Top

Published in:

01-12-2005 | Short Communication

Iron-regulatory protein hepcidin is increased in female athletes after a marathon

Authors: L. Roecker, R. Meier-Buttermilch, L. Brechtel, E. Nemeth, T. Ganz

Published in: European Journal of Applied Physiology | Issue 5-6/2005

Abstract

The propose of this study was to determine the influence of marathon race on hepcidin excretion in female athletes (age 26–45 years). Urine samples were taken before, immediately after, 1 and 3 days after the race. In the average, hepcidin transiently increased at day 1 from 32 to 85 ng/mg creatinine. We propose that the frequently observed iron deficiency of females runners is caused by elevated hepcidin levels.

Abarbanel J, Benet AE, Lask D, Kimche D (1990) Sports hematuria. J Urol 143:887–890PubMed

Brownlie T, Untermohlen V, Hinton PS, Haas JD (2004) Tissue iron deficiency without anemia impairs adaption in endurance capacity after aerobic training in previously untrained women. Am J Clin Nutr 79:437–443PubMed

Ganz T (2005) Hepcidin—a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol 18:171–182PubMedCrossRef

Magnusson B, Hallberg L, Rossander L, Swolin B (1984) Iron Metabolism and ‘Sports Anemia’. II A Hematological comparison of elite runners and control subjects. Acta Med Scand 216:157–164PubMedCrossRef

Mattusch F, Dufaux B, Heine O, Mertens I, Rost R (2000) Reduction of the plasma concentration of c-reactive protein following nine month of endurance training. Int J Sports Med 21:21–24PubMedCrossRef

Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T (2003) Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101:2461–2463PubMedCrossRef

Nemeth E, Rivera S, Gabayan V, Keller CH, Taudorf S, Pedersen BK, Ganz T (2004) IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113:1271–1276PubMedCrossRef

Northoff H, Berg A (1991) Immunologie mediators as parameters of the reaction to strenuous exercise. Int J Sports Med 12:9–15CrossRef

Pedersen BK, Hoffmann-Gortz L (2000) Exercise and the immune system: regulation, integration and adaptation. Physiol Rev 80:1055–1081PubMed

Roecker L, Hinz K, Holland K, Gunga H-CH, Vogelgesang J, Kiesewetter H (2002) Influence of endurance exercise (triathlon) on circulating transferrin receptors and other indicators of iron status in female athletes. Clin Lab 48:307–312

Schumacher YO, Schmid A, Grathwohl D, Bultermann D, Berg A (2002) Hematological indices and iron status in athletes of various sports and performances. Med Sci Sports Exerc 34:869–875PubMedCrossRef

Shaskey J, Green GA (2000) Sports heamatology. Sports Med 29:27–38PubMedCrossRef

Stewart JG, Ahlquist DA, McGill DB, Ilstrup DM, Schwartz S, Owen RA (1984) Gastrointestinal blood loss and anemia in runners. Ann Intern Med 100:843–845PubMed

Weight LM, Byrne MJ, Jacobs P (1991) Haemolytic effects of exercise. Clin Sci 81:147–152PubMed

Title: Iron-regulatory protein hepcidin is increased in female athletes after a marathon
Authors: L. Roecker
R. Meier-Buttermilch
L. Brechtel
E. Nemeth
T. Ganz
Publication date: 01-12-2005
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 5-6/2005
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-005-0055-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Iron-regulatory protein hepcidin is increased in female athletes after a marathon

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 5-6/2005

The effects of 24 weeks of moderate- or high-intensity exercise on insulin resistance

The effects of carbohydrate supplementation during the second of two prolonged cycling bouts on immunoendocrine responses

Resistance and functional training reduces knee extensor position fluctuations in functionally limited older adults

Determining localized garment insulation values from manikin studies: computational method and results

l-Carnitine and the recovery from exhaustive endurance exercise: a randomised, double-blind, placebo-controlled trial

Effects of eccentric exercise-induced muscle injury on blood levels of platelet activating factor (PAF) and other inflammatory markers