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Open Access 01-04-2022 | Multiple Sclerosis | Review

Multiple sclerosis epidemiological trends in Italy highlight the environmental risk factors

Authors: M. Puthenparampil, P. Perini, R. Bergamaschi, M. Capobianco, M. Filippi, P. Gallo

Published in: Journal of Neurology | Issue 4/2022

Abstract

Italy is definitely a high-risk country for multiple sclerosis (MS). Over the last 50 years, several epidemiological studies, including longitudinal surveys, have disclosed that MS incidence and prevalence in Italy mainland and Islands (Sardinia and Sicily) have progressively increased, picturing a semi-parabolic curve. Based on the comprehensive scrutiny of 58 papers, we conclude that the latitude risk gradient does not fit to the Italian map of MS. The genetic heterogeneity of the Italian ethnicities, that likely forms the basis of MS predisposition, does not account for the dramatic increase of MS incidence and prevalence observed in Italy over the last half century that, rather, seems better explained by the effect of environmental factors.

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Title: Multiple sclerosis epidemiological trends in Italy highlight the environmental risk factors
Authors: M. Puthenparampil
P. Perini
R. Bergamaschi
M. Capobianco
M. Filippi
P. Gallo
Publication date: 01-04-2022
Publisher: Springer Berlin Heidelberg
Keyword: Multiple Sclerosis
Published in: Journal of Neurology / Issue 4/2022
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-021-10782-5

2024 ASCO Annual Meeting

Springer Medicine

Multiple sclerosis epidemiological trends in Italy highlight the environmental risk factors

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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