Top

Graefe's Archive for Clinical and Experimental Ophthalmology

Published in:

01-12-2019 | Retinal Disorders

Foveal Abnormality associated with epiretinal Tissue of medium reflectivity and Increased blue-light fundus Autofluorescence Signal (FATIAS)

Authors: Roberto dell’Omo, Serena De Turris, Ciro Costagliola, Gianni Virgili, Ricarda G. Schumann, Matteo Cereda, Isabella D’Agostino, Ermanno dell’Omo, Ferdinando Bottoni

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 12/2019

Abstract

Purpose

To describe a distinct vitreomacular interface disorder (VMID) termed Foveal Abnormality associated with epiretinal Tissue of medium reflectivity and Increased blue-light fundus Autofluorescence Signal (FATIAS).

Methods

A case series including forty-seven eyes of 47 patients. The included eyes must present an irregular foveal contour on optical coherence tomography (OCT) and a pathologically increased autofluorescent signal at the fovea on blue-light fundus autofluorescence (B-FAF). Main outcome measures were morphologic characteristics of the lesions, logarithm of minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA), and central foveal thickness (CFT).

Results

The following two types of FATIAS were identified: (1) the step type characterized by an asymmetric contour of the foveal pit and by a tissue of medium reflectivity on the foveal surface and (2) the rail type characterized by a shallow foveal pit and a rail of tissue of medium reflectivity on the foveal surface. The outer retinal bands were continuous in all cases. Both types presented with an area of increased B-FAF signal, usually bilobed in the step type and round and centered on the foveal pit in the rail type. LogMAR BCVA was 0.09 ± 0.1 and 0.1 ± 0.1 (P = 0.91), and CFT was 197.8 ± 9.7 and 202.2 ± 13.2 (P = 0.19) in the step and in the rail group, respectively.

Conclusions

We describe a distinct VMID named FATIAS. Two types of FATIAS may be appreciated with SD-OCT and B-FAF analyses, the step and the rail type. Both are characterized by abnormal foveal contour and autofluorescence signal.

Koizumi H, Spaide RF, Fisher YL, Freund KB, Klancnik JM Jr, Yannuzzi LA (2008) Three-dimensional evaluation of vitreomacular traction and epiretinal membrane using spectral-domain optical coherence tomography. Am J Ophthalmol 145:509–517. https://doi.org/10.1016/j.ajo.2007.10.014 CrossRefPubMed

Sonmez K, Capone A Jr, Trese MT, Williams GA (2008) Vitreomacular traction syndrome: impact of anatomical configuration on anatomical and visual outcomes. Retina 28:1207–1214. https://doi.org/10.1097/IAE.0b013e31817b6b0f CrossRefPubMed

Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P (2013) The international vitreomacular traction study group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology 120:2611–2619. https://doi.org/10.1016/j.ophtha.2013.07.042 CrossRefPubMed

Gattoussi S, Buitendijk GHS, Peto T, Leung I, Schmitz-Valckenberg S, Oishi A, Wolf S, Deák G, Delcourt C, Klaver CCW, Korobelnik JF, European Eye Epidemiology (E3) consortium (2018) The European Eye Epidemiology spectral-domain optical coherence tomography classification of macular diseases for epidemiological studies. Acta Ophthalmol. https://doi.org/10.1111/aos.13883 Accessed 22 Sept 2018CrossRef

Schmitz-Valckenberg S, Holz FG, Bird AC, Spaide RF (2008) Fundus autofluorescence imaging: review and perspectives. Retina 28:385–409. https://doi.org/10.1097/IAE.0b013e318164a907 CrossRefPubMed

von Rukmann A, Fitzke FW, Gregor ZJ (1998) Fundus autofluorescence in patients with macular holes imaged with a laser scanning ophthalmoscope. Br J Ophthalmol 82:346–351CrossRef

Bottoni F, Carmassi L, Cigada M, Moschini S, Bergamini F (2008) Diagnosis of macular pseudoholes and lamellar macular holes: is optical coherence tomography the “gold standard”? Br J Ophthalmol 92:635–639. https://doi.org/10.1136/bjo.2007.127597 CrossRefPubMed

dell’ Omo R, Virgili G, Rizzo S, De Turris S, Coclite G, Giorgio D, dell’ Omo E, Costagliola C (2017) Role of lamellar hole-associated epiretinal proliferation in lamellar macular holes. Am J Ophthalmol 175:16–29. https://doi.org/10.1016/j.ajo.2016.11.007 CrossRef

dell’ Omo R, Vogt D, Schumann RG, De Turris S, Virgili G, Staurenghi G, Cereda M, Costagliola C, Priglinger SG, Bottoni F (2018) The relationship between blue-fundus autofluorescence and optical coherence tomography in eyes with lamellar macular holes. Invest Ophthalmol Vis Sci 59:3079–3087. https://doi.org/10.1167/iovs.18-24379 CrossRef

10.

dell’ Omo R, Cifariello F, dell’ Omo E, De Lena A, Di Iorio R, Filippelli M, Costagliola C (2013) Influence of retinal vessel printings on metamorphopsia and retinal architectural abnormalities in eyes with idiopathic macular epiretinal membrane. Invest Ophthalmol Vis Sci 54:7803–7811. https://doi.org/10.1167/iovs.13-12817 CrossRef

11.

Pang CE, Spaide RF, Freund KB (2014) Epiretinal proliferation seen in association with lamellar macular holes: a distinct clinical entity. Retina 34:1513–1523. https://doi.org/10.1097/IAE.0000000000000163 CrossRefPubMed

12.

Stalmans P, Benz MS, Gandorfer A, Kampik A, Girach A, Pakola S, Haller JA, MIVI-TRUST Study Group (2012) Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes. N Engl J Med 367:606–615. https://doi.org/10.1056/NEJMoa1110823 CrossRefPubMed

13.

Gaudric A, Aloulou Y, Tadayoni R, Massin P (2013) Macular pseudoholes with lamellar cleavage of their edge remain pseudoholes. Am J Ophthalmol 155:733–742. https://doi.org/10.1016/j.ajo.2012.10.021 CrossRefPubMed

14.

Govetto A, Dacquay Y, Farajzadeh M, Platner E, Hirabayashi K, Hosseini H, Schwartz SD, Hubschman JP (2016) Lamellar macular hole: two distinct clinical entities? Am J Ophthalmol 164:99–109. https://doi.org/10.1016/j.ajo.2016.02.008 CrossRefPubMed

15.

Zambarakji HJ, Schlottmann P, Tanner V, Assi A, Gregor ZJ (2005) Macular microholes: pathogenesis and natural history. Br J Ophthalmol 89:189–193CrossRef

16.

Scheibe P, Zocher MT, Francke M, Rauscher FG (2016) Analysis of foveal characteristics and their asymmetries in the normal population. Exp Eye Res 148:1–11. https://doi.org/10.1016/j.exer.2016.05.013 CrossRefPubMed

17.

Wong AC, Chan CW, Hui SP (2005) Relationship of gender, body mass index, and axial length with central retinal thickness using optical coherence tomography. Eye 19:292–297CrossRef

18.

Wagner-Schuman M, Dubis AM, Nordgren RN, Lei Y, Odell D, Chiao H, Weh E, Fischer W, Sulai Y, Dubra A, Carroll J (2011) Race- and sex-related differences in retinal thickness and foveal pit morphology. Invest Ophthalmol Vis Sci 52:625–634. https://doi.org/10.1167/iovs.10-5886 CrossRefPubMedPubMedCentral

19.

Grover S, Murthy RK, Brar VS, Chalam KV (2009) Normative data for macular thickness by high-definition spectral-domain optical coherence tomography (Spectralis). Am J Ophthalmol 148:266–271. https://doi.org/10.1016/j.ajo.2009.03.006 CrossRefPubMed

20.

Carpineto P, Nubile M, Toto L, Aharrh Gnama A, Marcucci L, Mastropasqua L, Ciancaglini M (2010) Correlation in foveal thickness measurements between spectral-domain and time-domain optical coherence tomography in normal individuals. Eye (Lond) 24:251–258. https://doi.org/10.1038/eye.2009.76 CrossRef

21.

Trieschmann M, Spital G, Lommatzsch A, van Kuijk E, Fitzke F, Bird AC, Pauleikhoff D (2003) Macular pigment: quantitative analysis on autofluorescence images. Graefes Arch Clin Exp Ophthalmol 24:1006–1012CrossRef

22.

Gass JD (1999) Müller cell cone, an overlooked part of the anatomy of the fovea centralis (1999). Arch Ophthalmol 117:821–823CrossRef

23.

Syrbe S, Kuhrtb H, Gärtnerc U, Habermann G, Wiedemann P, Bringmann A, Reichenbach A (2018) Müller glial cells of the primate foveola: an electron microscopical study. Exp Eye Res 167:110–117. https://doi.org/10.1016/j.exer.2017.12.004 CrossRefPubMed

Title: Foveal Abnormality associated with epiretinal Tissue of medium reflectivity and Increased blue-light fundus Autofluorescence Signal (FATIAS)
Authors: Roberto dell’Omo
Serena De Turris
Ciro Costagliola
Gianni Virgili
Ricarda G. Schumann
Matteo Cereda
Isabella D’Agostino
Ermanno dell’Omo
Ferdinando Bottoni
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 12/2019
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04451-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Foveal Abnormality associated with epiretinal Tissue of medium reflectivity and Increased blue-light fundus Autofluorescence Signal (FATIAS)

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 12/2019

Iris lens distance to predict the risk of intraocular pressure elevation after dark room provocative test

The effect of estrogen and progesterone on porcine corneal biomechanical properties

Multicenter survey of sutureless 27-gauge vitrectomy for primary rhegmatogenous retinal detachment: a consecutive series of 410 cases

Change in visual acuity 12 and 24 months after transscleral ab interno glaucoma gel stent implantation with adjunctive Mitomycin C

The STARflo™ glaucoma implant: a single-centre experience at 24 months

IOLs glistenings and quality of vision