creatine supplementation and skeletal muscle metabolism in physical exercise. Sports Med 32(14):903–944PubMedCrossRef
go back to reference Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA (2000) Acute creatine loading increases fat-free mass, but not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sport Exerc 32(2):291–296CrossRef Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA (2000) Acute creatine loading increases fat-free mass, but not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sport Exerc 32(2):291–296CrossRef
go back to reference Newton RU, Hakkinen K, Hakkinen A, McCormick M, Volek J, Kraemer WJ (2002) Mixed-methods resistance training increases power and strength of young and older men. Med Sci Sports Exerc 34(8):1367–1375PubMedCrossRef Newton RU, Hakkinen K, Hakkinen A, McCormick M, Volek J, Kraemer WJ (2002) Mixed-methods resistance training increases power and strength of young and older men. Med Sci Sports Exerc 34(8):1367–1375PubMedCrossRef
go back to reference Prior BM, Cureton KJ, Modlesky CM, Evans EM, Sloniger MA, Saunders M, Lewis RD (1997) In vivo validation of whole body composition estimates from dual-energy X-ray absorptiometry. J Appl Physiol 83:623–630PubMed Prior BM, Cureton KJ, Modlesky CM, Evans EM, Sloniger MA, Saunders M, Lewis RD (1997) In vivo validation of whole body composition estimates from dual-energy X-ray absorptiometry. J Appl Physiol 83:623–630PubMed
go back to reference Rawson ES, Clarkson PM (2000) Acute creatine supplementation in older men. Int J Sports Med 21(1):71–75PubMedCrossRef Rawson ES, Clarkson PM (2000) Acute creatine supplementation in older men. Int J Sports Med 21(1):71–75PubMedCrossRef
go back to reference Rawson ES, Clarkson PM, Price TB, Miles MP (2002) Differential response of muscle phosphocreatine to creatine supplementation in young and old subjects. Acta Physiol Scand 174(1):57–65PubMedCrossRef Rawson ES, Clarkson PM, Price TB, Miles MP (2002) Differential response of muscle phosphocreatine to creatine supplementation in young and old subjects. Acta Physiol Scand 174(1):57–65PubMedCrossRef
go back to reference Rikli R, Jones J (1999a) Development and validation of a function fitness test for community-residing older adults. J Aging Phys Activ 7(2):129–161 Rikli R, Jones J (1999a) Development and validation of a function fitness test for community-residing older adults. J Aging Phys Activ 7(2):129–161
go back to reference Rikli R, Jones J (1999b) Functional fitness normative scores for community-residing older adults, ages 60-94J. Aging Phys Activ 7(2):162–181 Rikli R, Jones J (1999b) Functional fitness normative scores for community-residing older adults, ages 60-94J. Aging Phys Activ 7(2):162–181
go back to reference Smith SA, Montain SJ, Matott RP, Zientara GP, Jolesz FA, Fielding RA (1998) Creatine supplementation and age influence muscle metabolism during exercise. J Appl Physiol 85(4):1349–1356PubMed Smith SA, Montain SJ, Matott RP, Zientara GP, Jolesz FA, Fielding RA (1998) Creatine supplementation and age influence muscle metabolism during exercise. J Appl Physiol 85(4):1349–1356PubMed
go back to reference Stout JR, Sue Graves B, Cramer JT, Goldstein ER, Costa PB, Smith AE, Walter AA (2007) Effects of creatine supplementation on the onset of neuromuscular fatigue threshold and muscle strength in elderly men and women (64–86 years). J Nutr Health Aging 11(6):459–464PubMed Stout JR, Sue Graves B, Cramer JT, Goldstein ER, Costa PB, Smith AE, Walter AA (2007) Effects of creatine supplementation on the onset of neuromuscular fatigue threshold and muscle strength in elderly men and women (64–86 years). J Nutr Health Aging 11(6):459–464PubMed
go back to reference Taaffe DR, Pruitt L, Pyka G, Guido D, Marcus R (1996) Comparative effects of high- and low-intensity resistance training on thigh muscle strength, fiber area, and tissue composition in elderly women. Clin Physiol 16(4):381–392PubMedCrossRef Taaffe DR, Pruitt L, Pyka G, Guido D, Marcus R (1996) Comparative effects of high- and low-intensity resistance training on thigh muscle strength, fiber area, and tissue composition in elderly women. Clin Physiol 16(4):381–392PubMedCrossRef
go back to reference Tarnopolsky MA, MacLennan DP (2000) Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr Exerc Metab 10(4):452–463PubMed Tarnopolsky MA, MacLennan DP (2000) Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr Exerc Metab 10(4):452–463PubMed
go back to reference Trappe S, Godard M, Gallagher P, Carroll C, Rowden G, Porter D (2001) Resistance training improves single muscle fiber contractile function in older women. Am J Physiol Cell Physiol 281(2):C398–C406PubMed Trappe S, Godard M, Gallagher P, Carroll C, Rowden G, Porter D (2001) Resistance training improves single muscle fiber contractile function in older women. Am J Physiol Cell Physiol 281(2):C398–C406PubMed
go back to reference Vandenberghe K, Gillis N, Van Leemputte M, Van Hecke P, Vanstapel F, Hespel P (1996) Caffeine counteracts the ergogenic action of muscle creatine loading. J Appl Physiol 80(2):452–457PubMed Vandenberghe K, Gillis N, Van Leemputte M, Van Hecke P, Vanstapel F, Hespel P (1996) Caffeine counteracts the ergogenic action of muscle creatine loading. J Appl Physiol 80(2):452–457PubMed
go back to reference Vandenberghe K, Goris M, Van Hecke P, Van Leemputte M, Vangerven L, Hespel P (1997) Long-term creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol 83(6):2055–2063PubMed Vandenberghe K, Goris M, Van Hecke P, Van Leemputte M, Vangerven L, Hespel P (1997) Long-term creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol 83(6):2055–2063PubMed
go back to reference Volek JS, Duncan ND, Mazzetti SA, Staron RS, Patukian M, Gomez AL, Pearson DR, Fink WJ, Kraemer WJ (1999) Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med Sci Sport Exerc 31(8):1147–1156CrossRef Volek JS, Duncan ND, Mazzetti SA, Staron RS, Patukian M, Gomez AL, Pearson DR, Fink WJ, Kraemer WJ (1999) Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med Sci Sport Exerc 31(8):1147–1156CrossRef
go back to reference Von Strauss E, Agüero-Torres H, Kåreholt I, Winblad B, Fratiglioni L (2003) Women are more disabled in basic activities of daily living than men only in very advanced ages: a study on disability, morbidity, and mortality from the Kungsholmen Project. J Clin Epidemiol 56(7):669–677CrossRef Von Strauss E, Agüero-Torres H, Kåreholt I, Winblad B, Fratiglioni L (2003) Women are more disabled in basic activities of daily living than men only in very advanced ages: a study on disability, morbidity, and mortality from the Kungsholmen Project. J Clin Epidemiol 56(7):669–677CrossRef
go back to reference Willoughby DS, Rosene J (2001) Effects of oral creatine and resistance training on myosin heavy chain expression. Med Sci Sports Exerc 33(10):1674–1681PubMedCrossRef Willoughby DS, Rosene J (2001) Effects of oral creatine and resistance training on myosin heavy chain expression. Med Sci Sports Exerc 33(10):1674–1681PubMedCrossRef
go back to reference Yarasheski KE, Zachwieja JJ, Campbell JA, Bier DM (1995) Effect of growth hormone and resistance exercise on muscle growth and strength in older men. Am J Physiol 268(2):E268–E276PubMed Yarasheski KE, Zachwieja JJ, Campbell JA, Bier DM (1995) Effect of growth hormone and resistance exercise on muscle growth and strength in older men. Am J Physiol 268(2):E268–E276PubMed
go back to reference Yarasheski KE, Pak-Loduca J, Hasten DL, Obert KA, Brown MB, Sinacore DR (1999) Resistance exercise training increases mixed muscle protein synthesis rate in frail women and men ≥ 76 yr old. Am J Physiol 277(1):E118–E125PubMed Yarasheski KE, Pak-Loduca J, Hasten DL, Obert KA, Brown MB, Sinacore DR (1999) Resistance exercise training increases mixed muscle protein synthesis rate in frail women and men ≥ 76 yr old. Am J Physiol 277(1):E118–E125PubMed
go back to reference Zar JH (1999) Biostatistical analysis, 4th edn. Prentice-Hall, Upper Saddle River Zar JH (1999) Biostatistical analysis, 4th edn. Prentice-Hall, Upper Saddle River
Metadata
Title
Long-term creatine supplementation improves muscular performance during resistance training in older women
Authors
Andreo Fernando Aguiar
Renata Selvatici Borges Januário
Raymundo Pires Junior
Aline Mendes Gerage
Fábio Luiz Cheche Pina
Matheus Amarante do Nascimento
Carlos Roberto Padovani
Edilson Serpeloni Cyrino
Publication date
01-04-2013
Publisher
Springer-Verlag
Published in
European Journal of Applied Physiology / Issue 4/2013
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-012-2514-6

Other articles of this Issue 4/2013

European Journal of Applied Physiology 4/2013 Go to the issue