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Graefe's Archive for Clinical and Experimental Ophthalmology

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06-06-2023 | Diabetic Retinopathy | Retinal Disorders

Structure–function associations between contrast sensitivity and widefield swept–source optical coherence tomography angiography in diabetic macular edema

Authors: Grace Baldwin, Filippos Vingopoulos, Itika Garg, Jade Y. Moon, Rebecca Zeng, Ying Cui, Raviv Katz, Rongrong Le, Edward S. Lu, Diane N. Sayah, Zakariyya Hassan, Leo A. Kim, Tobias Elze, Deeba Husain, John B. Miller

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2023

Abstract

Purpose

To evaluate the relationship between contrast sensitivity (CS) and widefield swept–source optical coherence tomography angiography (WF SS-OCTA) vascular metrics in diabetic macular edema (DME) was the purpose.

Methods

This prospectively enrolled cross-sectional observational study included 61 eyes of 48 patients that were tested with the quantitative CS function (qCSF) test on the same day as imaging with WF SS-OCTA (PLEX® Elite 9000, Carl Zeiss Meditec) 3 × 3, 6 × 6, and 12 × 12 mm scans. Outcomes included visual acuity (VA) and multiple qCSF metrics. Vascular metrics included vessel density (VD) and vessel skeletonized density (VSD) in the superficial (SCP) and deep capillary plexus (DCP) and whole retina (WR) and foveal avascular zone (FAZ) parameters. Mixed effects multivariable linear regression models controlling for age, lens status, and diabetic retinopathy stage were performed. Standardized beta coefficients were calculated by refitting the standardized data.

Results

SS-OCTA metrics had a significant association with CS and VA. The effect size of OCTA metrics was larger on CS compared to VA. For example, the standardized beta coefficients for VSD and CS at 3 cpd (β_SCP = 0.76, β_DCP = 0.71, β_WR = 0.72, p < 0.001) were larger than those for VA (β_SCP = − 0.55, p < 0.001; β_DCP = − 0.43, p = 0.004; β_WR = − 0.50, p < 0.001). On 6 × 6 mm images, AULCSF, CS at 3 cpd, and CS at 6 cpd were significantly associated with VD and VSD in all three slab types (SCP, DCP, and WR), while VA was not.

Conclusion

Structure–function associations in patients with DME leveraging the qCSF device suggest microvascular changes on WF SS-OCTA are associated with larger changes in contrast sensitivity than VA.

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Title: Structure–function associations between contrast sensitivity and widefield swept–source optical coherence tomography angiography in diabetic macular edema
Authors: Grace Baldwin
Filippos Vingopoulos
Itika Garg
Jade Y. Moon
Rebecca Zeng
Ying Cui
Raviv Katz
Rongrong Le
Edward S. Lu
Diane N. Sayah
Zakariyya Hassan
Leo A. Kim
Tobias Elze
Deeba Husain
John B. Miller
Publication date: 06-06-2023
Publisher: Springer Berlin Heidelberg
Keywords: Diabetic Retinopathy
Diabetic Retinopathy
Edema
Angiography
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2023
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-023-06086-1

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Springer Medicine

Structure–function associations between contrast sensitivity and widefield swept–source optical coherence tomography angiography in diabetic macular edema

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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