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Journal of Neurology
Published in: Journal of Neurology 1/2021

01-01-2021 | Magnetic Resonance Imaging | Review

Psychiatric disorders in multiple sclerosis

Authors: Maddalena Sparaco, Luigi Lavorgna, Simona Bonavita

Published in: Journal of Neurology | Issue 1/2021

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Abstract

Background

Multiple sclerosis (MS) is characterized by a large spectrum of symptoms, involving all functional systems. Psychiatric symptoms are common in people with MS (pwMS) having an important impact on quality of life and on some features of MS (fatigue, sleep, disability, adherence to disease-modifying drugs). The main psychiatric disturbances in MS are depressive, bipolar, anxiety, schizophrenic and obsessive–compulsive syndromes.

Methods

Literature search for original articles and review in the databases, including PubMed and Scopus from 1959 to 2019.

Results and conclusion

Studies answering the aim of this review were selected and reported. Epidemiological and clinical aspects of psychiatric syndromes (PS) in MS as well as self-report diagnostic scales and radiological correlates of PS in MS are described. Moreover, some radiological studies about primary psychiatric disorders (PD) are reported to underline how gray matter atrophy, white matter abnormalities and corpus callosum involvement in these diseases, as features in common with MS, may explain the more frequent occurrence of PD in MS than in the general population.
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Metadata
Title
Psychiatric disorders in multiple sclerosis
Authors
Maddalena Sparaco
Luigi Lavorgna
Simona Bonavita
Publication date
01-01-2021
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 1/2021
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-019-09426-6

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