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Graefe's Archive for Clinical and Experimental Ophthalmology

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06-07-2022 | Angiography | Cornea

Changes in retinal vessel and retinal layer thickness after cross-linking in keratoconus via swept-source OCT angiography

Authors: Yusuf Ayaz, Olgar Öcal, Çisil Erkan Pota, Ersan Çetinkaya, Muhammet Kazım Erol, Mustafa Ünal

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 12/2022

Abstract

Purpose

To analyze the postoperative foveal avascular zone (FAZ) area, superficial capillary plexus (SCP), deep capillary plexus (DCP) vascular densities (VD), and retinal layers after cross-linking (CXL) for keratoconus treatment.

Methods

Twenty-seven eyes with cross-linking treatment for keratoconus were included in the study. Foveal avascular zone (FAZ) area, SCP VD, DCP VD, and retinal layers were evaluated by using optical coherence tomography angiography (OCTA). OCTA measurements were made at preoperative, first week, and first and sixth months after the surgery. In addition, corneal topography measurements were also made.

Results

Although there was a decrease in corneal thickness in the follow-up of the patients, there was no significant difference in axial length and anterior chamber depth. There was no significant difference in full retinal thickness in the foveal and parafoveal areas. While there was a significant increase in retinal nerve fiber layer (RNFL) thickness in the foveal area (p = 0.032, p = 0.015, p = 0.017; preoperative values compared to first week, first month, and sixth month respectively), there was a decrease in ganglion cell layer (GCL) thickness in the parafoveal area in the postoperative sixth month (p = 0.028). There was no difference in FAZ measurements. In the parafoveal area, a decrease was observed in SCP VD in the sixth-month control (p = 0.019). There was a significant increase in DCP VD in the foveal area (p = 0.008, p = 0.043, p = 0.040). The preoperative mean CDVA (corrected distance visual acuity) was 0.37 ± 0.16 logMAR and postoperative sixth month mean CDVA was 0.39 ± 0.15. There was no significant difference in visual acuity (p = 0.71).

Conclusion

Keratoconus patients successfully treated with CXL had significant changes in retinal layers and vessel density in the superficial and deep retinal plexus.

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Title: Changes in retinal vessel and retinal layer thickness after cross-linking in keratoconus via swept-source OCT angiography
Authors: Yusuf Ayaz
Olgar Öcal
Çisil Erkan Pota
Ersan Çetinkaya
Muhammet Kazım Erol
Mustafa Ünal
Publication date: 06-07-2022
Publisher: Springer Berlin Heidelberg
Keyword: Angiography
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 12/2022
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-022-05749-9

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Changes in retinal vessel and retinal layer thickness after cross-linking in keratoconus via swept-source OCT angiography

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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