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01-01-2010 | Original Article

Hypoxic training increases metabolic enzyme activity and composition of α-myosin heavy chain isoform in rat ventricular myocardium

Authors: Ming-Chun Cai, Qing-Yuan Huang, Wei-Gong Liao, Zhou Wu, Fu-Yu Liu, Yu-Qi Gao

Published in: European Journal of Applied Physiology | Issue 1/2010

Abstract

Cardiac muscle adaptation is essential for maintaining physical capacity after ascending to high altitude. This study examines the effects of high altitude training on myocardial metabolic enzyme activity and composition of α-myosin heavy chain (MHC). Rats were randomly divided into normobaric sedentary (NS) and training (NT) groups, and hypobaric sedentary (HS) and training (HT) groups. HS and HT rats were exposed to hypobaric hypoxia (simulated 4,000–5,000 m) for 5 weeks (24 h/day), and HT rats simultaneously received swim training. Hypoxia exposure for 5 weeks led to a decrease in succinate dehydrogenase (SDH) and citrate synthase (CS) activities in the left ventricle (LV), and a decrease in CS, hexokinase (HK) and total lactate dehydrogenase (LDH) activities in the right ventricle (RV) (p < 0.05, HS vs. NS). Furthermore, 1 h/day swim training during hypoxia exposure enhanced the CS activity in LV and the SDH and CS activities in RV (p < 0.05, HT vs. HS). The percentages of α-MHC in both ventricles in HT were higher than those in HS (p < 0.05). We conclude that exercise training at high altitude is beneficial for cardiac muscle adaptation to hypoxia by increasing activities of enzymes and percentage of α-MHC. This may contribute to improved cardiac function and work capacity at high altitude.

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Title: Hypoxic training increases metabolic enzyme activity and composition of α-myosin heavy chain isoform in rat ventricular myocardium
Authors: Ming-Chun Cai
Qing-Yuan Huang
Wei-Gong Liao
Zhou Wu
Fu-Yu Liu
Yu-Qi Gao
Publication date: 01-01-2010
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 1/2010
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-009-1189-0

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Hypoxic training increases metabolic enzyme activity and composition of α-myosin heavy chain isoform in rat ventricular myocardium

Abstract

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