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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-11-2015 | Review Article

The effect of flavonoids on visual function in patients with glaucoma or ocular hypertension: a systematic review and meta-analysis

Authors: Shaheen Patel, Joyce J. Mathan, Ehsan Vaghefi, Andrea J. Braakhuis

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2015

Abstract

Background

Glaucoma is a leading cause of irreversible blindness worldwide. A major symptom of this pathology is the loss to the visual field in a peripheral to central pattern. Flavonoids are polyphenol compounds sourced from plants, commonly found in green tea, red wine and cocoa, and they have neuroprotective and antioxidant characteristics proposed to be advantageous within the context of glaucoma. Currently, the literature presents conflicting evidence regarding the effect of flavonoids on patients with glaucoma and ocular hypertension; hence a systematic review and meta-analysis was conducted.

Method

Databases included in our literature search were EMBASE (1980-present), MEDLINE Ovid, Alternative and Complementary Medicine Database (AMED), Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Cochrane Central Register of Controlled Trials (CENTRAL). Meta-analysis was performed using RevMan 5 (Review Manager) 5 software, version 5.3 (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen). The primary outcomes were visual field mean deviation (MD) and intraocular pressure (IOP). Secondary outcomes were ocular blood flow and blood pressure (BP).

Conclusion

Meta-analyses showed that flavonoids have a promising role in improving visual function in patients with glaucoma and ocular hypertension (OHT), and appear to play a part in both improving and slowing the progression of visual field loss.

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Title: The effect of flavonoids on visual function in patients with glaucoma or ocular hypertension: a systematic review and meta-analysis
Authors: Shaheen Patel
Joyce J. Mathan
Ehsan Vaghefi
Andrea J. Braakhuis
Publication date: 01-11-2015
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2015
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-015-3168-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The effect of flavonoids on visual function in patients with glaucoma or ocular hypertension: a systematic review and meta-analysis

Abstract

Background

Method

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Conclusion

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