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International Archives of Occupational and Environmental Health

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01-02-2014 | Original Article

Accidental exposure to polychlorinated biphenyls (PCB) in waste cargo after heavy seas. Global waste transport as a source of PCB exposure

Authors: Lygia Therese Budnik, Ralf Wegner, Ulrich Rogall, Xaver Baur

Published in: International Archives of Occupational and Environmental Health | Issue 2/2014

Abstract

Objectives

After cargo with PCB-containing transformer oil waste was damaged in heavy seas, the vessel crew exposed to PCB developed itching and acne-form eruption of the skin. The objective of our study was to analyse this work-related incident and its effects on health.

Methods

Air and wipe test samples were taken in the ship for analysis of PCB (28/52/101/138/153/180); clinical investigations of all seafarers (n = 6) included lung function, chest X-ray, clinical chemistry and biomonitoring (plasma PCBs, chlorophenols in urine) measured after a latency of 7 weeks. The biomonitoring data were adjusted according to age-related reference values and validated against controls (n = 96).

Results

Biomonitoring showed elevated PCB-28-/52/-102/-138 congeners (mean 1.16/0.91/136, ∑PCB: 5.82 μg/l), which correlates with the dust samples from the cargo hold (∑PCB. 9,440 mg/m²) and with 6.1 and 5.0 μg/m³ in stern and bow cargo air samples. IgE elevation in two seafarers and substantial blood sedimentation rate increase with anaemia or pulmonary emphysema were unlikely to be caused by PCB exposure. Although two members showed slightly elevated airway resistance values, other lung function parameters were normal and reactive airways dysfunction syndrome due to PCBs could be excluded. Elevated chlorophenols in urine could contribute to the manifestation of chloracne.

Conclusions

PCB-52/-101/-138 found in plasma and in air samples confirm exposure to PCB. Acne-form skin eruptions were from occupational exposure to polychlorinated biphenyls in the spilt transformer oil. There were no other abnormal findings in medical and clinical examinations that could be attributed to PCBs. This does not exclude possible long-term effects.

Adams ET, Auerbach S, Blackshear PE, Bradley A, Gruebbel MM, Little PB, Malarkey D, Maronpot R, McKay JS, Miller RA, Moore RR, Morrison JP, Nyska A, Ramot Y, Rao D, Suttie A, Wells MY, Willson GA, Elmore SA (2011) Proceedings of the 2010 national toxicology program satellite symposium. Toxicol Pathol 39(1):240–266CrossRef

Altenkirch H, Stoltenburg G, Haller D, Hopmann D, Walter G (1996) Clinical data on three cases of occupationally induced PCB-intoxication. Neurotoxicology 17(3–4):639–643

Badia-Vila M, Ociepa M, Mateo R, Guitart R (2000) Comparison of residue levels of persistent organochlorine compounds in butter from Spain and from other European countries. J Environ Sci Health B 35(2):201–210CrossRef

Bent S, Rachor-Ebbinghaus R, Schmidt C (2000) Decontamination of highly polychlorinated biphenyl contaminated indoor areas by complete removal of primary and secondary sources. Gesundheitswesen 62(2):86–92CrossRef

Breivik K, Gioia R, Chakraborty P, Zhang G, Jones KC (2011) Are reductions in industrial organic contaminants emissions in rich countries achieved partly by export of toxic wastes? Environ Sci Technol 45(21):9154–9160CrossRef

Brouwer A, Longnecker MP, Birnbaum LS, Cogliano J, Kostyniak P, Moore J, Schantz S, Winneke G (1999) Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs. Environ Health Perspect 107(Suppl 4):639–649CrossRef

Burgin DE, Diliberto JJ, Derr-Yellin EC, Kannan N, Kodavanti PR, Birnbaum LS (2001) Differential effects of two lots of Aroclor 1254 on enzyme induction, thyroid hormones, and oxidative stress. Environ Health Perspect 109(11):1163–1168CrossRef

Cheng WN, Coenraads PJ, Hao ZH, Liu GF (1993) A health survey of workers in the pentachlorophenol section of a chemical manufacturing plant. Am J Ind Med 24(1):81–92CrossRef

Coenraads PJ, Olie K, Tang NJ (1999) Blood lipid concentrations of dioxins and dibenzofurans causing chloracne. Br J Dermatol 141(4):694–697CrossRef

Consonni D, Sindaco R, Bertazzi PA (2012) Blood levels of dioxins, furans, dioxin-like PCBs, and TEQs in general populations: a review, 1989–2010. Environ Int. doi:10.1016/j.envint.2012.01.004

Crinnion WJ (2011) Polychlorinated biphenyls: persistent pollutants with immunological, neurological, and endocrinological consequences. Altern Med Rev 16(1):5–13

Deutch B, Hansen JC (1999) High blood levels of persistent organic pollutants are statistically correlated with smoking. Int J Circumpolar Health 58(3):214–219

DFG (2012) Analytical methods from the working group on analytical chemistry, AibM, DFG German Research Council (MAK commission) publications. http://onlinelibrarywileycom/book/101002/3527600418/topics

Diamond ML, Melymuk L, Csiszar SA, Robson M (2010) Estimation of PCB stocks, emissions, and urban fate: will our policies reduce concentrations and exposure? Environ Sci Technol 44(8):2777–2783. doi:10.1021/es9012036 CrossRef

Fitzgerald EF, Deres DA, Hwang SA, Bush B, Yang BZ, Tarbell A, Jacobs A (1999) Local fish consumption and serum PCB concentrations among Mohawk men at Akwesasne. Environ Res 80(2 Pt 2):S97–S103CrossRef

Gabrio T, Piechotowski I, Wallenhorst T, Klett M, Cott L, Friebel P, Link B, Schwenk M (2000) PCB-blood levels in teachers, working in PCB-contaminated schools. Chemosphere 40(9–11):1055–1062CrossRef

Garner CE, Jefferson WN, Burka LT, Matthews HB, Newbold RR (1999) In vitro estrogenicity of the catechol metabolites of selected polychlorinated biphenyls. Toxicol Appl Pharmacol 154(2):188–197CrossRef

Guo YL, Yu ML, Hsu CC, Rogan WJ (1999) Chloracne, goiter, arthritis, and anemia after polychlorinated biphenyl poisoning: 14-year follow-Up of the Taiwan Yucheng cohort. Environ Health Perspect 107(9):715–719CrossRef

Hany J, Lilienthal H, Sarasin A, Roth-Harer A, Fastabend A, Dunemann L, Lichtensteiger W, Winneke G (1999) Developmental exposure of rats to a reconstituted PCB mixture or aroclor 1254: effects on organ weights, aromatase activity, sex hormone levels, and sweet preference behaviour. Toxicol Appl Pharmacol 158(3):231–243CrossRef

Hartwig A (2012) The MAK-collection for occupational health and safety. Villey-VCH http://onlinelibrarywileycom/book/101002/3527600418/topics

Herrick RF, Meeker JD, Hauser R, Altshul L, Weymouth GA (2007) Serum PCB levels and congener profiles among US construction workers. Environ Health 6:25CrossRef

Hirota Y, Hirohata T, Kataoka K, Shinohara S, Tokiwa H (1993) Laboratory findings in the medical examination of chronic “Yusho” (PCB poisoning) patients with special reference to blood PCB and serum triglyceride. Fukuoka Igaku Zasshi 84:287–293

Hoffmann W (1996) Organochlorine compounds: risk of Non-Hodgkin’s lymphoma and breast cancer? Arch Environ Health 51:189–192CrossRef

Hsieh SF, Yen YY, Lan SJ, Hsieh CC, Lee CH, Ko YC (1996) A cohort study on mortality and exposure to polychlorinated biphenyls. Arch Environ Health 51(6):417–424CrossRef

Kodavanti PR, Kannan N, Yamashita N, Derr-Yellin EC, Ward TR, Burgin DE, Tilson HA, Birnbaum LS (2001) Differential effects of two lots of aroclor 1254: congener-specific analysis and neurochemical end points. Environ Health Perspect 109(11):1153–1161CrossRef

Lawton RW, Ross MR, Feingold J (1986) Spirometric findings in capacitor workers occupationally exposed to polychlorinated biphenyls (PCBs). J Occup Med 28(6):453–456CrossRef

Lazaro R, Herrera A, Conchello MP, Arino AA, Bayarri S, Yague C, Peiro JM (1999) Levels of selected polychlorinated biphenyl congeners in total diet samples from Aragon, Spain. J Food Prot 62(9):1054–1058

Leijs MM, Koppe JG, Olie K, van Aalderen WM, de Voogt P, ten Tusscher GW (2009) Effects of dioxins, PCBs, and PBDEs on immunology and hematology in adolescents. Environ Sci Technol 43(20):7946–7951. doi:10.1021/es901480f CrossRef

Lemesh RA (1992) Polychlorinated biphenyls: an overview of metabolic toxicologic and health consequences. Vet Hum Toxicol 34(3):256–260

Maroni M, Colombi A, Arbosti G, Cantoni S, Foa V (1981) Occupational exposure to polychlorinated biphenyls in electrical workers. II. Health effects. Br J Ind Med 38(1):55–60

Masuda Y (2001) Fate of PCDF/PCB congeners and change of clinical symptoms in patients with Yusho PCB poisoning for 30 years. Chemosphere 43(4–7):925–930CrossRef

Nakanishi Y, Nomoto Y, Matsuki A, Kunitake R, Hara N (1995) Effect of polychlorinated biphenyls and polychlorinated dibenzofurans on leukocyte in peripheral blood and bronchoalveolar lavage fluid. Fukuoka Igaku Zasshi 86(5):261–266

NIOSH C (2006) Exposure to Polychlorinated Biphenyls and the Risk of Disease. http://wwwcdcgov/niosh/pgms/worknotify/PCB2html

Onozuka D, Yoshimura T, Kaneko S, Furue M (2009) Mortality after exposure to polychlorinated biphenyls and polychlorinated dibenzofurans: a 40-year follow-up study of Yusho patients. Am J Epidemiol 169(1):86–95CrossRef

Prince MM, Ruder AM, Hein MJ, Waters MA, Whelan EA, Nilsen N, Ward EM, Schnorr TM, Laber PA, Davis-King KE (2006) Mortality and exposure response among 14,458 electrical capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs). Environ Health Perspect 114(10):1508–1514CrossRef

Quanjer PH, Stanojevic S, Cole TJ, Baur X, Hall GL, Culver B, Enright PL, Hankinson JL, Ip MS, Zheng J, Stocks J (2012) Multi-ethnic reference values for spirometry for the 3–95 year age range: the global lung function 2012 equations. Eur Respir J. doi:10.1183/09031936.00080312

Rallis GN, Sakkas VA, Boumba VA, Vougiouklakis T, Albanis TA (2012) Determination of organochlorine pesticides and polychlorinated biphenyls in post-mortem human lung by matrix solid-phase dispersion with the aid of response surface methodology and desirability function. J Chromatogr A 1227:1–9CrossRef

Recio-Vega R, Mendez-Henandez A, Gabriel AP, Jacobo-Avila A, Portales-Castanedo A, Hernandez-Gonzalez S, Gallegos-Arreola MP, Ocampo-Gomez G (2012) Potentially estrogenic polychlorinated biphenyls congeners serum levels and its relation with lung cancer. J Appl Toxicol. doi:10.1002/jat.2763]

Reggiani G, Bruppacher R (1985) Symptoms, signs and findings in humans exposed to PCBs and their derivatives. Environ Health Perspect 60:225–232CrossRef

Robson M, Melymuk L, Csiszar SA, Giang A, Diamond ML, Helm PA (2010) Continuing sources of PCBs: the significance of building sealants. Environ Int 36(6):506–513CrossRef

Ruder AM, Hein MJ, Nilsen N, Waters MA, Laber P, Davis-King K, Prince MM, Whelan E (2006) Mortality among workers exposed to polychlorinated biphenyls (PCBs) in an electrical capacitor manufacturing plant in Indiana: an update. Environ Health Perspect 114(1):18–23CrossRef

Rushneck DR, Beliveau A, Fowler B, Hamilton C, Hoover D, Kaye K, Berg M, Smith T, Telliard WA, Roman H, Ruder E, Ryan L (2004) Concentrations of dioxin-like PCB congeners in unweathered Aroclors by HRGC/HRMS using EPA Method 1668A. Chemosphere 54(1):79–87CrossRef

Sala M, Sunyer J, Otero R, Santiago-Silva M, Camps C, Grimalt J (1999) Organochlorine in the serum of inhabitants living near an electrochemical factory. Occup Environ Med 56(3):152–158CrossRef

Schettgen T, Alt A, Preim D, Keller D, Kraus T (2012a) Biological monitoring of indoor-exposure to dioxin-like and non-dioxin-like polychlorinated biphenyls (PCB) in a public building. Toxicol Lett 213(1):116–121CrossRef

Schettgen T, Gube M, Esser A, Alt A, Kraus T (2012b) Plasma polychlorinated biphenyls (PCB) levels of workers in a transformer recycling company, their family members, and employees of surrounding companies. J Toxicol Environ Health A 75(8–10):414–422CrossRef

Selden AI, Lundholm C, Johansson N, Wingfors H (2008) Polychlorinated biphenyls (PCB), thyroid hormones and cytokines in construction workers removing old elastic sealants. Int Arch Occup Environ Health 82(1):99–106CrossRef

Smith AB, Schloemer J, Lowry LK, Smallwood AW, Ligo RN, Tanaka S, Stringer W, Jones M, Hervin R, Glueck CJ (1982) Metabolic and health consequences of occupational exposure to polychlorinated biphenyls. Br J Ind Med 39(4):361–369

Smits JE, Fernie KJ, Bortolotti GR, Marchant TA (2002) Thyroid hormone suppression and cell-mediated immunomodulation in American kestrels (Falco sparverius) exposed to PCBs. Arch Environ Contam Toxicol 43(3):338–344CrossRef

Tokunaga S, Hirota Y, Kataoka K (1999) Association between the results of blood test and blood PCB level of chronic Yusho patients twenty five years after the outbreak. Fukuoka Igaku Zasshi 90(5):157–161

Tsuji H, Hirahashi T, Ogata H, Fujishima M (1999) Serum immunoglobulin concentrations and autoantibodies in patients with Yusho. Fukuoka Igaku Zasshi 90(5):147–149

UBA (2007) Health evaluation of dioxin-like polychlorinated bisphenols in indoor air. German Joint Working Group on Indoor Guidelines of the Federal Environment Agency, Department of Health; http://wwwumweltbundesamtde/gesundheit/innenraumhygiene/ dioxinaehnliche_polychlorierte_biphenylepdf

UBA (2012) Referenzvalues for organochlride substances, polychlorinated bisphenyls, chlorophenols (UBA, German Environmental Protection Ageny) http://wwwubade/gesundheit/publikationen/indexhtml/khb

Weisglas-Kuperus N, Vreugdenhil HJ, Mulder PG (2004) Immunological effects of environmental exposure to polychlorinated biphenyls and dioxins in Dutch school children. Toxicol Lett 149(1–3):281–285CrossRef

G-Equas. External quality assessment scheme and certification for occupational-medical and environmental-medical toxicological analyses in biological materials. www.g-equas.de/

Zhang W, Sargis RM, Volden PA, Carmean CM, Sun XJ, Brady MJ (2012) PCB 126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl hydrocarbon receptor. PLoS ONE 5(7):e37103CrossRef

Title: Accidental exposure to polychlorinated biphenyls (PCB) in waste cargo after heavy seas. Global waste transport as a source of PCB exposure
Authors: Lygia Therese Budnik
Ralf Wegner
Ulrich Rogall
Xaver Baur
Publication date: 01-02-2014
Publisher: Springer Berlin Heidelberg
Published in: International Archives of Occupational and Environmental Health / Issue 2/2014
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-012-0841-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Accidental exposure to polychlorinated biphenyls (PCB) in waste cargo after heavy seas. Global waste transport as a source of PCB exposure

Abstract

Objectives

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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