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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-10-2019 | Glaucoma | Cornea

Effect of topical prostaglandins on the biomechanics and shape of the cornea

Authors: Shiro Amano, Ryohei Nejima, Kenji Inoue, Kazunori Miyata

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 10/2019

Abstract

Purpose

To investigate the effect of topical prostaglandin (PG) eyedrops on the biomechanics and shape of the cornea.

Methods

Consecutive patients with primary open-angle glaucoma who had been treated with the same anti-glaucoma PG (114 eyes, 57 patients) or β-blocker (36 eyes, 18 patients) eyedrops in 1 eye alone for more than 3 months at Inouye Eye Hospital or Miyata Eye Hospital. The biomechanical properties of the cornea were measured using a Corvis ST device (Oculus, Wetzlar, Germany). Corneal tomography was measured with a Casia 1 or 2 (Tomey Corp., Nagoya, Japan). The biomechanical parameters and tomographic features of the cornea were compared between PG-treated eyes, β-blocker-treated eyes, and contralateral eyes using a mixed-effect model adjusted for intraocular pressure and corneal thickness and a linear model adjusted for age, sex, intraocular pressure, and corneal thickness.

Results

The PG-treated eyes had a significantly smaller applanation 1 time, the highest concavity radius, and a larger deformation amplitude than the contralateral eyes. Also, the PG-treated eyes had a significantly smaller applanation 1 time and applanation 2 velocity but a larger peak distance than the β-blocker-treated eyes. There were no significant differences in any of the Casia parameters between the PG-treated eyes and the contralateral eyes.

Conclusion

The results of this study suggest that topical PG makes biochemical changes to the cornea but does not alter its shape.

Toris CB, Gabelt BT, Kaufman PL (2008) Update on the mechanism of action of topical prostaglandins for intraocular pressure reduction. Surv Ophthalmol 53(Suppl1):S107–S120CrossRef

Weinreb RN, Kashiwagi K, Kashiwagi F, Tsukahara S, Lindsey JD (1997) Prostaglandins increase matrix metalloproteinase release from human ciliary smooth muscle cells. Invest Ophthalmol Vis Sci 38:2772–2780PubMed

Lindsey JD, Kashiwagi K, Boyle D, Kashiwagi F, Firestein GS, Weinreb RN (1996) Prostaglandins increase proMMP-1 and proMMP-3 secretion by human ciliary smooth muscle cells. Curr Eye Res 15:869–875CrossRef

Lindsey JD, Kashiwagi K, Kashiwagi F, Weinreb RN (1997) Prostaglandins alter extracellular matrix adjacent to human ciliary muscle cells in vitro. Invest Ophthalmol Vis Sci 38:2214–2223PubMed

Honda N, Miyai T, Nejima R et al (2010) Effect of latanoprost on the expression of matrix metalloproteinases and tissue inhibitor of metalloproteinase 1 on the ocular surface. Arch Ophthalmol 128:466–471CrossRef

Lopilly Park HY, Kim JH, Lee KM, Park CK (2012) Effect of prostaglandin analogues on tear proteomics and expression of cytokines and matrix metalloproteinases in the conjunctiva and cornea. Exp Eye Res 94:13–21CrossRef

Wu N, Chen Y, Yu X, Li M, Wen W, Sun X (2016) Changes in corneal biomechanical properties after long-term topical prostaglandin therapy. PLoS One 11:e0155527CrossRef

Meda R, Wang Q, Paoloni D, Harasymowycz P, Brunette I (2017) The impact of chronic use of prostaglandin analogues on the biomechanical properties of the cornea in patients with primary open-angle glaucoma. Br J Ophthalmol 101:120–125CrossRef

Lema I, Duran JA (2005) Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology 112:654–659CrossRef

10.

Shetty R, Ghosh A, Lim RR et al (2015) Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A. Invest Ophthalmol Vis Sci 56:738–750CrossRef

11.

Hallahan K, Dupps W Jr, Roberts C (2018) Deformation response to an air puff: clinical methods. In: Roberts C, Dupps WJ, Downs C (eds) Biomechanics of the eye. Kugler Publications, Amsterdam

12.

Ali NQ, Patel DV, McGhee CN (2014) Biomechanical responses of healthy and keratoconic corneas measured using a noncontact Scheimpflug-based tonometer. Invest Ophthalmol Vis Sci 55:3651–3659CrossRef

13.

Francis M, Pahuja N, Shroff R et al (2017) Waveform analysis of deformation amplitude and deflection amplitude in normal, suspect, and keratoconic eyes. J Cataract Refract Surg 43:1271–1280CrossRef

14.

Elham R, Jafarzadehpur E, Hashemi H et al (2017) Keratoconus diagnosis using Corvis ST measured biomechanical parameters. J Curr Ophthalmol 29:175–181CrossRef

15.

Wang W, Du S, Zhang X (2015) Corneal deformation response in patients with primary open-angle glaucoma and in healthy subjects analyzed by Corvis ST. Invest Ophthalmol Vis Sci 56:5557–5565CrossRef

16.

Mietz H, Esser JM, Welsandt G et al (2003) Latanoprost stimulates secretion of matrix metalloproteinases in Tenon fibroblasts both in vitro and in vivo. Invest Ophthalmol Vis Sci 44:5182–5188CrossRef

17.

Catalan-Lopez S, Cadarso-Suarez L, Lopez-Raton M, Cadarso-Suarez C (2018) Corneal biomechanics in unilateral keratoconus and fellow eyes with a Scheimpflug-based tonometer. Optom Vis Sci 95:608–615CrossRef

18.

Amano S, Nakai Y, Ko A, Inoue K, Wakakura M (2008) A case of keratoconus progression associated with the use of topical latanoprost. Jpn J Ophthalmol 52:334–336CrossRef

Title: Effect of topical prostaglandins on the biomechanics and shape of the cornea
Authors: Shiro Amano
Ryohei Nejima
Kenji Inoue
Kazunori Miyata
Publication date: 01-10-2019
Publisher: Springer Berlin Heidelberg
Keyword: Glaucoma
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 10/2019
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04435-7

2024 ASCO Annual Meeting

Springer Medicine

Effect of topical prostaglandins on the biomechanics and shape of the cornea

Abstract

Purpose

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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