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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-08-2011 | Retinal Disorders

Subfoveal choroidal thickness in typical age-related macular degeneration and polypoidal choroidal vasculopathy

Authors: Hideki Koizumi, Tetsuya Yamagishi, Taizo Yamazaki, Ryo Kawasaki, Shigeru Kinoshita

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 8/2011

Abstract

Purpose

To investigate the subfoveal choroidal thickness in eyes with typical age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV), using enhanced depth imaging optical coherence tomography.

Methods

Retrospective observational case series of 44 eyes of 44 patients (12 females and 32 males) with typical AMD or PCV located in the subfoveal region. Cross-sectional images of the choroid of each of the involved eyes were obtained by a spectral-domain OCT. The choroidal thickness under the fovea was retrospectively studied.

Results

Of the 44 eyes involved in this study, 21 eyes were diagnosed as typical AMD and the other 23 eyes were diagnosed as PCV. The difference in subfoveal choroidal thickness between the eyes with typical AMD (245 μm) and those with PCV (293 μm) was statistically significant, even after adjusting for age, spherical equivalent, and gender distribution (P = 0.045). When compared to eyes with subfoveal choroidal thickness less than 300 μm, those with subfoveal choroidal thickness of 300 μm or more were 5.6 times more likely to have PCV (adjusted odds ratio 5.60, 95% confidence interval 1.30–24.0, P = 0.021).

Conclusions

The choroid under the fovea was thicker in eyes with PCV than those with typical AMD. This result suggests that the choroidal vascular lesion seen in PCV may not be just the choroidal neovascularization accompanied by saccular capillary dilations at the border, but may have a significant structural difference in the choroid compared to typical AMD.

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Title: Subfoveal choroidal thickness in typical age-related macular degeneration and polypoidal choroidal vasculopathy
Authors: Hideki Koizumi
Tetsuya Yamagishi
Taizo Yamazaki
Ryo Kawasaki
Shigeru Kinoshita
Publication date: 01-08-2011
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 8/2011
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-011-1620-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Subfoveal choroidal thickness in typical age-related macular degeneration and polypoidal choroidal vasculopathy

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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