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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-12-2010 | Retinal Disorders

Choroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography

Authors: Jonathan Yeoh, Waheeda Rahman, Fred Chen, Claire Hooper, Praveen Patel, Adnan Tufail, Andrew R. Webster, Anthony T. Moore, Lyndon DaCruz

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 12/2010

Abstract

Purpose

The aim of this study is to image and describe the in vivo choroidal changes in various retinal dystrophies using the technique of enhanced depth imaging (EDI) optical coherence tomography (OCT) and to correlate these findings with the clinical appearance. Associations between choroidal change and genotype, visual acuity and results of retinal electrophysiology are also explored.

Design

Retrospective observational case series.

Methods

Twenty patients attending the medical retina clinics at Moorfields Eye Hospital underwent EDI OCT choroidal scans as part of the scanning protocol when they underwent OCT imaging with the Spectralis HRA and OCT. The choroidal images were obtained by moving the Spectralis camera close enough to obtain an inverted image of the retina. The scans were read by two experienced OCT readers assessing the choroidal thickness as well as the choroidal contour for focal areas of choroidal thinning corresponding to the areas of RPE/outer retinal atrophy. The spectrum of patients included those with Stargardt macular dystrophy, macular dystrophies secondary to known mutations such as peripherin/RDS, uncharacterised macular dystrophies, Best disease, bifocal chorioretinal atrophy, Bietti crystalline retinal dystrophy and choroideraemia.

Results

The choroidal appearance was symmetrical in all patients who had both eyes scanned. Ten patients showed no choroidal thinning, five had focal mild to moderate choroidal thinning, three had focal severe choroidal thinning, and two patients had diffuse severe choroidal thinning. There was no association between choroidal thinning and visual acuity [Fisher’s exact test, p = 0.350 (right eye), p = 1.000 (left eye)], or extent of retinal dysfunction on electrophysiology (Fisher’s exact test, p = 1.000).

Conclusion

Enhanced depth imaging using spectral domain OCT can be used to identify choroidal changes in inherited retinal disease. The pattern of choroidal change correlates well with the clinical appearance. It appears that the extent and pattern of choroidal thinning is dependent on the stage of the disease in some cases, and in others the causative gene defect.

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Title: Choroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography
Authors: Jonathan Yeoh
Waheeda Rahman
Fred Chen
Claire Hooper
Praveen Patel
Adnan Tufail
Andrew R. Webster
Anthony T. Moore
Lyndon DaCruz
Publication date: 01-12-2010
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 12/2010
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-010-1437-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Choroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography

Abstract

Purpose

Design

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Design

Methods

Results

Conclusion

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