Top

Graefe's Archive for Clinical and Experimental Ophthalmology

Published in:

01-09-2012 | Retinal Disorders

Pulse-wave analysis of optic nerve head circulation is significantly correlated with brachial–ankle pulse-wave velocity, carotid intima–media thickness, and age

Authors: Tomoaki Shiba, Mao Takahashi, Yuichi Hori, Takatoshi Maeno

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 9/2012

Abstract

Background

To determine whether there is a significant correlation between the pulse-wave analysis in the optic nerve head circulation determined by laser speckle flowgraphy (LSFG), and brachial–ankle pulse wave velocity (baPVW), carotid intima–media thickness (IMT), and age.

Methods

Thirty-three patients who visited the Vascular Function Section in our hospital were included. Age was 57.3 ± 12.6 years, with a range from 29 to 80 years. baPVW, carotid IMT, and pulse wave analysis in optic nerve head circulation using LSFG were conducted on subjects, and this parameter is named blowout time (BOT). The following items were analyzed as other systemic parameters: age, blood pressure, pulse pressure, heart rate, body mass index, and mean arterial blood pressure; other ocular parameters were intraocular pressure and ocular perfusion pressure. Pearson’s correlation coefficients were used to determine the relationship between the BOT, baPWV, IMT, age, and other parameters. In addition, multiple regression analysis was used to determine independent factors for age.

Results

BOT was significantly correlated with age (r = −0.85, P <0.0001), pulse pressure (r = −0.36, P = 0.04), baPWV (r = −0.72, P <0.0001), and IMT (r = −0.64, P < 0.0001). The result of multiple regression analysis showed that baPWV (odds ratio = 0.93, 95% confidence interval = 0.03–1.82 P = 0.04) and BOT (−2.26, −3.27 to −1.26, <0.0001) were independent contribution factors to age.

Conclusions

Our results confirmed measurements of BOT in the optic nerve head can be a useful method for determinin g whether early atherosclerotic changes are present in the optic nerve head circulation.

Pinto E (2007) Blood pressure and ageing. Postgrad Med J 83:109–114PubMedCrossRef

Mitchell P, Smith W, Chang A (1996) Prevalence and associations of retinal vein occlusion in Australia. The Blue Mountains Eye Study. Arch Ophthalmol 114:1243–1247PubMedCrossRef

Yasuda M, Kiyohara Y, Arakawa S, Hata Y, Yonemoto K, Doi Y, Iida M, Ishibashi T (2010) Prevalence and systemic risk factors for retinal vein occlusion in a general Japanese population: the Hisayama study. Invest Ophthalmol Vis Sci 51:3205–3209PubMedCrossRef

Hayreh SS, Zimmerman MB, Podhajsky P (1994) Incidence of various types of retinal vein occlusion and their recurrence and demographic characteristics. Am J Ophthalmol 117:429–441PubMed

Miyazaki M, Nakamura H, Kubo M, Kiyohara Y, Oshima Y, Ishibashi T, Nose Y (2003) Risk factors for age related maculopathy in a Japanese population: the Hisayama study. Br J Ophthalmol 87:469–472PubMedCrossRef

Miyazaki M, Kiyohara Y, Yoshida A, Iida M, Nose Y, Ishibashi T (2005) The 5-year incidence and risk factors for age-related maculopathy in a general Japanese population: the Hisayama study. Invest Ophthalmol Vis Sci 46:1907–1910PubMedCrossRef

Kaderli AA, Kaderli B, Gullulu S, Avci R (2010) Impaired aortic stiffness and pulse wave velocity in patients with branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 248:369–374PubMedCrossRef

Sato E, Feke GT, Appelbaum EY, Menke MN, Trempe CL, McMeel JW (2006) Association between systemic arterial stiffness and age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 244:963–971PubMedCrossRef

Klein R, Klein BE, Knudtson MD, Cotch MF, Wong TY, Liu K, Burke GL, Saad MF, Jacobs DR Jr, Sharrett AR (2007) Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of Atherosclerosis. Arch Ophthalmol 125:534–543PubMedCrossRef

10.

Lehmann ED (1999) Clinical value of aortic pulse-wave velocity measurement. Lancet 354:528–529PubMedCrossRef

11.

Asmar R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac AM, Target R, Levy BI (1995) Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension 26:485–490PubMedCrossRef

12.

Suzuki E, Kashiwagi A, Nishio Y, Egawa K, Shimizu S, Maegawa H, Haneda M, Yasuda H, Morikawa S, Inubushi T, Kikkawa R (2001) Increased arterial wall stiffness limits flow volume in the lower extremities in type 2 diabetic patients. Diabetes Care 24:2107–2114PubMedCrossRef

13.

Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K, Koji Y, Hori S, Yamamoto Y (2002) Validity, reproducibility, and clinical significance of noninvasive brachial–ankle pulse wave velocity measurement. Hypertens Res 25:359–364PubMedCrossRef

14.

Matsushima Y, Kawano H, Koide Y, Baba T, Toda G, Seto S, Yano K (2004) Relationship of carotid intima–media thickness, pulse wave velocity, and ankle brachial index to the severity of coronary artery atherosclerosis. Clin Cardiol 27:629–634PubMedCrossRef

15.

Wofford JL, Kahl FR, Howard GR, McKinney WM, Toole JF, Crouse JR 3rd (1991) Relation of extent of extracranial carotid artery atherosclerosis as measured by B-mode ultrasound to the extent of coronary atherosclerosis. Arterioscler Thromb 11:1786–1794PubMedCrossRef

16.

Craven TE, Ryu JE, Espeland MA, Kahl FR, McKinney WM, Toole JF, McMahan MR, Thompson CJ, Heiss G, Crouse JR 3rd (1990) Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis. A case-control study. Circulation 82:1230–1242PubMedCrossRef

17.

Tomiyama H, Yamashina A, Arai T, Hirose K, Koji Y, Chikamori T, Hori S, Yamamoto Y, Doba N, Hinohara S (2003) Influences of age and gender on results of noninvasive brachial–ankle pulse wave velocity measurement—a survey of 12517 subjects. Atherosclerosis 166:303–309PubMedCrossRef

18.

Sun Y, Lin CH, Lu CJ, Yip PK, Chen RC (2002) Carotid atherosclerosis, intima media thickness and risk factors—an analysis of 1781 asymptomatic subjects in Taiwan. Atherosclerosis 164:89–94PubMedCrossRef

19.

Tamaki Y, Araie M, Kawamoto E, Eguchi S, Fujii H (1995) Non-contact, two-dimensional measurement of tissue circulation in choroid and optic nerve head using laser speckle phenomenon. Exp Eye Res 60:373–383PubMedCrossRef

20.

Isono H, Kishi S, Kimura Y, Hagiwara N, Konishi N, Fujii H (2003) Observation of choroidal circulation using index of erythrocytic velocity. Arch Ophthalmol 121:225–231PubMedCrossRef

21.

Fujii H (1994) Visualisation of retinal blood flow by laser speckle flowgraphy. Med Biol Eng Comput 32:302–304PubMedCrossRef

22.

Shirai K, Utino J, Otsuka K, Takata M (2006) A novel blood pressure-independent arterial wall stiffness parameter; cardio–ankle vascular index (CAVI). J Atheroscler Thromb 13:101–107PubMedCrossRef

23.

Takiuchi S, Kamide K, Miwa Y, Tomiyama M, Yoshii M, Matayoshi T, Horio T, Kawano Y (2004) Diagnostic value of carotid intima–media thickness and plaque score for predicting target organ damage in patients with essential hypertension. J Hum Hypertens 18:17–23PubMedCrossRef

24.

O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr (1999) Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340:14–22PubMedCrossRef

25.

Ishikawa T, Hashimoto J, Morito RH, Hanazawa T, Aikawa T, Hara A, Shintani Y, Metoki H, Inoue R, Asayama K, Kikuya M, Ohkubo T, Totsune K, Hoshi H, Satoh H, Imai Y (2008) Association of microalbuminuria with brachial–ankle pulse wave velocity: the Ohasama study. Am J Hypertens 21:413–418PubMedCrossRef

26.

Sugiyama T, Araie M, Riva CE, Schmetterer L, Orgul S (2010) Use of laser speckle flowgraphy in ocular blood flow research. Acta Ophthalmol 88:723–729PubMedCrossRef

27.

Nagaoka T, Sato E, Takahashi A, Sogawa K, Yokota H, Yoshida A (2009) Effect of aging on retinal circulation in normotensive healthy subjects. Exp Eye Res 89:887–891PubMedCrossRef

28.

Nagaoka T, Ishii Y, Takeuchi T, Takahashi A, Sato E, Yoshida A (2005) Relationship between the parameters of retinal circulation measured by laser Doppler velocimetry and a marker of early systemic atherosclerosis. Invest Ophthalmol Vis Sci 46:720–725PubMedCrossRef

29.

Yambe M, Tomiyama H, Hirayama Y, Gulniza Z, Takata Y, Koji Y, Motobe K, Yamashina A (2004) Arterial stiffening as a possible risk factor for both atherosclerosis and diastolic heart failure. Hypertens Res 27:625–631PubMedCrossRef

Title: Pulse-wave analysis of optic nerve head circulation is significantly correlated with brachial–ankle pulse-wave velocity, carotid intima–media thickness, and age
Authors: Tomoaki Shiba
Mao Takahashi
Yuichi Hori
Takatoshi Maeno
Publication date: 01-09-2012
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 9/2012
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-012-1952-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Pulse-wave analysis of optic nerve head circulation is significantly correlated with brachial–ankle pulse-wave velocity, carotid intima–media thickness, and age

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 9/2012

Descemet's stripping endothelial keratoplasty (DSEK) for children with congenital hereditary endothelial dystrophy: surgical challenges and 1-year outcomes

Short- and mid-term repeatability of macular pigment optical density measurements using spectral fundus reflectance

Pupil dynamics in Chinese subjects with angle closure

Vascularized retinal pigment epithelial detachment in age-related macular degeneration: treatment and RPE tear incidence

Complication rate and risk factors for intraoperative complications in resident-performed phacoemulsification surgery

Visual status and ocular morbidity in older adults living in residential care