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01-09-2011 | Original Article

Impact of heat and pollution on oxidative stress and CC16 secretion after 8 km run

Authors: Elisa Couto Gomes, Vicki Stone, Geraint Florida-James

Published in: European Journal of Applied Physiology | Issue 9/2011

Abstract

To investigate the acute effect of a hot, humid and ozone-polluted (O₃) environment on lung inflammation and oxidative tress of runners performing 8 km time trial run. Using a single-blinded randomized design, 10 male athletes (mean\( \dot{V}{\text{O}}_{2\max } \)= 64.4 mlO₂ kg⁻¹ min⁻¹, SD = 4.4) took part in a time trial run in four different environmental conditions: 20°C + 50% relative humidity (rh) (Control); 20°C + 50% rh + 0.10 ppm O₃ (Control + O₃); 31°C + 70% rh (Heat); 31°C + 70% rh + 0.10 ppm O₃ (Heat + O₃). Blood samples and nasal lavage were collected post-exercise and analyzed for inflammatory, epithelial damage and oxidative stress markers. Data were analyzed using repeated measures ANOVA with Tukey’s post hoc test. A significant increase in CC16 concentration (P < 0.05) and GSH/protein concentration (P < 0.05) in the upper respiratory airways was observed following the 8 km run in the Heat + O₃ trial compared with the control trial. There were no differences in the neutrophil counts between trials. No differences were observed for the other antioxidants analyzed. A hot, humid and ozone-polluted environment (0.1 ppm) elicits an early epithelial damage and antioxidant protection process in the upper respiratory airways of athletes immediately after performing 8 km time trial run.

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Title: Impact of heat and pollution on oxidative stress and CC16 secretion after 8 km run
Authors: Elisa Couto Gomes
Vicki Stone
Geraint Florida-James
Publication date: 01-09-2011
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 9/2011
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-011-1839-x

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Impact of heat and pollution on oxidative stress and CC16 secretion after 8 km run

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