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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 11/2010

01-11-2010 | Medical Ophthalmology

The effect of iodide iontophoresis on the antioxidative capacity of the tear fluid

Authors: Gebhard Rieger, Manfred Klieber, Wolfgang Schimetta, Werner Pölz, Sirid Griebenow, Rudolf Winkler, Jutta Horwath-Winter, Otto Schmut, Birgit Spitzer-Sonnleitner

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2010

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Abstract

Background

Environmental oxidative stress changing the properties of the tear fluid can lead to keratoconjunctivitis sicca (dry eye syndrome). The aim of this study was to determine whether iodide iontophoresis influences the antioxidative capacity (ACW = water soluble antioxidative capacity) of the tear fluid, and to compare iodide iontophoresis with other balneotherapeutic measures.

Methods

This prospective study evaluated 92 patients in four groups. Twenty-four patients were treated with iodide iontophoresis, 24 with other balneotherapeutic methods. Twenty-five patients received iodide iontophoresis combined with other balneotherapeutic methods and 21 persons received no treatment (control). Unstimulated tear fluid, serum and urine were collected. ACW was determined photochemically in tear fluid and serum; iodine was measured in urine photometrically.

Results

Iodide iontophoresis increases the ACW of the tear fluid but not the ACW of the serum. Other iodine therapies increase the ACW in serum but not in tear fluid. Iodine excretion in urine was increased in all treated groups compared to the control.

Conclusion

The increase of ACW in tear fluid after iodide iontophoresis can support the defense mechanism of the eye against oxidative influence effects, which may alleviate the symptoms of keratoconjunctivitis sicca.
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Metadata
Title
The effect of iodide iontophoresis on the antioxidative capacity of the tear fluid
Authors
Gebhard Rieger
Manfred Klieber
Wolfgang Schimetta
Werner Pölz
Sirid Griebenow
Rudolf Winkler
Jutta Horwath-Winter
Otto Schmut
Birgit Spitzer-Sonnleitner
Publication date
01-11-2010
Publisher
Springer-Verlag
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2010
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-010-1416-8

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