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01-10-2004 | Original Article

Cardiac output and oxygen release during very high-intensity exercise performed until exhaustion

Authors: Ruddy Richard, Evelyne Lonsdorfer-Wolf, Stéphane Dufour, Stéphane Doutreleau, Monique Oswald-Mammosser, Véronique L. Billat, Jean Lonsdorfer

Published in: European Journal of Applied Physiology | Issue 1-2/2004

Abstract

Our objectives were firstly, to study the patterns of the cardiac output (Q̇) and the arteriovenous oxygen difference [(a−v̄)O₂] responses to oxygen uptake (V̇O₂) during constant workload exercise (CWE) performed above the respiratory compensation point (RCP), and secondly, to establish the relationships between their kinetics and the time to exhaustion. Nine subjects performed two tests: a maximal incremental exercise test (IET) to determine the maximal V̇O₂ ( V̇ O₂peak), and a CWE test to exhaustion, performed at p Δ50 (intermediate power between RCP and V̇O₂peak). During CWE, V̇ O₂ was measured breath-by-breath, Q̇ was measured beat-by-beat with an impedance device, and blood lactate (LA) was sampled each minute. To calculate ( a−v̄ )O₂, the values of V̇ O₂ and Q̇ were synchronised over 10 s intervals. A fitting method was used to describe the V̇ O₂, Q̇ and ( a−v̄ )O₂ kinetics. The ( a−v̄ )O₂ difference followed a rapid monoexponential function, whereas both V̇ O₂ and Q̇ were best fitted by a single exponential plus linear increase: the time constant (τ) V̇ O₂ [57 (20 s)] was similar to τ ( a−v̄ )O₂, whereas τ for Q̇ was significantly higher [89 (34) s, P <0.05] (values expressed as the mean and standard error). LA started to increase after 2 min CWE then increased rapidly, reaching a similar maximal value as that seen during the IET. During CWE, the rapid component of V̇O₂ uptake was determined by a rapid and maximal ( a−v̄)O₂ extraction coupled with a two-fold longer Q̇ increase. It is likely that lactic acidosis markedly increased oxygen availability, which when associated with the slow linear increase of Q̇ , may account for the V̇ O₂ slow component. Time to exhaustion was larger in individuals with shorter time delay for ( a−v̄ )O₂ and a greater τ for Q̇.

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Title: Cardiac output and oxygen release during very high-intensity exercise performed until exhaustion
Authors: Ruddy Richard
Evelyne Lonsdorfer-Wolf
Stéphane Dufour
Stéphane Doutreleau
Monique Oswald-Mammosser
Véronique L. Billat
Jean Lonsdorfer
Publication date: 01-10-2004
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 1-2/2004
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-004-1149-7

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Cardiac output and oxygen release during very high-intensity exercise performed until exhaustion

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