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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-04-2010 | Inflammatory Disorders

Intraocular antibody synthesis against rubella virus and other microorganisms in Fuchs' heterochromic cyclitis

Authors: Peter C. Ruokonen, Sylvia Metzner, Aylin Ücer, Necip Torun, Jörg Hofmann, Uwe Pleyer

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 4/2010

Abstract

Introduction

Fuchs' heterochromic cyclitis (FHC) is a common intraocular disease of uncertain etiology that has recently been related to rubella virus (RV) infection.

Methods

We investigated the synthesis of RV-specific IgG using aqueous humor and serum samples from 63 consecutive patients with FHC. In addition, intraocular immunoglobulin G production against herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV) and toxoplasma gondii was determined. In 20 patients, the detection of RV RNA was additionally performed by RT-PCR on the E1 gene. Forty-six patients with HSV- and VZV-associated uveitis, HLA B-27 positive anterior uveitis, and Posner–Schlossman syndrome served as controls.

Results

Specific intraocular antibody synthesis against RV was confirmed in all 63 FHC patients, whereas none of the 46 controls was positive for RV IgG. Interestingly, in 11 patients with positive RV IgG synthesis, additional HSV (eight), VZV (one) and CMV (two) specific antibodies could be detected. Only twice was viral RNA detectable by PCR in a patient with FHC.

Conclusions

In this largest reported series of FHC patients, we detected a strong association between FHC and intraocular antibody synthesis against rubella virus. Furthermore, in 11 patients, it was possible to confirm an additional intraocular antibody synthesis, in particular HSV. PCR-positive results in the aqueous humor were exclusively obtained for RV. In contrast to other studies, the RV genome could only be identified in two patients (10%).

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Title: Intraocular antibody synthesis against rubella virus and other microorganisms in Fuchs' heterochromic cyclitis
Authors: Peter C. Ruokonen
Sylvia Metzner
Aylin Ücer
Necip Torun
Jörg Hofmann
Uwe Pleyer
Publication date: 01-04-2010
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 4/2010
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-009-1239-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intraocular antibody synthesis against rubella virus and other microorganisms in Fuchs' heterochromic cyclitis

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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