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International Archives of Occupational and Environmental Health

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01-01-2013 | Original Article

Exposure of healthy subjects with emissions from a gas metal arc welding process: part 3—biological effect markers and lung function

Authors: P. Brand, K. Bischof, L. Siry, J. Bertram, T. Schettgen, U. Reisgen, T. Kraus, M. Gube

Published in: International Archives of Occupational and Environmental Health | Issue 1/2013

Abstract

Background

Metal active gas welding (MAG) is a widely-used welding technique resulting in high emissions of welding fume particles. This study investigated whether short-term exposure to these fume particles results in changes in lung function and early stages of inflammatory reactions.

Methods

Twelve healthy, young male subjects were exposed to MAG fumes for 6 h with three different exposure concentrations in a three-fold cross-over study design. Exposure was performed in the “Aachen Workplace Simulation Laboratory” under controlled conditions with constant fume concentration. Fume concentrations were 0, 1, and 2.5 mg m⁻³ in randomized order. Before and after each exposure, spirometry, and impulse oscillometry were performed and breath condensate samples were collected in order to quantify inflammatory markers like Nitrate, Nitrite, Nitrotyrosine, Hydroxyprolin and Malondialdehyde.

Results

A significant dependency on the exposure concentration could not be established for any of the endpoint parameters.

Conclusion

In healthy, young subjects neither changes in spirometry nor changes in inflammatory markers measured in exhaled breath condensate could be detected after short-term exposure.

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Title: Exposure of healthy subjects with emissions from a gas metal arc welding process: part 3—biological effect markers and lung function
Authors: P. Brand
K. Bischof
L. Siry
J. Bertram
T. Schettgen
U. Reisgen
T. Kraus
M. Gube
Publication date: 01-01-2013
Publisher: Springer-Verlag
Published in: International Archives of Occupational and Environmental Health / Issue 1/2013
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-012-0740-1

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Springer Medicine

Exposure of healthy subjects with emissions from a gas metal arc welding process: part 3—biological effect markers and lung function

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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