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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-07-2005 | Clinical Investigation

Response of retinal blood flow to systemic hyperoxia in smokers and nonsmokers

Authors: Barbara Wimpissinger, Hemma Resch, Fatmire Berisha, Günther Weigert, Leopold Schmetterer, Kaija Polak

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2005

Abstract

Background

We investigated the influence of chronic smoking on ocular vascular reactivity during breathing of 100% oxygen.

Methods

Retinal vascular reactivity was tested during inhalation of 100% oxygen over 10 min. The observer-masked two-cohort study was performed in 24 healthy male volunteers (12 smokers and 12 nonsmokers) using the Zeiss Retinal Vessel Analyzer and laser Doppler velocimetry. From these parameters retinal blood flow was calculated.

Results

Hyperoxia significantly decreased arterial (smokers: p<0.001 vs baseline; nonsmokers: p=0.003 vs baseline) and venous (smokers: p<0.001 vs baseline; nonsmokers: p<0.001 vs baseline) diameters. This decrease was significantly more pronounced in smokers (arterial diameter: p<0.001, venous diameter: p=0.003). Hyperoxia decreased venous blood flow velocity (smokers: p=0.02 vs baseline; nonsmokers: p<0.001 vs baseline) to a comparable degree (p=0.51). The two groups showed a comparable decrease in retinal blood flow during hyperoxia (smokers: p<0.001 vs baseline; nonsmokers: p<0.001 vs baseline; p=0.76 between groups). The decrease of PCO₂ during inhalation of 100% oxygen was significantly more pronounced in smokers than in nonsmokers (p=0.038).

Conclusion

The present study indicates an abnormal retinal vascular response to hyperoxia in smokers. Further studies are needed to identify possible neural or humoral factors involved in this shifted vasoconstrictory status in smokers.

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Title: Response of retinal blood flow to systemic hyperoxia in smokers and nonsmokers
Authors: Barbara Wimpissinger
Hemma Resch
Fatmire Berisha
Günther Weigert
Leopold Schmetterer
Kaija Polak
Publication date: 01-07-2005
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2005
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-004-1083-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Response of retinal blood flow to systemic hyperoxia in smokers and nonsmokers

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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