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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-01-2007 | Case Report

Bilateral epibulbar granulocytic sarcomas: a case of an 8-year-old girl with acute myeloid leukaemia

Authors: Caroline Rosenberg, Paul T. Finger, Louis Furlan, Codrin E. Iacob

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 1/2007

Abstract

Purpose

An 8-year-old girl with a history of acute myeloid leukaemia (AML) presented with bilateral ocular discomfort, conjunctival injection, photophobia, and epiphora.

Methods

Clinical examination and high-frequency ultrasound showed bilateral epibulbar tumours.

Results

Granulocytic sarcomas were suspected and leukaemic infiltration was confirmed by fine-needle aspiration biopsy based cytopathologic examination.

Conclusions

Epibulbar granulocytic sarcoma in AML is rare (particularly in a child). We describe the first high-frequency ultrasound images and illustrate the use of a minimally invasive fine-needle aspiration biopsy technique to confirm our diagnosis.

Byrd JC, Edenfield WJ, Shields DJ, Dawson NA (1995) Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review. J Clin Oncol 13:1800–1816PubMed

Chefchaouni AC, Belmekki M, Hajji Z, Tahiri H, Amrani R, Bakkali ME, Alaoui FM, Berraho A (2002) Ophthalmic manifestations of acute leukemia. J Fr Ophthalmol 25:62–66

Douglas RS, Goldstein SM, Nichols C (2002) Acute myelogenous leukaemia presenting as a conjunctival lesion and red eye. Acta Ophthalmol Scand 80:671–672PubMedCrossRef

Fleckenstein K, Geinitz H, Grosu A, Goetze K, Werner M, Molls M (2003) Irradiation for conjunctival granulocytic sarcoma. Strahlenther Onkol 179:187–190PubMedCrossRef

Hon C, Shek TW, Liang R (2002) Conjunctival chloroma (granulocytic sarcoma). Lancet 359:2247PubMedCrossRef

Karesh JW, Goldman EJ, Reck K, Kelman SE, Lee EJ, Schiffer CA (1987) A prospective ophthalmic evaluation of patients with acute myeloid leukemia: correlation of ocular and hematologic findings. J Clin Oncol 7:1528–1532

Kincaid MC, Green WR (1983) Ocular and orbital involvement in leukemia. Surv Ophthalmol 27:211–232PubMedCrossRef

Lee SS, Robinson MR, Morris JC, Mirtsching BC, Shen D, Chan CC (2004) Conjunctival involvement with T-cell prolymphocytic leukemia: report of a case and review of the literature. Surv Ophthalmol 49:525–536PubMedCrossRef

Pui MH, Fletcher BD, Langston JW (1994) Granulocytic sarcoma in childhood leukemia: imaging features. Radiology 190:698–702PubMed

10.

Slavin S, Naparstek E, Nagler A, Ackerstein A, Kapelushnik J, Or R (1995) Allogeneic cell therapy for relapsed leukemia after bone marrow transplantation with donor peripheral blood lymphocytes. Exp Hematol 23:1553–1562PubMed

11.

Zimmerman LE, Font RL (1975) Ophthalmologic manifestations of granulocytic sarcoma (myeloid sarcoma or chloroma): the third Pan American Association of Ophthalmology and American Journal of Ophthalmology lecture. Am J Ophthalmol 80:975–990PubMed

Title: Bilateral epibulbar granulocytic sarcomas: a case of an 8-year-old girl with acute myeloid leukaemia
Authors: Caroline Rosenberg
Paul T. Finger
Louis Furlan
Codrin E. Iacob
Publication date: 01-01-2007
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 1/2007
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-006-0341-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Bilateral epibulbar granulocytic sarcomas: a case of an 8-year-old girl with acute myeloid leukaemia

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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