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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-12-2015 | Retinal Disorders

Comparison of visual and anatomical outcomes of half-fluence and half-dose photodynamic therapy in eyes with chronic central serous chorioretinopathy

Authors: Yong-Kyu Kim, Na-Kyung Ryoo, Se Joon Woo, Kyu Hyung Park

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 12/2015

Abstract

Purpose

To compare visual and anatomical outcomes of half-fluence (HF) and half-dose (HD) photodynamic therapy (PDT) in chronic central serous chorioretinopathy (CSC). Particular focus was given to photoreceptor recovery rate following treatment.

Methods

Retrospective review of 52 chronic CSC patients who underwent HF- or HD-PDT (26 patients per group). Best-corrected visual acuity and spectral-domain optical coherence tomography findings were compared between groups.

Results

Average follow-up for HF- and HD-PDT was 20.7 ± 7.2 and 22.3 ± 6.1 months respectively. Both groups had significant visual acuity improvements, as well as central foveal and subfoveal choroidal thickness reductions. Measured parameters were not significantly different between groups at any time point examined. Complete photoreceptor recovery, defined as a continuous ellipsoid zone with a discernible interdigitation zone, was observed at 12 months in 19 (73 %) and 14 patients (54 %) in the HF- and HD-PDT groups respectively (p = 0.150). Overall photoreceptor recovery rate was not different between groups (p = 0.301, log-rank test). Delayed (>12 months) photoreceptor recovery was significantly associated with baseline external limiting membrane disruption (OR: 21.7, 95 % CI: 1.7–285.4, p = 0.019), disease duration (years, OR: 1.9, 95 % CI: 1.2–3.0, p = 0.005), and fovea-to-PDT spot center distance (100 μm unit, OR: 0.74, 95 % CI 0.56–0.97, p = 0.027). However, delayed photoreceptor recovery was not significantly associated with PDT modality.

Conclusion

Both HF- and HD-PDT are effective in treating chronic CSC. No significant differences in visual or anatomical outcomes were observed.

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Title: Comparison of visual and anatomical outcomes of half-fluence and half-dose photodynamic therapy in eyes with chronic central serous chorioretinopathy
Authors: Yong-Kyu Kim
Na-Kyung Ryoo
Se Joon Woo
Kyu Hyung Park
Publication date: 01-12-2015
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 12/2015
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-014-2926-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparison of visual and anatomical outcomes of half-fluence and half-dose photodynamic therapy in eyes with chronic central serous chorioretinopathy

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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