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Graefe's Archive for Clinical and Experimental Ophthalmology

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Open Access 01-01-2019 | Glaucoma

Efficacy of glaucoma drainage devices in uveitic glaucoma and a meta-analysis of the literature

Authors: Wishal D. Ramdas, Jan Pals, Aniki Rothova, Roger C. W. Wolfs

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 1/2019

Abstract

Purpose

To assess the efficacy of glaucoma drainage devices (GDD) in uveitic glaucoma and non-uveitic glaucoma, and to perform a meta-analysis of previously published results to compare with our data.

Methods

Retrospective case-control study, in which all eyes that underwent GDD surgery were included from 2015 onwards. Cases were defined as patients with uveitic glaucoma. Patients with non-uveitic glaucoma served as controls. To compare our results, a review of the literature was performed using PubMed database.

Results

A total of 99 eyes were included (38 with uveitic glaucoma). The preoperative IOP was 25.9 ± 7.7 mmHg and 27.9 ± 9.6 mmHg for patients with and without uveitis (p = 0.277). No significant differences were found between patients with and without uveitis in the final IOP or reduction in IOP (44.9% vs. 42.8%, respectively). Within the first year after surgery, 13.2% of cases developed macular edema (vs. 6.6%; p = 0.267) and 15.8% a transient hypotony (vs. 8.2%; p = 0.242). A meta-analysis of 24 studies showed a postoperative weighted mean difference of − 17.8 mmHg and 2.2 lower number of IOP-lowering medications in uveitic glaucoma (compared to − 13.2 mmHg and 3.5 in the current study, respectively).

Conclusion

GDD surgery in patients with uveitis has a similar effect on IOP as in patients without uveitis. The risks of developing macular edema and hypotony were slightly higher in patients with uveitis, but the results were not statistically significant. These findings are in line with previous reports, though data on the efficacy of GDD surgery and macular edema in uveitic glaucoma is scarce.

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Title: Efficacy of glaucoma drainage devices in uveitic glaucoma and a meta-analysis of the literature
Authors: Wishal D. Ramdas
Jan Pals
Aniki Rothova
Roger C. W. Wolfs
Publication date: 01-01-2019
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 1/2019
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-018-4156-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Efficacy of glaucoma drainage devices in uveitic glaucoma and a meta-analysis of the literature

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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