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01-04-2009 | Original Article

Association of angiotensin-converting enzyme insertion/deletion polymorphism with obesity, cardiovascular risk factors and exercise-mediated changes in Korean women

Author: Kijin Kim

Published in: European Journal of Applied Physiology | Issue 6/2009

Abstract

This study examined whether the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism is associated with obesity, cardiovascular risk factors and 12-week exercise-mediated changes in Korean women. A total of 105 subjects were divided into three groups as II, ID and DD genotype groups based upon ACE I/D genotypes. Body composition and cardiovascular risk factors were compared among the three groups, and the association of ACE I/D genotypes with obesity and hypertension was evaluated. Total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels were higher (P < 0.05) in the DD genotype than in II or ID genotypes. D allele frequency in ACE I/D gene had a higher (P = 0.063) trend in the hypertensive group than the normotensive group. The DD genotype had a trend to develop (odds ratio 4.032, P = 0.086) more hypertension than the II genotype. The II and ID genotypes showed a significant (P < 0.05) decrease in intima media thickness of the carotid artery after an exercise intervention, whereas the DD genotype showed an increase. In conclusion, there is a trend towards association of ACE I/D polymorphism with hypertension but not with obesity. Exercise-mediated changes did not differ significantly among genotypes except IMTCA.

Agerholm-Larsen B, Nordestgaard BG, Tybjaerg-Hansen A (2000) ACE gene polymorphism in cardiovascular disease: meta-analyses of small and large studies in whites. Arterioscler Thromb Vasc Biol 20:484–492PubMed

Balkestein EJ, Staessen JA, Wang J-G, van der Heijden-Spek JJ, Van Bortel LM, Barlassina C, Bianchi G, Brand E, Herrmann S-M, Struijker-Boudier HA (2001) Carotid and femoral artery stiffness in relation to three candidate genes in a white population. Hypertension 38:1190–1197. doi:10.1161/hy1101.095992 PubMedCrossRef

Bengtsson K, Orho-Melander M, Lindblad U, Melander O, Bog-Hansen E, Ranstam J, Rastam L, Groop L (1999) Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and Diabetes Project. J Hypertens 17:1569–1575. doi:10.1097/00004872-199917110-00010 PubMedCrossRef

Brown NJ, Blais C, Gandhi SK, Adam A (1998) ACE insertion/deletion genotype affects bradykinin metabolism. J Cardiovasc Pharmacol 32:373–377. doi:10.1097/00005344-199809000-00006 PubMedCrossRef

Butler R (2000) The DD-ACE genotype and cardiovascular disease. Pharmacogenomics 1:153–167. doi:10.1517/14622416.1.2.153 PubMedCrossRef

Cooper RS, Rotimi CN, Kaufman JS, Owaje EE, Fraser H, Forrester T, Wilks R, Riste LK, Cruickshank JK (1997) Prevalence of NIDDM among populations of the African diaspora. Diabetes Care 20:343–348. doi:10.2337/diacare.20.3.343 PubMedCrossRef

Dengel DR, Brown MD, Ferrell RE, Reynolds TH, Supino MA (2002) Exercise-induced changes in insulin action are associated with ACE gene polymorphisms in older adults. Physiol Genomics 11:73–80PubMed

Engeli S, Negrel R, Sharma AM (2000) Physiology and pathophysiology of the adipose tissue renin-angiotensin system. Hypertension 35:1270–1277PubMed

Engeli S, Schling P, Gorzelniak K, Boschmann M, Janke J, Ailhaud G, Teboul M, Massiera F, Sharma AM (2003) The adipose-tissue renin angiotensin-aldosterone system: role in the metabolic syndrome? Int J Biochem Cell Biol 35:80–825. doi:10.1016/S1357-2725(02)00311-4 CrossRef

Engeli S, Bohnke J, Gorzelniak K, Janke J, Schling P, Bader M, Luft FC, Sharma AM (2005) Weight loss and the renin–angiotenisn-aldosterone system. Hypertension 45:356–362. doi:10.1161/01.HYP.0000154361.47683.d3 PubMedCrossRef

Feng Y, Niu T, Xu X, Chen C, Li Q, Qian R, Wang G, Xu X (2002) Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes. Diabetes 51:1986–1988. doi:10.2337/diabetes.51.6.1986 PubMedCrossRef

Fogarty DG, Maxwell AP, Doherty CC, Hughes AE, Nevin NC (1994) ACE gene typing. Lancet 343:851. doi:10.1016/S0140-6736(94)92050-8 LetterPubMedCrossRef

Friedewald WT, Levy RI, Fredreickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502PubMed

Fuentes RM, Perola M, Nissinen A, Tuomilehto J (2002) ACE gene and physical activity, blood pressure, and hypertension: a population study in Finland. J Appl Physiol 92:2508–2512PubMed

Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC, Spertus JA, Costa F (2005) Diagnosis and management of the metabolic syndrome. Circulation 112:2735–2752. doi:10.1161/CIRCULATIONAHA.105.169404 PubMedCrossRef

Hagberg JM, Ferrell RE, Dengel DR, Wilund KR (1999) Exercise training-induced blood pressure and plasma lipid improvements in hypertensives may be genotype dependent. Hypertension 34:18–23PubMed

Harrap SB, Tzourio C, Cambien F, Poirier O, Raoux S, Chapman N, Colman S, Leguennec S, MacMahon S, Neal B, Ohkubo T, Woodward M (2003) The ACE gene I/D polymorphism is not associated with the blood pressure and cardiovascular benefits of ACE inhibition. Hypertension 42:297–303. doi:10.1161/01.HYP.0000088322.85804.96 PubMedCrossRef

Hennes MM, O’Shaughnessy IM, Kelly TM, LaBelle P, Egan BM, Kissebah AH (1996) Insulin-resistant lipolysis in abdominally obese hypertensive individuals. Role of the renin-angiotensin system. Hypertension 28:120–126PubMed

Jackson AS, Pollock ML, Ward A (1980) Generalized equations for predicting body density of women. Med Sci Sports Exerc 12:175–182PubMed

Jeng JR, Shieh SM, Harn JJ, Lee MM, Sheu WH, Jeng CY (1997) Angiotensin I converting enzyme gene polymorphism and insulin resistance in patients with hypertension. J Hypertens 15:963–968. doi:10.1097/00004872-199715090-00006 PubMedCrossRef

Kishi K, Muromoto N, Nakaya Y, Miyata I, Hagi A, Hayashi H, Ebina Y (1998) Bradykinin directly triggers GLUT4 translocation via an insulin-independent pathway. Diabetes 47:550–558. doi:10.2337/diabetes.47.4.550 PubMedCrossRef

Kramer H, Wu X, Kan D, Luke A, Zhu X, Adeyemo A, McKenzie C, Cooper R (2005) Angiotensin-converting enzyme gene polymorphisms and obesity: an examination of three black population. Obes Res 13:823–828. doi:10.1038/oby.2005.94 PubMedCrossRef

Mannami T, Katsuya T, Baba S, Inamoto N, Ishikawa K, Higaki J, Ogihara T, Ogata J (2001) Low potentiality of angiotensin-converting enzyme insertion/Deletion polymorphism as a useful predictive marker for carotid atherogenesis in a large general population of a Japanese city: the Suita study. Stroke 32:1250–1256PubMed

Margaglione M, Cappucci G, d’Addedda M, Colaizzo D, Giuliani N, Vecchione G, Mascolo G, Grandone E, Minno GD (1998) PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis: relation to environmental and genetic determinants. Arterioscler Thromb Vasc Biol 18:562–567PubMed

Matsubara M, Suzuki M, Fujiwara T, Kikuya M, Metoki H, Michimata M, Araki T, Kazama I, Satoh T, Hashimoto J, Hozawa A, Ohkubo T, Tsuji I, Katsuya T, Higaki J, Ogihara T, Satoh H, Imai Y (2002) Angiotensin-converting enzyme I/D polymorphism and hypertension: the Ohasama study. J Hypertens 20:1121–1126. doi:10.1097/00004872-200206000-00023 PubMedCrossRef

Matsuzawa Y, Shimomura I, Nakamura T, Keno Y, Tokunaga K (1995) Pathophysiology and pathogenesis of visceral fat obesity. Ann NY Acad Sci 748:399–406PubMedCrossRef

Matthew DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and ß-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419. doi:10.1007/BF00280883 CrossRef

Mondry A, Loh M, Liu P, Zhu A-L, Nagel M (2005) Polymorphisms of the insertion/deletion ACE and M235T AGT genes and hypertension: surprising new findings and meta-analysis of data. BMC Nephrol 6:1–11. doi:10.1186/1471-2369-6-1 PubMedCrossRef

Montgomery HE, Clarkson P, Dollery CM, Prasad K, Losi MA, Hemingway H, Staters D, Jubb M, Gurvain M, Varnava A, World M, Deanfield J, Talmud P, McEwan JR, McKenna WJ, Humphries S (1997) Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training. Circulation 96:741–747PubMed

Nagi DK, Foy CA, Mohamed-Ali V, Yudkin JS, Grant PJ, Knowler WC (1998) Angiotensin-I-converting enzyme (ACE) gene polymorphism, plasma ACE concentrations, and their association with the metabolic syndrome and electrocardiographic coronary artery disease in Pima Indians. Metabolism 47:622–626. doi:10.1016/S0026-0495(98)90250-5 PubMedCrossRef

Panahloo A, Andres C, Mohamed-Ali V, Gould MM, Talmud P, Humphries SE, Yudkin JS (1995) The insertion allele of the ACE gene I/D polymorphism: a candidate gene for insulin resistance? Circulation 92:3390–3393PubMed

Perticone F, Ceravolo R, Maio R, Ventura G, Zingone A, Perrotti N, Mattioli PL (1998) Angiotensin-converting enzyme gene polymorphism is associated with endothelium-dependent vasodilation in never-treated hypertensive patients. Hypertension 31:900–905PubMed

Perticone F, Ceravolo R, Iacopino S, Cloro C, Ventura G, Maio R, Gulletta E, Perrotti N, Mattioli PL (2001) Relationship between angiotensin-converting enzyme gene polymorphism and insulin resistance in never-treated hypertensive patients. J Clin Endocrinol Metab 86:172–178. doi:10.1210/jc.86.1.172 PubMedCrossRef

Rigat B, Hubert C, Alhens-Gelas F, Cambien F, Corvol P, Soubrier F (1990) An insertion/deletion polymorphism in the angiotensin I converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86:1343–1346. doi:10.1172/JCI114844 PubMedCrossRef

Ryan AS, Nicklas BJ, Berman DM, Ferrell RE (2001) The insertion/deletion polymorphism of the ACE gene is related to insulin sensitivity in overweight women. Diabetes Care 24:1646–1652. doi:10.2337/diacare.24.9.1646 PubMedCrossRef

Safar ME, Lajemi M, Rudnichi A, Asmar R, Benetos A (2004) Angiotensin-converting enzyme D/I gene polymorphism and age-related changes in pulse pressures in subjects with hypertension. Arterioscler Thromb Vasc Biol 24:782–786. doi:10.1161/01.ATV.0000119354.41615.33 PubMedCrossRef

Samani NJ, Thompson JR, O’Toole L, Channer K, Woods KL (1996) A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction. Circulation 94:708–712PubMed

Siri WE (1961) Body composition from fluid spaces and density: analysis of methods. In: Brozek J, Henschel A (eds) Techniques for measuring body composition. National Academy of Sciences National Research Council, Washington DC, pp 223–244

Staessen JA, Wang JG, Ginocchio G, Petrov V, Saavedra AP, Soubrier F, Vlietinck R, Fagard R (1997) The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk. J Hypertens 15:1579–1592. doi:10.1097/00004872-199715120-00059 PubMedCrossRef

Strazzullo P, Iacone R, Iacoviello L, Russo O, Barba G, Russo P, D’Orazio A, Barbato A, Cappuccio FP, Farinao E, Siani A (2003) Genetic variation in the renin-angiotensin system and abdominal adiposity in men: the Olivetti prospective heart study. Ann Intern Med 138:17–24PubMed

Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A (1998) Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 97:2222–2229PubMed

Thomas GN, Tomlinson B, Chan JC, Sanderson JE, Cockram CS, Critchley JA (2001) Renin-angiotensin system gene polymorphisms, blood pressure, dyslipidemia, and diabetes in Hong Kong Chinese: a significant association of the ACE insertion/deletion polymorphism with type 2 diabetes. Diabetes Care 24:356–361. doi:10.2337/diacare.24.2.356 PubMedCrossRef

Uemura K, Nakura J, Kohara K, Miki T (2000) Association of ACE I/D polymorphism with cardiovascular risk factors. Hum Genet 107:239–242. doi:10.1007/s004390000358 PubMedCrossRef

Um JY, Mun KS, An NH, Kim PG, Kim SD, Song YS, Lee KN, Lee KM, Wi DH, You YO, Kim HM (2003) Polymorphism of angiotensin-converting enzyme gene and BMI in obese Korean women. Clin Chim Acta 328:173–178. doi:10.1016/S0009-8981(02)00428-X PubMedCrossRef

Wang J-G, He X, Wang G-L, Li Y, Zhou H-F, Zhang W-Z, Zhan Y-M, Zhu D-L (2004) Family-based associations between the angiotensin-converting enzyme insertion/deletion polymorphism and multiple cardiovascular risk factors in Chinese. J Hypertens 22:487–491. doi:10.1097/00004872-200403000-00010 PubMedCrossRef

WHO (1999) Report of a WHO consultation on obesity: preventing and managing. In the global epidemic, Geneva

Title: Association of angiotensin-converting enzyme insertion/deletion polymorphism with obesity, cardiovascular risk factors and exercise-mediated changes in Korean women
Author: Kijin Kim
Publication date: 01-04-2009
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 6/2009
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-008-0973-6

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Association of angiotensin-converting enzyme insertion/deletion polymorphism with obesity, cardiovascular risk factors and exercise-mediated changes in Korean women

Abstract

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