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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-02-2007 | Short Communication

Endothelial nitric oxide synthase gene polymorphisms in non-arteritic anterior ischemic optic neuropathy

Authors: Tsutomu Sakai, Keigo Shikishima, Masato Matsushima, Kenji Kitahara

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 2/2007

Abstract

Background

To examine the association between the polymorphisms of the endothelial nitric oxide synthase (eNOS) gene and the occurrence of non-arteritic anterior ischemic optic neuropathy (NAION).

Methods

We studied 15 patients with NAION (mean age, 62 years; 60% male). We investigated two polymorphisms of the eNOS gene, Glu298Asp polymorphism of exon 7 and T(–786)C polymorphism of the promoter region. The genotype distribution in NAION was compared with the control (mean age, 63 years; 63% male) distribution.

Results

There was no significant difference in the genotype distribution of the Glu298Asp polymorphism between the NAION and control groups (P=1.000), whereas the genotype distribution of the T(–786)C polymorphism varied significantly between the patients with NAION and control subjects (P=0.002). After adjusting on covariates, individuals with the CC genotype of the T(–786)C polymorphism were more likely to develop NAION compared with those with TT genotype (odds ratio=0.09: 95% CI 0.01–0.86).

Conclusions

We found an increased prevalence of T(–786)C polymorphism of the eNOS gene in patients with NAION. Our data suggest that the T(–786)C polymorphism of the eNOS gene may be an important risk factor in the development of NAION in Japanese subjects.

Beck RW, Gamel JW, Willcourt RJ et al (1980) Acute ischemic optic neuropathy in severe preeclampsia. Am J Ophthalmol 90:342–346PubMed

Boulanger C, Luscher TF (1990) Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. J Clin Invest 85: 587–590PubMed

De Caterina R, Libby P, Peng HB et al (1995) Nitric oxide decreases cytokine-induced endothelial activation: nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 96:60–68PubMedCrossRef

Gomma AH, Elrayess MA, Knight CJ et al (2002) The endothelial nitric oxide synthase (Glu298Asp and –786T>C) gene polymorphisms are associated with coronary in–stent restenosis. Eur Heart J 23:1955–1962PubMedCrossRef

Hayreh SS, Zimmerman MB, Podhajsky P, Alward WL (1994) Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders. Am J Ophthalmol 117:603–624PubMed

Hayreh SS (1996) Acute ischemic disorders of the optic nerve: pathogenesis, clinical manifestations, and management. In: Katz B, ed. Ophthalmology Clinics of North America: transient monocular visual loss. WB Saunders Co., Philadelphia, Pa., pp 407–412

Ischemic Optic Neuropathy Decompression Trial Research Group (1996) Characteristics of patients with nonarteritic anterior ischemic optic neuropathy eligible for the Ischemic Optic Neuropathy Decompression Trial. Arch Ophthalmol 114:1366–1374

Kim JU, Chang HK, Lee SS et al (2003) Endothelial nitric oxide synthase gene polymorphisms in Behçet’s disease and rheumatic diseases with vasculitis. Ann Rheum Dis 62: 1083–1087PubMedCrossRef

Kubes P, Suzuki M, Granger DN (1991) Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 88:4651–4655PubMedCrossRef

10.

Lessell S (1999) Nonarteritic anterior ischemic optic neuropathy. Arch Ophthalmol 117:386–388PubMed

11.

Nakayama M, Yasue H, Yoshimura M et al (1999) T^–786→C mutation in the 5′–flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 99:2864–2870PubMed

12.

Palmer RMJ, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524–526PubMedCrossRef

13.

Potarazu SV (1997) Ischemic optic neuropathy: models for mechanism of disease. Clin Neurosci 4:264–269PubMed

14.

Radmoski MW, Palmer RM, Moncada S (1987). Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet 2: 1057–1058CrossRef

15.

Radmoski MW, Palmer RM, Moncada S (1990) Characterization of the l-arginine:nitric oxide pathway in human platelets. Br J Pharmacol 101:325–328

16.

Rossi GP, Cesari M, Zanchetta M et al (2003) The T–786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study. J Am Coll Cardiol 41:930–937PubMedCrossRef

17.

Salvarani C, Casali B, Nicoli D et al (2003) Endothelial nitric oxide synthase gene polymorphisms in giant cell arteritis. Arthr Rheum 48:3219–3223PubMedCrossRef

18.

Shimasaki Y, Yasue H, Yoshimura M et al (1998) Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction. J Am Coll Cardiol 31:1506–1510PubMedCrossRef

19.

Takemoto M, Egashira K, Usui M et al (1997) Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats. J Clin Invest 99:278–287PubMed

20.

Tsujita Y, Baba S, Yamauchi R et al (2001) Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese: The Suita study. J Hypertens 19:1941–1948PubMedCrossRef

21.

Yamada Y, Izawa H, Ichihara S, Takatsu, Ishihara, Hirayama H, Sone T, Tanaka M, Yokota M (2002) Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med 347:1916–1923PubMedCrossRef

22.

Yoshimura M, Yasue H, Nakayama M et al (2000) Genetic risk factors for coronary artery spasm: significance of endothelial nitric oxide synthase gene T–786→C and missense Glu298Asp variants. J Invest Med 48:367–374

Title: Endothelial nitric oxide synthase gene polymorphisms in non-arteritic anterior ischemic optic neuropathy
Authors: Tsutomu Sakai
Keigo Shikishima
Masato Matsushima
Kenji Kitahara
Publication date: 01-02-2007
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 2/2007
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-005-0245-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Endothelial nitric oxide synthase gene polymorphisms in non-arteritic anterior ischemic optic neuropathy

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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