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01-09-2018 | Original Communication

Corpus callosal involvement is correlated with cognitive impairment in multiple system atrophy

Authors: Kazuhiro Hara, Hirohisa Watanabe, Epifanio Bagarinao, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Takashi Tsuboi, Mizuki Ito, Naoki Atsuta, Hisayoshi Niwa, Toshiaki Taoka, Satoshi Maesawa, Shinji Naganawa, Masahisa Katsuno, Gen Sobue

Published in: Journal of Neurology | Issue 9/2018

Abstract

Objective

We examined the anatomical involvement related to cognitive impairment in patients with multiple system atrophy (MSA).

Methods

We examined 30 patients with probable MSA and 15 healthy controls. All MSA patients were assessed by the Unified MSA-Rating scale and Addenbrooke’s Cognitive Examination-Revised (ACE-R). We classified 15 MSA patients with ACE-R scores > 88 as having normal cognition (MSA–NC) and 15 with scores ≤ 88 as having cognitive impairment (MSA–CI). All subjects underwent 3 T MRI scanning and were investigated using voxel-based morphometry and diffusion tensor imaging.

Results

Both the MSA–NC and MSA–CI patients exhibited cerebellar but not cerebral atrophy in voxel-based morphometry compared to controls. In contrast, tract-based spatial statistics revealed widespread and significantly decreased fractional anisotropy (FA) values, as well as increased mean diffusivity, radial diffusivity, and axial diffusivity in both the cerebrum and cerebellum in MSA–CI patients compared to controls. MSA–NC patients also exhibited similar involvement of the cerebellum but less extensive involvement of the cerebrum compared with the MSA–CI patients. In particular, FA values in MSA–CI patients were significantly decreased in the anterior part of the left corpus callosum compared with those in MSA–NC patients. The mean FA values in the left anterior part of the corpus callosum were significantly correlated with total ACE-R scores and subscores (memory, fluency, and language) in MSA patients.

Conclusions

Decreased FA values in the anterior corpus callosum showed a significant correlation with cognitive impairment in MSA.

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Title: Corpus callosal involvement is correlated with cognitive impairment in multiple system atrophy
Authors: Kazuhiro Hara
Hirohisa Watanabe
Epifanio Bagarinao
Kazuya Kawabata
Noritaka Yoneyama
Reiko Ohdake
Kazunori Imai
Michihito Masuda
Takamasa Yokoi
Aya Ogura
Takashi Tsuboi
Mizuki Ito
Naoki Atsuta
Hisayoshi Niwa
Toshiaki Taoka
Satoshi Maesawa
Shinji Naganawa
Masahisa Katsuno
Gen Sobue
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 9/2018
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-018-8923-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Corpus callosal involvement is correlated with cognitive impairment in multiple system atrophy

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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