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01-12-2018 | Review

Dilemma of multiple system atrophy and spinocerebellar ataxias

Authors: Ming Li, Qianqian Ma, Xing Zhao, Can Wang, Huijie Wu, Jinyao Li, Wei Yang

Published in: Journal of Neurology | Issue 12/2018

Abstract

Multiple system atrophy (MSA) and spinocerebellar ataxias (SCAs) are both progressive neurodegenerative disorders, which can manifest cerebellar dysfunctions and parkinsonism-related symptoms, although the former is sporadic and the latter is autosomal dominant disease. Routinely, diagnosis is primarily based on clinical information—thorough history and physical examination should be included. Provided family history obtained, distinguishing SCAs from MSA is easy. However, how can we diagnose MSA or SCAs, in case of insufficient and unconvinced clinical symptoms or family history? Especially, familial MSA cases had been reported recently. We may drop into a dilemma resulting from analogous manifestations between MSA and SCAs. Herein, we aim to give a comprehensive introduction of MSA and SCAs, mainly in phenotype and genotype, and then address the connection and difference between them. Recently, some studies had been put forward to figure out the overlapped features between MSA and SCAs. Through this review, we want to discuss the possibility of misdiagnosis between MSA and SCAs.

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Title: Dilemma of multiple system atrophy and spinocerebellar ataxias
Authors: Ming Li
Qianqian Ma
Xing Zhao
Can Wang
Huijie Wu
Jinyao Li
Wei Yang
Publication date: 01-12-2018
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 12/2018
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-018-8876-x

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Dilemma of multiple system atrophy and spinocerebellar ataxias

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Other articles of this Issue 12/2018

Serum irisin is upregulated in patients affected by amyotrophic lateral sclerosis and correlates with functional and metabolic status

Nerve sheath tumours

Effect of mechanical thrombectomy alone or in combination with intravenous thrombolysis for acute ischemic stroke

Cerebral small vessel disease burden and functional and radiographic outcomes in intracerebral hemorrhage

Mixed TDP-43 proteinopathy and tauopathy in frontotemporal lobar degeneration: nine case series

Acute antiepileptic drug use in intensive care units