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Published in: International Archives of Occupational and Environmental Health 6/2011

01-08-2011 | Original Article

Occupational exposure levels to benzene in Italy: findings from a national database

Authors: Alberto Scarselli, Alessandra Binazzi, Davide Di Marzio

Published in: International Archives of Occupational and Environmental Health | Issue 6/2011

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Abstract

Purpose

Benzene is classified as human carcinogen and the association with lymphohaematopoietic cancer has been observed in many occupational epidemiological studies. The aim of this study is to summarize data about occupational exposure levels to benzene in Italy.

Methods

Airborne concentrations of benzene were selected from the Italian database on occupational exposure to carcinogens in the period 1996–2007. Descriptive statistics were calculated for exposure-related variables. The number of workers potentially exposed was estimated for the industrial sectors better characterized in the database. An analysis through linear mixed model was performed to determine factors affecting the exposure level.

Results

The total number of benzene exposure measurements was 15,776, with an overall arithmetic mean of 0.09 ppm and a geometric mean of 0.02 ppm. Economic sectors with a higher number of measurements (N) were the manufacturing of chemicals (N = 10,480) and the petrochemical industry (N = 2,652). The number of workers potentially exposed in the selected sectors was 37,137, and the most predictive independent variables of the exposure level were measurement year and job category.

Conclusions

Occupational benzene exposure is still widespread in many different industries, and proactive measures are needed to reduce its impact on the workers’ health. The potential of occupational exposure databases as a source of data for exposure assessment is confirmed.
Literature
go back to reference ACGIH (2007) TLVs® and BEIs®. Threshold limit values for chemical substances and physical agents and biological exposure indices. American Conference of Governmental Industrial Hygienists (ACGIH) Worldwide, Cincinnati, OH ACGIH (2007) TLVs® and BEIs®. Threshold limit values for chemical substances and physical agents and biological exposure indices. American Conference of Governmental Industrial Hygienists (ACGIH) Worldwide, Cincinnati, OH
go back to reference ATSDR (1995) Toxicological profile for benzene (Update). Agency for toxic substances and disease registry (ATSDR). Atlanta, GA ATSDR (1995) Toxicological profile for benzene (Update). Agency for toxic substances and disease registry (ATSDR). Atlanta, GA
go back to reference Bernardini P, Giannandrea F, Voso MT, Sica S (2005) Myeloproliferative disorders due to the use of gasoline as a solvent: report of three cases. Med Lav 96:119–125 [in Italian] Bernardini P, Giannandrea F, Voso MT, Sica S (2005) Myeloproliferative disorders due to the use of gasoline as a solvent: report of three cases. Med Lav 96:119–125 [in Italian]
go back to reference Bloemen LJ, Youk A, Bradley TD, Bodner KM, Marsh G (2004) Lymphohaematopoietic cancer risk among chemical workers exposed to benzene. Occup Environ Med 61:270–274 Bloemen LJ, Youk A, Bradley TD, Bodner KM, Marsh G (2004) Lymphohaematopoietic cancer risk among chemical workers exposed to benzene. Occup Environ Med 61:270–274
go back to reference Capleton AC, Levy LS (2005) An Overview of occupational benzene exposures and occupational exposure limits in Europe and North America. Chem Biol Interact 153–154:43–53CrossRef Capleton AC, Levy LS (2005) An Overview of occupational benzene exposures and occupational exposure limits in Europe and North America. Chem Biol Interact 153–154:43–53CrossRef
go back to reference Collins JJ, Ireland B, Buckley CF, Shepperly D (2003) Lymphohaematopoeitic cancer mortality among workers with benzene exposure. Occup Environ Med 60:676–679 Collins JJ, Ireland B, Buckley CF, Shepperly D (2003) Lymphohaematopoeitic cancer mortality among workers with benzene exposure. Occup Environ Med 60:676–679
go back to reference Coulon F, Orsi R, Turner C, Walton C, Daly P, Pollard SJ (2009) Understanding the fate and transport of petroleum hydrocarbons from coal tar within gasholders. Environ Int 35:248–252CrossRef Coulon F, Orsi R, Turner C, Walton C, Daly P, Pollard SJ (2009) Understanding the fate and transport of petroleum hydrocarbons from coal tar within gasholders. Environ Int 35:248–252CrossRef
go back to reference Davis ME, Blicharz AP, Hart JE, Laden F, Garshick E, Smith TJ (2007) Occupational exposure to volatile organic compounds and aldehydes in the US trucking industry. Environ Sci Technol 41:7152–7158CrossRef Davis ME, Blicharz AP, Hart JE, Laden F, Garshick E, Smith TJ (2007) Occupational exposure to volatile organic compounds and aldehydes in the US trucking industry. Environ Sci Technol 41:7152–7158CrossRef
go back to reference EPA (1981) Hazardous wastes from specific sources. Identification and listing of hazardous waste. Environmental Protection Agency (EPA) US Code of Federal Regulations. 40 CFR 261.32. EPA, US EPA (1981) Hazardous wastes from specific sources. Identification and listing of hazardous waste. Environmental Protection Agency (EPA) US Code of Federal Regulations. 40 CFR 261.32. EPA, US
go back to reference Hinwood AL, Rodriguez C, Runnion T, Farrar D, Murray F, Horton A et al (2007) Risk factors for increased BTEX exposure in four Australian cities. Chemosphere 66:533–541CrossRef Hinwood AL, Rodriguez C, Runnion T, Farrar D, Murray F, Horton A et al (2007) Risk factors for increased BTEX exposure in four Australian cities. Chemosphere 66:533–541CrossRef
go back to reference Hornung R, Reed LD (1990) Estimation of average concentration in the presence of nondetectable values. App Occup Environ Hyg 5:46–51 Hornung R, Reed LD (1990) Estimation of average concentration in the presence of nondetectable values. App Occup Environ Hyg 5:46–51
go back to reference Huff J (2007) Benzene-induced cancers: abridge history and occupational health impact. Int J Occup Environ Health 13:213–221 Huff J (2007) Benzene-induced cancers: abridge history and occupational health impact. Int J Occup Environ Health 13:213–221
go back to reference IARC (1987) Overall evaluations of carcinogenicity: an updating of IARC monographs, vols. 1–42. IARC monographs on the evaluation of carcinogenic risks to humans, Suppl. 7. International Agency for Research on Cancer (IARC), Lyon IARC (1987) Overall evaluations of carcinogenicity: an updating of IARC monographs, vols. 1–42. IARC monographs on the evaluation of carcinogenic risks to humans, Suppl. 7. International Agency for Research on Cancer (IARC), Lyon
go back to reference ISTAT (2004) Eight data census on industry and services, 2001. Italy. National Statistics Institute (ISTAT), Rome [in Italian] ISTAT (2004) Eight data census on industry and services, 2001. Italy. National Statistics Institute (ISTAT), Rome [in Italian]
go back to reference Italian Legislative Decree No 66 of 25 February 2000 (2000) Implementation of directives no. 97/42/EC and n. 1999/38/EC, modifying directive n. 90/394/EEC, concerning on the protection of workers from the risks related to exposure to carcinogens or mutagens at work. Ordinary Suppl Off Gazette 141(70):19–23 [in Italian] Italian Legislative Decree No 66 of 25 February 2000 (2000) Implementation of directives no. 97/42/EC and n. 1999/38/EC, modifying directive n. 90/394/EEC, concerning on the protection of workers from the risks related to exposure to carcinogens or mutagens at work. Ordinary Suppl Off Gazette 141(70):19–23 [in Italian]
go back to reference Lan Q, Zhang L, Li G, Vermeulen R, Weinberg RS, Disemeci M et al (2004) Hematotoxicity in workers exposed to low levels of benzene. Science 306:1774–1776CrossRef Lan Q, Zhang L, Li G, Vermeulen R, Weinberg RS, Disemeci M et al (2004) Hematotoxicity in workers exposed to low levels of benzene. Science 306:1774–1776CrossRef
go back to reference Mirabelli D, Kauppinen T (2005) Occupational exposure to carcinogens in Italy: an update of CAREX database. Int J Occup Environ Health 11:53–63 Mirabelli D, Kauppinen T (2005) Occupational exposure to carcinogens in Italy: an update of CAREX database. Int J Occup Environ Health 11:53–63
go back to reference OSHA (1987) Occupational exposure to benzene: final rule, September 11, Part II, Fed. Reg. 52 34460–34578. Occupational Safety and Health Administration (OSHA), US OSHA (1987) Occupational exposure to benzene: final rule, September 11, Part II, Fed. Reg. 52 34460–34578. Occupational Safety and Health Administration (OSHA), US
go back to reference Panko JM, Gaffney SH, Burns AM, Unice KM, Kreider ML, Booher LE et al (2009) Occupational exposure to benzene at the ExxonMobil refinery at Baton Rouge, Louisiana (1977–2005). J Occup Environ Hyg 6:517–529CrossRef Panko JM, Gaffney SH, Burns AM, Unice KM, Kreider ML, Booher LE et al (2009) Occupational exposure to benzene at the ExxonMobil refinery at Baton Rouge, Louisiana (1977–2005). J Occup Environ Hyg 6:517–529CrossRef
go back to reference Qu Q, Shore R, Li G, Jin X, Chen LC, Cohen B et al (2002) Hematological changes among Chinese workers with a broad range of benzene exposures. Am J Ind Med 42:275–285CrossRef Qu Q, Shore R, Li G, Jin X, Chen LC, Cohen B et al (2002) Hematological changes among Chinese workers with a broad range of benzene exposures. Am J Ind Med 42:275–285CrossRef
go back to reference Roma-Torres J, Teixeira JP, Silva S, Laffon B, Cunha LM, Méndez J, Mayan O (2006) Evaluation of genotoxicity in a group of workers from a petroleum refinery aromatics plant. Mutat Res 604:19–27 Roma-Torres J, Teixeira JP, Silva S, Laffon B, Cunha LM, Méndez J, Mayan O (2006) Evaluation of genotoxicity in a group of workers from a petroleum refinery aromatics plant. Mutat Res 604:19–27
go back to reference Ruchirawat M, Navasumrit P, Settachan D (2010) Exposure to benzene in various susceptible populations: co-exposures to 1,3-butadiene and PAHs and implications for carcinogenic risk. Chem Biol Interact 184:67–76CrossRef Ruchirawat M, Navasumrit P, Settachan D (2010) Exposure to benzene in various susceptible populations: co-exposures to 1,3-butadiene and PAHs and implications for carcinogenic risk. Chem Biol Interact 184:67–76CrossRef
go back to reference Scarselli A, Montaruli C, Marinaccio A (2007) The Italian information system on occupational exposure to carcinogens (SIREP): structure, contents and future perspectives. Ann Occup Hyg 51:471–478CrossRef Scarselli A, Montaruli C, Marinaccio A (2007) The Italian information system on occupational exposure to carcinogens (SIREP): structure, contents and future perspectives. Ann Occup Hyg 51:471–478CrossRef
go back to reference Scarselli A, Binazzi A, Ferrante P, Marinaccio A (2008) Occupational exposure levels to wood dust in Italy, 1996–2006. Occup Environ Med 65:567–574CrossRef Scarselli A, Binazzi A, Ferrante P, Marinaccio A (2008) Occupational exposure levels to wood dust in Italy, 1996–2006. Occup Environ Med 65:567–574CrossRef
go back to reference Smith MT (2010) Advances in understanding benzene health effects and susceptibility. Annu Rev Public Health 31:133–148CrossRef Smith MT (2010) Advances in understanding benzene health effects and susceptibility. Annu Rev Public Health 31:133–148CrossRef
go back to reference Sorahan T, Kinlen LJ, Doll R (2005) Cancer risks in a historical UK cohort of benzene exposed workers. Occup Environ Med 62:231–236 Sorahan T, Kinlen LJ, Doll R (2005) Cancer risks in a historical UK cohort of benzene exposed workers. Occup Environ Med 62:231–236
go back to reference Steinsvåg K, Bråtveit M, Moen B, Austgulen LV, Hollund BE, Haaland IM et al (2008) Expert assessment of exposure to carcinogens in Norway’s offshore petroleum industry. J Expo Sci Environ Epidemiol 18:175–182CrossRef Steinsvåg K, Bråtveit M, Moen B, Austgulen LV, Hollund BE, Haaland IM et al (2008) Expert assessment of exposure to carcinogens in Norway’s offshore petroleum industry. J Expo Sci Environ Epidemiol 18:175–182CrossRef
go back to reference Suwansaksri J, Wiwanitkit V (2000) Urine trans, trans-muconic acid determination for monitoring of benzene exposure in mechanics. Southeast Asian J Trop Med Public Health 31:587–589 Suwansaksri J, Wiwanitkit V (2000) Urine trans, trans-muconic acid determination for monitoring of benzene exposure in mechanics. Southeast Asian J Trop Med Public Health 31:587–589
go back to reference Teschke K, Marion SA, Vaughan TL, Morgan MS, Camp J (1999) Exposure to wood dust in US industries and occupations, 1979 to 1997. Am J Ind Med 35:581–599CrossRef Teschke K, Marion SA, Vaughan TL, Morgan MS, Camp J (1999) Exposure to wood dust in US industries and occupations, 1979 to 1997. Am J Ind Med 35:581–599CrossRef
go back to reference Teschke K, Olshan AF, Daniels JL, De Roos AJ, Parks CG, Schulz M et al (2002) Occupational exposure assessment in case-control studies: opportunities for improvement. Occup Environ Med 59:575–593CrossRef Teschke K, Olshan AF, Daniels JL, De Roos AJ, Parks CG, Schulz M et al (2002) Occupational exposure assessment in case-control studies: opportunities for improvement. Occup Environ Med 59:575–593CrossRef
go back to reference UNI (2005) Workplace atmospheres-Determination of benzene-Method by dynamic adsorption on active carbon, solvent desorption and gas chromatographic analysis. UNI 11090:2005. Italian Organization for Standardization (UNI), Milan [in Italian] UNI (2005) Workplace atmospheres-Determination of benzene-Method by dynamic adsorption on active carbon, solvent desorption and gas chromatographic analysis. UNI 11090:2005. Italian Organization for Standardization (UNI), Milan [in Italian]
go back to reference Vainiotalo S, Ruonakangas A (1999) Tank truck driver exposure to vapors from oxygenated or reformulated gasolines during loading and unloading. Am Ind Hyg Assoc J 60:518–525 Vainiotalo S, Ruonakangas A (1999) Tank truck driver exposure to vapors from oxygenated or reformulated gasolines during loading and unloading. Am Ind Hyg Assoc J 60:518–525
go back to reference Vitali M, Ensabella F, Stella D, Guidotti M (2006) Exposure to organic solvents among handicraft car painters: a pilot study in Italy. Ind Health 44:310–317CrossRef Vitali M, Ensabella F, Stella D, Guidotti M (2006) Exposure to organic solvents among handicraft car painters: a pilot study in Italy. Ind Health 44:310–317CrossRef
go back to reference Weisel CP (2010) Benzene exposure: an overview of monitoring methods and their findings. Chem Biol Interact 184:58–66CrossRef Weisel CP (2010) Benzene exposure: an overview of monitoring methods and their findings. Chem Biol Interact 184:58–66CrossRef
go back to reference Wilbur S, Wohlers D, Paikoff S, Keith LS, Faroon O (2008) ATSDR evaluation of potential for human exposure to benzene. Toxicol Ind Health 24:399–442CrossRef Wilbur S, Wohlers D, Paikoff S, Keith LS, Faroon O (2008) ATSDR evaluation of potential for human exposure to benzene. Toxicol Ind Health 24:399–442CrossRef
go back to reference Williams PR, Panko JM, Unice K, Brown JL, Paustenbach DJ (2008) Occupational exposures associated with petroleum-derived products containing trace levels of benzene. J Occup Environ Hyg 5:565–574CrossRef Williams PR, Panko JM, Unice K, Brown JL, Paustenbach DJ (2008) Occupational exposures associated with petroleum-derived products containing trace levels of benzene. J Occup Environ Hyg 5:565–574CrossRef
go back to reference Zenz C (1978) Benzene—Attempts to establish a lower exposure standard in the United States. Scand J Work Environ Health 4:103–113 Zenz C (1978) Benzene—Attempts to establish a lower exposure standard in the United States. Scand J Work Environ Health 4:103–113
Metadata
Title
Occupational exposure levels to benzene in Italy: findings from a national database
Authors
Alberto Scarselli
Alessandra Binazzi
Davide Di Marzio
Publication date
01-08-2011
Publisher
Springer-Verlag
Published in
International Archives of Occupational and Environmental Health / Issue 6/2011
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI
https://doi.org/10.1007/s00420-011-0616-9

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