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Journal of Neurology
Published in: Journal of Neurology 1/2019

Open Access 01-01-2019 | Review

Neuroimaging in Lewy body dementia

Authors: Tayyabah Yousaf, George Dervenoulas, Polytimi-Eleni Valkimadi, Marios Politis

Published in: Journal of Neurology | Issue 1/2019

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Abstract

Lewy body dementia (DLB) is a common form of cognitive impairment, accounting for 30% of dementia cases in ages over 65 years. Early diagnosis of DLB has been challenging; particularly in the context of differentiation with Parkinson’s disease dementia and other forms of dementias, such as Alzheimer’s disease and rapidly progressive dementias. Current practice involves the use of [123I]FP-CIT-SPECT, [18F]FDG PET and [123I]MIBG molecular imaging to support diagnostic procedures. Structural imaging techniques have an essential role for excluding structural causes, which could lead to a DLB-like phenotype, as well as aiding differential diagnosis through illustrating disease-specific patterns of atrophy. Novel PET molecular imaging modalities, such as amyloid and tau imaging, may provide further insights into DLB pathophysiology and may aid in early diagnosis. A multimodal approach, through combining various established techniques and possibly using novel radioligands, might further aid towards an in-depth understanding of this highly disabling disease. In this review, we will provide an overview of neuroimaging applications in patients with DLB.
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Metadata
Title
Neuroimaging in Lewy body dementia
Authors
Tayyabah Yousaf
George Dervenoulas
Polytimi-Eleni Valkimadi
Marios Politis
Publication date
01-01-2019
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 1/2019
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-018-8892-x

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